Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Hilary Wynne"'
Publikováno v:
British Journal of Haematology. 195:790-801
It is unclear whether elderly patients established on direct oral anticoagulants (DOACs) have greater exposure to these drugs, which could subsequently increase their risk of bleeding. We assessed DOAC exposure and factors affecting it in a real-worl
Publikováno v:
Journal of Thrombosis and Thrombolysis
Patients on warfarin are required to withdraw from treatment for a fixed period (normally 5 days) prior to an invasive procedure. However, the anticoagulant effect of warfarin subsides at different rates among different patients, exposing some to inc
Publikováno v:
Thrombosis Research. 171:167-170
Warfarin therapy is stopped for a fixed period prior to surgery to minimise risk of perioperative bleeding. However, anticoagulation subsides at varying rates among different patients. We evaluated the influence of genetic (CYP2C9 and VKORC1), patien
Autor:
Hilary Wynne, Lisa Jones, Louise Green, Peter Avery, Bradley Dickinson, Campbell Tait, Joanna Nightingale, Salah Abohelaika, Julie Salisbury, Farhad Kamali, Brian Robinson
Publikováno v:
European Journal of Haematology. 101:486-495
Objectives: Time within therapeutic INR range (TTR) predicts benefits/risk of warfarin therapy. Identification of individual- and centre-related factors that influence TTR, and addressing them to improve anticoagulation control, are important. This s
Autor:
Kate Talks, Peter Avery, Tina Biss, Farhad Kamali, John Hanley, Hilary Wynne, Emmanouela Kampouraki
Publikováno v:
British Journal of Haematology. 178:800-809
Summary Current guidelines advocate using fixed-doses of oral vitamin K to reverse excessive anticoagulation in warfarinised patients who are either asymptomatic or have minor bleeds. Over-anticoagulated patients present with a wide range of Internat
Autor:
Emmanouela Kampouraki, Salah Abohelaika, Peter Avery, Tina Biss, Paul Murphy, Hilary Wynne, Farhad Kamali
Publikováno v:
SSRN Electronic Journal.
Publikováno v:
British Journal of Clinical Pharmacology. 82:1076-1083
Aims Stabilization of anticoagulation control is seminal to reducing the risk of adverse effects of vitamin K antagonists. Reliable information on how ageing influences this is lacking. We set out to assess the true age-related changes in anticoagula
Publikováno v:
International Journal of Clinical Pharmacology & Toxicology. :192-194
Autor:
Salah, Abohelaika, Hilary, Wynne, Peter, Avery, Brian, Robinson, Patrick, Kesteven, Farhad, Kamali
Publikováno v:
British journal of clinical pharmacology. 82(4)
Stabilization of anticoagulation control is seminal to reducing the risk of adverse effects of vitamin K antagonists. Reliable information on how ageing influences this is lacking. We set out to assess the true age-related changes in anticoagulation
Autor:
Hilary Wynne, Farhad Kamali
Publikováno v:
Annual Review of Medicine. 61:63-75
Warfarin is a drug with a narrow therapeutic index and a wide interindividual variability in dose requirement. Because it is difficult to predict an accurate dose for an individual, patients starting the drug are at risk of thromboembolism or bleedin