Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Hilary E Keiser"'
Autor:
Robert Lipski, Daniel J Lippincott, Brittany C Durden, Anne R Kaplan, Hilary E Keiser, Jung-Ho Park, Aime A Levesque
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42615 (2012)
DNA damage induced by the topoisomerase I inhibitor SN38 activates cell cycle checkpoints which promote cell cycle arrest. This arrest can be abrogated in p53-defective cells by the Chk1 inhibitor 7-hydroxystaurosporine (UCN-01). Previously, we compa
Externí odkaz:
https://doaj.org/article/9bb815b69d5f4ab8b85027c93c2a69c0
Autor:
Robert Lipski, Jung-Ho Park, Aime A. Levesque, Anne R. Kaplan, Hilary E. Keiser, Brittany C. Durden, Daniel J. Lippincott
Publikováno v:
Cancer Research. 72:2220-2220
DNA damage activates cell cycle checkpoints to promote cell cycle arrest. p53 is a major player in checkpoints by activating expression of the cdk inhibitor p21 and repressing expression of cyclin B. DNA damage-induced S and G2 arrest following treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::678b637294e81a5b38685785b2056701
https://doi.org/10.1158/1538-7445.am2012-2220
https://doi.org/10.1158/1538-7445.am2012-2220