Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Hilary Knowles"'
Publikováno v:
Biochemical Society transactions. 50(6)
The interplay of signalling input and downstream transcriptional activity is the key molecular attribute driving the differentiation of germ layer tissue and the specification of cell lineages within each germ layer during gastrulation. This review d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f55c6cc1be0013b60cfc4c9a1e75ac
https://pubmed.ncbi.nlm.nih.gov/36398790
https://pubmed.ncbi.nlm.nih.gov/36398790
Autor:
Hilary Knowles, Nicole Santucci, Joshua Studdert, Hwee Ngee Goh, Keren Kaufman‐Francis, Nazmus Salehin, Patrick P. L. Tam, Pierre Osteil
Publikováno v:
genesis. 60
Allocation of cells to an endodermal fate in the gastrulating embryo is driven by Nodal signaling and consequent activation of TGFβ pathway. In vitro methodologies striving to recapitulate the process of endoderm differentiation, however, use TGFβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d4e4e8f9d8616918b838fb1f1de9a7
https://doi.org/10.1002/dvg.23466
https://doi.org/10.1002/dvg.23466
Autor:
Tennille, Sibbritt, Pierre, Osteil, Xiaochen, Fan, Jane, Sun, Nazmus, Salehin, Hilary, Knowles, Joanne, Shen, Patrick P L, Tam
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1940
Efficient and reliable methods for gene editing are critical for the generation of loss-of-gene function stem cells and genetically modified mice. Here, we outline the application of CRISPR-Cas9 technology for gene editing in mouse embryonic stem cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d021c008e1bf5d41be93d9cd9954bea7
https://pubmed.ncbi.nlm.nih.gov/30788819
https://pubmed.ncbi.nlm.nih.gov/30788819
Autor:
Jing-Dong J. Han, Patrick P.L. Tam, Guangdun Peng, Joshua B. Studdert, Naihe Jing, Hwee Ngee Goh, Nazmus Salehin, Hilary Knowles, Xiaochen Fan, Nicolas Fossat, Emilie E. Wilkie, Poh-Lynn Khoo, Pierre Osteil
Publikováno v:
Development.
During embryogenesis, a stringent regulation of Wnt activity is critical for the morphogenesis of the head and brain. The loss of function of the Wnt inhibitor, Dkk1, results in elevated Wnt activity, loss of ectoderm lineage attributes from the ante
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fb3f08f608bb0e4e9a5073e3a8ec60
https://doi.org/10.1242/dev.172858
https://doi.org/10.1242/dev.172858