Cell-controlled dynamic surfaces for skeletal stem cell growth and differentiation

Autor: Hilary J. Anderson, Jugal Kishore Sahoo, Julia Wells, Sebastiaan van Nuffel, Hala S. Dhowre, Richard O. C. Oreffo, Mischa Zelzer, Rein V. Ulijn, Matthew J. Dalby

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract Skeletal stem cells (SSCs, or mesenchymal stromal cells typically referred to as mesenchymal stem cells from the bone marrow) are a dynamic progenitor population that can enter quiescence, self-renew or differentiate depending on regenerativ

Externí odkaz: https://doaj.org/article/880f57ea76234d0e9bd8f308f8dbfe2f

Nitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosis.

Autor: Karen K Y Lam, Xingji Zheng, Roberto Forestieri, Aruna D Balgi, Matt Nodwell, Sarah Vollett, Hilary J Anderson, Raymond J Andersen, Yossef Av-Gay, Michel Roberge

Publikováno v: PLoS Pathogens, Vol 8, Iss 5, p e1002691 (2012)

Tuberculosis, caused by Mycobacterium tuberculosis infection, is a major cause of morbidity and mortality in the world today. M. tuberculosis hijacks the phagosome-lysosome trafficking pathway to escape clearance from infected macrophages. There is i

Externí odkaz: https://doaj.org/article/b5b29aa927074b68b0fa10d67f939761

The Autophagy Inhibitor Verteporfin Moderately Enhances the Antitumor Activity of Gemcitabine in a Pancreatic Ductal Adenocarcinoma Model

Autor: Natalia Zisman, Marcel B. Bally, Magali Zeisser-Labouebe, Sylvia S. W. Ng, Hilary J. Anderson, Murray S. Webb, Anitha Thomas, Norbert Maurer, Michel Roberge, Irina Manisali, Elizabeth Donohue

Publikováno v: Journal of Cancer

Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to chemotherapy. It has been described as requiring elevated autophagy for growth and inhibiting autophagy has been proposed as a treatment strategy. To date, all preclinical reports and cli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e420429eaad9e07b9f61d6cc5b3e31a2
https://doi.org/10.7150/jca.7030

Novel small molecules potentiate premature termination codon readthrough by aminoglycosides

Autor: Fahimeh S. Shidmoossavee, Yoko Shimizu, James Brian Jaquith, Vincent Mouly, Kunho Choi, Jason Samuel Tan, Michel Roberge, Célia Bergeaud, Alireza Baradaran-Heravi, Eric Jan, Aruna D. Balgi, Hilary J. Anderson, Stephane Flibotte, Tom A. Pfeifer, Carla Zimmerman, Alexandra Krause

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2016, 44 (14), pp.6583-6598. ⟨10.1093/nar/gkw638⟩
Nucleic Acids Research, 2016, 44 (14), pp.6583-6598. ⟨10.1093/nar/gkw638⟩

International audience; Nonsense mutations introduce premature termination codons and underlie 11% of genetic disease cases. High concentrations of aminoglycosides can restore gene function by eliciting premature termination codon readthrough but wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e816c31735baee6faeb421c95de21bf
https://hal.sorbonne-universite.fr/hal-01375660/document

Phosphorylation-induced Rearrangement of the Histone H3 NH2-terminal Domain during Mitotic Chromosome Condensation

Autor: Michel Roberge, Jill M. Ray, Debra M. Sauvé, Hilary J. Anderson, William M. James

Publikováno v: The Journal of Cell Biology

The NH2-terminal domain (N-tail) of histone H3 has been implicated in chromatin compaction and its phosphorylation at Ser10 is tightly correlated with mitotic chromosome condensation. We have developed one mAb that specifically recognizes histone H3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27a1fd67ae5d73fa9820d0132027bffe
http://europepmc.org/articles/PMC2133119