Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Hilary J, Lewis"'
Autor:
Thomas G. Hayhow, Beth Williamson, Mandy Lawson, Natalie Cureton, Erin L. Braybrooke, Andrew Campbell, Rodrigo J. Carbajo, Azadeh Cheraghchi-Bashi, Elisabetta Chiarparin, Coura R. Diène, Charlene Fallan, David I. Fisher, Frederick W. Goldberg, Lorna Hopcroft, Philip Hopcroft, Anne Jackson, Jason G. Kettle, Teresa Klinowska, Ulrike Künzel, Gillian Lamont, Hilary J. Lewis, Gareth Maglennon, Scott Martin, Pablo Morentin Gutierrez, Christopher J. Morrow, Myria Nikolaou, J. Willem M. Nissink, Patrick O’Shea, Radoslaw Polanski, Markus Schade, James S. Scott, Aaron Smith, Judith Weber, Joanne Wilson, Bin Yang, Claire Crafter
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-17 (2024)
Abstract Targeting the estrogen receptor alpha (ERα) pathway is validated in the clinic as an effective means to treat ER+ breast cancers. Here we present the development of a VHL-targeting and orally bioavailable proteolysis-targeting chimera (PROT
Externí odkaz:
https://doaj.org/article/ec006f9560824ea494be6041bb1eeb60
Autor:
Vasudev Kantae, Radoslaw Polanski, Hilary J. Lewis, Afreen Haider, Derek Barratt, Bharath Srinivasan
Publikováno v:
ACS Chemical Biology. 17:2366-2376
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07efb16c53ebabc031572d6ee971f369
https://doi.org/10.1021/acschembio.2c00483
https://doi.org/10.1021/acschembio.2c00483
Autor:
Jason G. Kettle, Sharan K. Bagal, Sue Bickerton, Michael S. Bodnarchuk, Scott Boyd, Jason Breed, Rodrigo J. Carbajo, Doyle J. Cassar, Atanu Chakraborty, Sabina Cosulich, Iain Cumming, Michael Davies, Nichola L. Davies, Andrew Eatherton, Laura Evans, Lyman Feron, Shaun Fillery, Emma S. Gleave, Frederick W. Goldberg, Lyndsey Hanson, Stephanie Harlfinger, Martin Howard, Rachel Howells, Anne Jackson, Paul Kemmitt, Gillian Lamont, Scott Lamont, Hilary J. Lewis, Libin Liu, Michael J. Niedbala, Christopher Phillips, Radek Polanski, Piotr Raubo, Graeme Robb, David M. Robinson, Sarah Ross, Matthew G. Sanders, Michael Tonge, Rebecca Whiteley, Stephen Wilkinson, Junsheng Yang, Wenman Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:6940-6952
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cb2a4d859543d18252213a2d5a9b54c
https://doi.org/10.1021/acs.jmedchem.2c00369
https://doi.org/10.1021/acs.jmedchem.2c00369
Autor:
Michael J. Deery, Marianne Schimpl, Derek Barratt, Hilary J. Lewis, Morgan Thomas, David Robinson, Deepa Bhavsar, Michael S. Bodnarchuk, Kirsten McAulay, Michael J. Waring, Derek Ogg, Emily A. Hoyt, Richard A. Ward, Gonçalo J. L. Bernardes, Jason Grant Kettle
Publikováno v:
Journal of the American Chemical Society. 142:10358-10372
With a resurgence in interest in covalent drugs, there is a need to identify new moieties capable of cysteine bond formation that are differentiated from commonly employed systems such as acrylamide. Herein, we report on the discovery of new alkynyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698b7b9835c15e18abf6592ff62a81ee
https://doi.org/10.1021/jacs.9b13391
https://doi.org/10.1021/jacs.9b13391
Autor:
Rodrigo J. Carbajo, S. Harlfinger, Lyman Feron, Jason Grant Kettle, E.S. Gleave, Hilary J. Lewis, L. Liu, A. Jackson, Doyle Joseph Cassar, Sharanjeet Kaur Bagal, David Robinson, Radoslaw Polanski, L. Zhang, M.R. Howard, Sabina Cosulich, L. Evans, Jason Breed, Graeme R. Robb, A. Chakraborty, Rachel L. Howells, Rebecca Whiteley, Scott G. Lamont, Lyndsey Hanson, J.K. Kingston, Michael Davies, Iain A. Cumming, Sarah Ross, Sue Bickerton, Paul D. Kemmitt, Derek Ogg, Andrew John Eatherton, James M. Smith, S. Li, Bodnarchuk, Frederick W. Goldberg, Christopher R. Phillips, X. Zhao, Jun Yang, Michael Tonge, Shaun M. Fillery
Publikováno v:
Journal of Medicinal Chemistry. 63:4468-4483
Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRASG12C mutant represents an "Achilles heel" and has recently yielded to covalent targeting with small mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c0d1227f159830cde7d87c48972047a
https://doi.org/10.1021/acs.jmedchem.9b01720
https://doi.org/10.1021/acs.jmedchem.9b01720
Autor:
Christopher J. Rhodes, James Conway, Jacqueline Naylor, James L. Trevaskis, Martin R. Larsen, Michael Feigh, Stephanie Oldham, Karly M. Mather, Rhianna C. Laker, Arkadiusz Nawrocki, Owen P. McGuinness, Michelle L. Boland, Louise Lantier, Hilary J. Lewis, Cristina M. Rondinone, Sanne Skovgård Veidal, Joseph Grimsby, Brandon B. Boland, Silvia Guionaud, Lutz Jermutus
