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Analysis of companion cell and phloem metabolism using a transcriptome-guided model of Arabidopsis metabolism

Autor: Hilary Hunt, Nico Brueggen, Alexander Galle, Sandy Vanderauwera, Claus Frohberg, Alisdair R Fernie, Uwe Sonnewald, Lee J Sweetlove

Publikováno v: Plant Physiology. 192:1359-1377

Companion cells and sieve elements play an essential role in vascular plants, and yet the details of the metabolism that underpins their function remain largely unknown. Here, we construct a tissue-scale flux balance analysis (FBA) model to describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04543fd2deda1c2ec72af81f7605a7fd
https://doi.org/10.1093/plphys/kiad154

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IP3R activity increases propensity of RyR-mediated sparks by elevating dyadic [Ca2＋]

Autor: Joshua Chung, Agnė Tilūnaitė, David Ladd, Hilary Hunt, Christian Soeller, Edmund J. Crampin, Stuart T. Johnston, H. Llewelyn Roderick, Vijay Rajagopal

Calcium (Ca2＋) plays a critical role in the excitation contraction coupling (ECC) process that mediates the contraction of cardiomyocytes during each heartbeat. While ryanodine receptors (RyRs) are the primary Ca2＋ channels responsible for genera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532ed78c0038c68efd2beb0c44d7007a

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Ca2+ Release via IP3 Receptors Shapes the Cardiac Ca2+ Transient for Hypertrophic Signaling

Autor: H. Llewelyn Roderick, Greg Bass, Vijay Rajagopal, Agnė Tilūnaitė, Hilary Hunt, Christian Soeller, Edmund J. Crampin

Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signaling in ventricular cardiomyocytes. L-type Ca2+ channels trigger release of Ca2+ from ryanodine receptors for cellular contraction, whereas signaling dow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809ad806f7f0a6dcaaf502f1de8bcb73
https://lirias.kuleuven.be/handle/123456789/663610

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IP3R activity increases frequency of RyR-mediated sparks by elevating dyadic Ca2+

Autor: Joshua Chung, Agnė Tilūnaitė, David Ladd, Hilary Hunt, Christian Soeller, Edmund J. Crampin, Stuart Johnston, H. Llewelyn Roderick, Vijay Rajagopal

Calcium plays critical roles in cardiac cells, coupling electrical excitation to mechanical contraction with each heartbeat, while simultaneously mediating biochemical signals that regulate cell growth. While ryanodine receptors (RyRs) are fundamenta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5e07e4e3cffd2997022b50405ad3c895
https://doi.org/10.1101/2020.08.13.249144

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Autor: Hilary, Hunt, Agnė, Tilūnaitė, Greg, Bass, Christian, Soeller, H Llewelyn, Roderick, Vijay, Rajagopal, Edmund J, Crampin

Publikováno v: Biophys J

Calcium (Ca(2+)) plays a central role in mediating both contractile function and hypertrophic signaling in ventricular cardiomyocytes. L-type Ca(2+) channels trigger release of Ca(2+) from ryanodine receptors for cellular contraction, whereas signali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e4c02c17a11c572b0afde16672018adf
https://pubmed.ncbi.nlm.nih.gov/32871099

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Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

Autor: Cameron G. Walker, Shouryadipta Ghosh, Vijay Rajagopal, Eric Hanssen, Gregory T. Bass, Hilary Hunt, Edmund J. Crampin, Christian Soeller

With the advent of three-dimensional (3D) imaging technologies such as electron tomography, serial-block-face scanning electron microscopy and confocal microscopy, the scientific community has unprecedented access to large datasets at sub-micrometer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fa86c1d68b3616c0fa2036edffe2a83
https://europepmc.org/articles/PMC6100652/

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Phonics is a good way to sound off

Autor: Hilary Hunt

Publikováno v: Five to Seven. 2:ii-iv

IF CHILDREN are given a knowledge of phonics, they will be better equipped to deal with ‘difficult’ words they meet in books of all kinds in their school life, and indeed in adulthood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4560fb2a2d9290468b2cedf43c052e1
https://doi.org/10.12968/ftoe.2002.2.2.16675

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