Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Hilary P. Browne"'
Autor:
Samuel C. Forster, Junyan Liu, Nitin Kumar, Emily L. Gulliver, Jodee A. Gould, Alejandra Escobar-Zepeda, Tapoka Mkandawire, Lindsay J. Pike, Yan Shao, Mark D. Stares, Hilary P. Browne, B. Anne Neville, Trevor D. Lawley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Here, Forster et al. compare 1354 cultured commensal strains (540 species) to 45,403 pathogen strains (12 species), identifying 64,188 MGE-mediated antibiotic resistance gene transfer events between the two groups, and show that 15 broad host range M
Externí odkaz:
https://doaj.org/article/6b3f3a14687c4d9ea992587fbf554cd6
Host adaptation in gut Firmicutes is associated with sporulation loss and altered transmission cycle
Autor:
Hilary P. Browne, Alexandre Almeida, Nitin Kumar, Kevin Vervier, Anne T. Adoum, Elisa Viciani, Nicholas J. R. Dawson, Samuel C. Forster, Claire Cormie, David Goulding, Trevor D. Lawley
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-20 (2021)
Abstract Background Human-to-human transmission of symbiotic, anaerobic bacteria is a fundamental evolutionary adaptation essential for membership of the human gut microbiota. However, despite its importance, the genomic and biological adaptations un
Externí odkaz:
https://doaj.org/article/921bbadd3ff24b9e8f397afe36e63df8
Autor:
Caroline Mullineaux-Sanders, Danielle Carson, Eve G. D. Hopkins, Izabela Glegola-Madejska, Alejandra Escobar-Zepeda, Hilary P. Browne, Trevor D. Lawley, Gad Frankel
Publikováno v:
mBio, Vol 12, Iss 5 (2021)
Gut bacterial infections involve three-way interactions between virulence factors, the host immune responses, and the microbiome. While the microbiome erects colonization resistance barriers, pathogens employ virulence factors to overcome them.
Externí odkaz:
https://doaj.org/article/26b6e62002a94344be6faf9d79c3a812
Publikováno v:
Current opinion in microbiology. 69
Humans are colonised by a highly adapted microbiota with coevolved functions that promote human health, development and disease resistance. Acquisition and assembly of the microbiota start at birth and recent evidence suggests that it coincides with,
Autor:
Benjamin S. Beresford-Jones, Samuel C. Forster, Mark D. Stares, George Notley, Elisa Viciani, Hilary P. Browne, Daniel J. Boehmler, Amelia T. Soderholm, Nitin Kumar, Kevin Vervier, Justin R. Cross, Alexandre Almeida, Trevor D. Lawley, Virginia A. Pedicord
Publikováno v:
Cell Host & Microbe
Summary Human health and disease have increasingly been shown to be impacted by the gut microbiota, and mouse models are essential for investigating these effects. However, the compositions of human and mouse gut microbiotas are distinct, limiting tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b788fd70c50baa6c4e252ed917bbba16
Autor:
Ana Zhu, Tim Raine, Christopher J. Kiely, Anne T. Adoum, Mark D. Stares, Juan De La Revilla Negro, Nina Powell, Nitin Kumar, Stephen E. Moss, Trevor D. Lawley, Kevin Vervier, Meg Barne, Miles Parkes, Arthur Kaser, B. Anne Neville, Hilary P. Browne
ObjectiveReducing FODMAPs can be clinically beneficial in IBS but the mechanism is poorly understood. We aimed to detect microbial signatures that might predict response to the low FODMAP diet and assess whether microbiota compositional and functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01add13d95d7daf29558ec45b15f1520
https://www.repository.cam.ac.uk/handle/1810/330040
https://www.repository.cam.ac.uk/handle/1810/330040
Autor:
Samuel C, Forster, Junyan, Liu, Nitin, Kumar, Emily L, Gulliver, Jodee A, Gould, Alejandra, Escobar-Zepeda, Tapoka, Mkandawire, Lindsay J, Pike, Yan, Shao, Mark D, Stares, Hilary P, Browne, B Anne, Neville, Trevor D, Lawley
Publikováno v:
Nature communications. 13(1)
Mobile genetic elements (MGEs) carrying antibiotic resistance genes (ARGs) disseminate ARGs when they mobilise into new bacterial hosts. The nature of such horizontal gene transfer (HGT) events between human gut commensals and pathogens remain poorly
Autor:
Izabela Glegola-Madejska, Gad Frankel, Caroline Mullineaux-Sanders, Alejandra Escobar-Zepeda, Trevor D. Lawley, Eve G D Hopkins, Hilary P. Browne, Danielle Carson
Publikováno v:
mBio
mBio, Vol 12, Iss 5 (2021)
mBio, Vol 12, Iss 5 (2021)
The gut microbiota plays a crucial role in susceptibility to enteric pathogens, including Citrobacter rodentium, a model extracellular mouse pathogen that colonizes the colonic mucosa. C. rodentium infection outcomes vary between mouse strains, with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44d31ca709a92977a96741c3a22a547
http://hdl.handle.net/10044/1/91671
http://hdl.handle.net/10044/1/91671
Host adaptation in gut Firmicutes is associated with sporulation loss and altered transmission cycle
Autor:
Nicholas J. R. Dawson, Claire Cormie, Trevor D. Lawley, David Goulding, Alexandre Almeida, Nitin Kumar, Elisa Viciani, Hilary P. Browne, Kevin Vervier, Samuel C. Forster, Anne T. Adoum
Publikováno v:
Genome Biology
Genome Biology, Vol 22, Iss 1, Pp 1-20 (2021)
Genome Biology, Vol 22, Iss 1, Pp 1-20 (2021)
Background Human-to-human transmission of symbiotic, anaerobic bacteria is a fundamental evolutionary adaptation essential for membership of the human gut microbiota. However, despite its importance, the genomic and biological adaptations underpinnin
Autor:
Trevor D. Lawley, Ana Zhu, Thomas J. Louie, Mark D. Stares, Yan Shao, Matthew Dunn, Alex L. Mitchell, B. Anne Neville, Hilary P. Browne, Elisa Viciani, Lindsay J. Pike, Samuel C. Forster, Nitin Kumar, Blessing O. Anonye, Tapoka T. Mkandawire, Alexandre Almeida, Robert D. Finn
Publikováno v:
Nature Biotechnology
Understanding gut microbiome functions requires cultivated bacteria for experimental validation and reference bacterial genome sequences to interpret metagenome datasets and guide functional analyses. We present the Human Gastrointestinal Bacteria Cu