Publikováno v:
Nature metabolism
Boland, M L, Laker, R C, Mather, K, Nawrocki, A, Oldham, S, Boland, B B, Lewis, H, Conway, J, Naylor, J, Guionaud, S, Feigh, M, Veidal, S S, Lantier, L, McGuinness, O P, Grimsby, J, Rondinone, C M, Jermutus, L, Larsen, M R, Trevaskis, J L & Rhodes, C J 2020, ' Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis ', Nature Metabolism, vol. 2, pp. 413-431 . https://doi.org/10.1038/s42255-020-0209-6
Boland, M L, Laker, R C, Mather, K, Nawrocki, A, Oldham, S, Boland, B B, Lewis, H, Conway, J, Naylor, J, Guionaud, S, Feigh, M, Veidal, S S, Lantier, L, McGuinness, O P, Grimsby, J, Rondinone, C M, Jermutus, L, Larsen, M R, Trevaskis, J L & Rhodes, C J 2020, ' Resolution of NASH and hepatic fibrosis by the GLP-1R and GCGR dual-agonist cotadutide via modulating mitochondrial function and lipogenesis ', Nature Metabolism, vol. 2, pp. 413-431 . https://doi.org/10.1038/s42255-020-0209-6
Non-alcoholic fatty liver disease and steatohepatitis are highly associated with obesity and type 2 diabetes mellitus. Cotadutide, a glucagon-like protein-1 receptor (GLP-1R) and glucagon receptor (GCGR) agonist, was shown to reduce blood glycaemia,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a154b21d10a7a6084ce4ee3d908d2b20
https://pubmed.ncbi.nlm.nih.gov/32478287
https://pubmed.ncbi.nlm.nih.gov/32478287
Autor:
Jason G, Kettle, Sharan K, Bagal, Sue, Bickerton, Michael S, Bodnarchuk, Jason, Breed, Rodrigo J, Carbajo, Doyle J, Cassar, Atanu, Chakraborty, Sabina, Cosulich, Iain, Cumming, Michael, Davies, Andrew, Eatherton, Laura, Evans, Lyman, Feron, Shaun, Fillery, Emma S, Gleave, Frederick W, Goldberg, Stephanie, Harlfinger, Lyndsey, Hanson, Martin, Howard, Rachel, Howells, Anne, Jackson, Paul, Kemmitt, Jennifer K, Kingston, Scott, Lamont, Hilary J, Lewis, Songlei, Li, Libin, Liu, Derek, Ogg, Christopher, Phillips, Radek, Polanski, Graeme, Robb, David, Robinson, Sarah, Ross, James M, Smith, Michael, Tonge, Rebecca, Whiteley, Junsheng, Yang, Longfei, Zhang, Xiliang, Zhao
Publikováno v:
Journal of medicinal chemistry. 63(9)
Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRAS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::26cfa402e109914535c92b373ce688b5
https://pubmed.ncbi.nlm.nih.gov/32023060
https://pubmed.ncbi.nlm.nih.gov/32023060
Autor:
Giulia Fabbri, Jordi Bertran-Alamillo, David Britton, Shona Ellison, Jon Travers, Urszula M. Polanska, Ana Giménez-Capitán, Vinothini Rajeeve, Jelena Urosevic, Pedro Rodriguez-Cutillas, Arran Dokal, Miguel Angel Molina-Vila, Maruan Higazi-Vega, Edmund Wilkes, J. Elizabeth Pease, Ruth Osuntola, Calum Greenhalgh, Hilary J. Lewis
Publikováno v:
Cancer Research. 81:1107-1107
Background: NSCLC cells carrying EGFR mutations can gain resistance to cognate TKIs through amplification of Chr22q11.2 (Chr22amp), a chromosome segment containing CRKL. This also specifically associates with exquisite sensitivity to inhibitors of Au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77e7edbbc584daa218d7b72ca1f5ce17
https://doi.org/10.1158/1538-7445.am2021-1107
https://doi.org/10.1158/1538-7445.am2021-1107
Autor:
Christophe Kerninon, Robin J.M. Franklin, Charles ffrench-Constant, Chao Zhao, Alerie Guzman de la Fuente, Hilary J. Lewis, Andrew A. Jarjour, Oihana Errea, Peter van Wijngaarden, Jeffrey K. Huang, Clare A. Jones, Ginez A. Gonzalez, Brahim Nait-Oumesmar
Publikováno v:
The Journal of Cell Biology
Activation of retinoid X receptor γ and vitamin D receptor (VDR) heterodimer via vitamin D enhances oligodendrocyte progenitor differentiation, whereas blocking VDR impairs differentiation and myelination ex vivo.
The mechanisms regulating diff
The mechanisms regulating diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a25016f9892e44ec1c88d8208d740e8
https://doi.org/10.1083/jcb.201505119
https://doi.org/10.1083/jcb.201505119
Publikováno v:
Molecular Microbiology. 84:1062-1078
Summary The purple phototrophic bacteria elaborate a specialized intracytoplasmic membrane (ICM) system for the conversion of solar energy to ATP. Previous radiolabelling and ultrastructural experiments have shown that ICM assembly in Rhodobacter sph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::683adc292ef6f29acc680a6dde60d88e
https://doi.org/10.1111/j.1365-2958.2012.08074.x
https://doi.org/10.1111/j.1365-2958.2012.08074.x