Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Hilary Szabo"'
Autor:
JOHN Malona, CLAUDIO CHUAQUI, BORIS M. SELETSKY, LISA BEEBE, SUSAN CANTIN, DANIEL VAN KALKEN, KELLY FAHNOE, ZHIGANG WANG, BETH BROWNING, HILARY SZABO, LOUISE A. KOOPMAN, TAMAS ORAVECZ, JOSEPH J. MCDONALD, FRANCISCO RAMIREZ-VALLE, RAJULA GAUR, KOFI A. MENSAH, MICHAEL THOMAS, JAMIE N. CONNARN, HAIQING HU, MATTHEW D. ALEXANDER, ALAN F. CORIN
Publikováno v:
Translational research : the journal of laboratory and clinical medicine. 249
As an anti-inflammatory strategy, MAPK-activated protein kinase-2 (MK2) inhibition can potentially avoid the clinical failures seen for direct p38 inhibitors, especially tachyphylaxis. CC-99677, a selective targeted covalent MK2 inhibitor, employs a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6afca613da09ae7ab956e9811531b01
https://pubmed.ncbi.nlm.nih.gov/35691544
https://pubmed.ncbi.nlm.nih.gov/35691544
Autor:
Thomas W. Gero, John Thomas Feutrill, Bailing Chen, Nathanael S. Gray, Feru Frederic, Brian J. Groendyke, Hilary Szabo, Zhengnian Li, Bin Li, David A. Scott, Chelsea E. Powell
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(19)
The protein kinase TNK2 (ACK1) is an emerging drug target for a variety of indications, in particular for cancer where it plays a key role transmitting cell survival, growth and proliferative signals via modification of multiple downstream effectors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220bb5eba35eecf2c507de3c0f2c8533
https://pubmed.ncbi.nlm.nih.gov/32739400
https://pubmed.ncbi.nlm.nih.gov/32739400
Autor:
Brian J. Groendyke, John Thomas Feutrill, Thomas W. Gero, Zhengnian Li, David A. Scott, Feru Frederic, Chelsea E. Powell, Hilary Szabo, Kevin Pang, Bailing Chen, Bin Li, Nathanael S. Gray
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(4)
The SAR of a series of benzopyrimidodiazepinone inhibitors of TNK2 was developed, starting from the potent and selective compound XMD8-87. A diverse set of anilines was introduced in an effort to improve the in vivo PK profile and minimize the risk o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fad4c04cad6c1f0bdde67bcc8337e5
https://pubmed.ncbi.nlm.nih.gov/31928839
https://pubmed.ncbi.nlm.nih.gov/31928839