Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hilary Hii"'
Autor:
Jacqueline P. Whitehouse, Hilary Hii, Chelsea Mayoh, Marie Wong, Pamela Ajuyah, Paulette Barahona, Louise Cui, Hetal Dholaria, Christine L. White, Molly K. Buntine, Jacob Byrne, Keteryne Rodrigues da Silva, Meegan Howlett, Emily J. Girard, Maria Tsoli, David S. Ziegler, Jason M. Dyke, Sharon Lee, Paul G. Ekert, Mark J. Cowley, Nicholas G. Gottardo, Raelene Endersby
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionEpendymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged 0-14
Externí odkaz:
https://doaj.org/article/009c2573d20c46b8a58d763a746781a4
Autor:
Jessica Buck, Patrick J. C. Dyer, Hilary Hii, Brooke Carline, Mani Kuchibhotla, Jacob Byrne, Meegan Howlett, Jacqueline Whitehouse, Martin A. Ebert, Kerrie L. McDonald, Nicholas G. Gottardo, Raelene Endersby
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the inductio
Externí odkaz:
https://doaj.org/article/84c2daf88f7a475d8429aa6028e5b6ae
Autor:
Raelene Endersby, Jacqueline Whitehouse, Hilary Hii, Sameer A. Greenall, Terrance G. Johns, Nicholas G. Gottardo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 5, Pp 432-442 (2018)
Glioblastoma in adults, and medulloblastoma and pineoblastoma that mainly affect children, are aggressive brain tumors. The survival for patients with glioblastoma remains dismal. While the cure rate for medulloblastoma exceeds 70%, this figure has s
Externí odkaz:
https://doaj.org/article/7f5070b369af47c19f46c70ea06d4549
Autor:
Sasha Rogers, Hilary Hii, Joel Huang, Mathew Ancliffe, Nick G Gottardo, Peter Dallas, Sharon Lee, Raelene Endersby
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175169 (2017)
Biopsy is often used to investigate brain tumour-specific abnormalities so that treatments can be appropriately tailored. Dacomitinib (PF-00299804) is a tyrosine kinase inhibitor (TKI), which is predicted to only be effective in cancers where the tar
Externí odkaz:
https://doaj.org/article/0fda144d36e244dc91601b2620cc56ea
Autor:
Jacqueline Whitehouse, Meegan Howlett, Jessica Buck, Kale Somers, Jessica Lawler, Hilary Hii, Brooke Carline, Mani Kuchibhotla, Bhedita Sewoo, Tim Rosenow, Kirk Feindel, Martin Ebert, Andrew Mehnert, Nicholas Gottardo, Raelene Endersby
Publikováno v:
Neuro-Oncology. 24:i177-i178
Pediatric brain cancer patients treated with fractionated radiotherapy commonly develop long-term late side-effects including cognitive deficits. Many preclinical models of late effects have been developed that use a single, high dose of radiotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::852bc7bda20e2aa76f7bb2fd1016ea20
https://doi.org/10.1093/neuonc/noac079.661
https://doi.org/10.1093/neuonc/noac079.661
Autor:
Zahra Abbas, Jessica Buck, Mathew Ancliffe, Clara Andradas Arias, Meegan Howlett, Hilary Hii, Terrance Johns, Siddhartha Mitra, Nicholas Gottardo, Raelene Endersby
Publikováno v:
Neuro-Oncology. 24:i172-i173
Medulloblastoma is the most common paediatric brain cancer. Standard treatment approaches, including craniospinal irradiation (CSI), can result in severe lifelong side effects and have not changed for decades resulting in a stagnation of survival out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14c2eccee208ea29c066affa178f57b8
https://doi.org/10.1093/neuonc/noac079.641
https://doi.org/10.1093/neuonc/noac079.641
Autor:
Hetal Dholaria, Jessica Buck, Hilary Hii, Brooke Carline, Jacob Bryne, Mani Kuchibhotla, Jessica Lawler, Gilbert Porter, Jacqueline Whitehouse, Meegan Howlett, Nick Gottardo, Raelene Endersby
Publikováno v:
Neuro-Oncology. 24:i173-i173
Despite treatment intensification, survival for certain high-risk subgroups of medulloblastoma (MB) such as p53 mutant SHH (SHHa) and MYC amplified Group 3 (Gr3) have remained dismal. Recently, the use of Carboplatin as radiosensitiser with craniospi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffae744bab99e3a65b077f80bb45cbe9
https://doi.org/10.1093/neuonc/noac079.642
https://doi.org/10.1093/neuonc/noac079.642
Autor:
Raelene Endersby, Jacqueline Whitehouse, Martin A. Ebert, Hilary Hii, Patrick Dyer, Jacob Byrne, Jessica Buck, Mani Kuchibhotla, Meegan Howlett, Brooke Carline, Kerrie L. McDonald, Nicholas G. Gottardo
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences, Vol 8 (2021)
Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the inductio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be66c4bd624f98548a4bf6574486ba3
https://doi.org/10.3389/fmolb.2021.633344
https://doi.org/10.3389/fmolb.2021.633344
Autor:
Mathew Ancliffe, Courtney George, Clara Andradas, Clinton F. Stewart, Martine F. Roussel, Jacqueline Whitehouse, Robert J. Wechsler-Reya, Mark E. Cooper, Raelene Endersby, Brooke Carline, Amar Gajjar, Allison Pribnow, Silvia K. Tacheva-Gigorova, Giles W. Robinson, Marcel Kool, Jennifer L. Stripay, Nicholas G. Gottardo, Suresh Gande, Brett Patterson, Stefan M. Pfister, Marjolein Schluck, Terrance Grant Johns, Patrick Dyer, Till Milde, Mani Kuchibhotla, Hilary Hii, Meegan Howlett, Tobias Schoep
Publikováno v:
Sci Transl Med
Science Translational Medicine, 13
Science Translational Medicine, 13, 577
Science Translational Medicine, 13
Science Translational Medicine, 13, 577
Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd7b78a59841c08d1bc3de806945dd1
https://europepmc.org/articles/PMC8994821/
https://europepmc.org/articles/PMC8994821/
Autor:
Raelene Endersby, Pamela Ajuyah, Jason Stanley, Clara Andradas, Nicholas G. Gottardo, Sharon Lee, Santosh Valvi, Brooke Carline, Marie Wong, Mark J. Cowley, Jason M Dyke, Paul G Ekert, Christine L. White, Paulette Barahona, Jacqueline Whitehouse, Meegan Howlett, Chelsea Mayoh, Hilary Hii, Molly Buntine, Mani Kuchibhotla
Publikováno v:
Cancers, Vol 12, Iss 2937, p 2937 (2020)
Cancers
Volume 12
Issue 10
Cancers
Volume 12
Issue 10
Simple Summary Radiation-induced glioma (RIG) is a highly aggressive brain cancer arising as a consequence of radiation therapy, for which there is currently no effective treatment. In order to test new drugs in the hope of finding more effective the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c530159694a4482d1662fbe1c809945
https://www.mdpi.com/2072-6694/12/10/2937
https://www.mdpi.com/2072-6694/12/10/2937