Výsledky vyhledávání - "Hilda M. Jafarah"

Abstract B024: Using CRISPR-Cas9 to understand the role of SNAI2 in malignant peripheral nerve sheath tumors (MPNST) cell lines

Autor: Hilda M. Jafarah, Xiyuan Zhang, Bega Murray, Jack Shern

Publikováno v: Cancer Research. 82:B024-B024

Background: MPNST are highly aggressive soft tissue sarcomas. Various recurrent genetic mutations have been linked to the malignant transformation from neoplastic Schwann cells to MPNST, including the loss of SUZ12 and/or EED, which are core componen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8922dac466d7149116dea58a0c07d6a9
https://doi.org/10.1158/1538-7445.cancepi22-b024

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Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

Autor: Xiyuan Zhang, Hannah E. Lou, Vishaka Gopalan, Zhihui Liu, Hilda M. Jafarah, Haiyan Lei, Paige Jones, Carly M. Sayers, Marielle E. Yohe, Prashant Chittiboina, Brigitte C. Widemann, Carol J. Thiele, Michael C. Kelly, Sridhar Hannenhalli, Jack F. Shern

Publikováno v: Cell Reports. 40:111363

Loss-of-function mutations in the polycomb repressive complex 2 (PRC2) occur frequently in malignant peripheral nerve sheath tumor, an aggressive sarcoma that arises from NF1-deficient Schwann cells. To define the oncogenic mechanisms underlying PRC2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1351074c631e3b9614f7a1b3c17cd0
https://doi.org/10.1016/j.celrep.2022.111363

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