Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Hilary B Whitlatch"'
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Akademický článek
Randomized evaluation of the loss‐of‐function carboxylesterase 1 (CES1) G143E variant on clopidogrel and ticagrelor pharmacodynamics
Autor: Joshua P. Lewis, Kathleen A. Ryan, Elizabeth A. Streeten, Hilary B. Whitlatch, Melanie Daue, Keith Tanner, James A. Perry, Jeffrey R. O'Connell, Alan R. Shuldiner, Braxton D. Mitchell
Publikováno v: Clinical and Translational Science, Vol 17, Iss 11, Pp n/a-n/a (2024)
Abstract Antiplatelet therapy with a P2Y12 receptor inhibitor, in combination with aspirin, is standard of care for medical management of patients with coronary artery disease, and flexibility in prescribing options among these medications offers gre
Externí odkaz: https://doaj.org/article/f0d43cfe0e25404a84926e644c4cd53b
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2
Akademický článek
Acute pharmacodynamic responses to sitagliptin: Drug‐induced increase in early insulin secretion in oral glucose tolerance test
Autor: Amber L. Beitelshees, Elizabeth A. Streeten, Zhinous Shahidzadeh Yazdi, Hilary B. Whitlatch, Braxton D. Mitchell, Alan R. Shuldiner, May E. Montasser, Simeon I. Taylor
Publikováno v: Clinical and Translational Science, Vol 17, Iss 5, Pp n/a-n/a (2024)
Abstract DPP4 inhibitors are widely prescribed as treatments for type 2 diabetes. Because drug responses vary among individuals, we initiated investigations to identify genetic variants associated with the magnitude of drug responses. Sitagliptin (10
Externí odkaz: https://doaj.org/article/b3cad01e7001482bb125303fa5d0bad4
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4
Vitamin D deficiency increases vulnerability to canagliflozin-induced adverse effects on 1,25-dihydroxyvitamin D and PTH
Autor: Zhinous Shahidzadeh Yazdi, Elizabeth A. Streeten, Hilary B. Whitlatch, May E. Montasser, Amber L. Beitelshees, Simeon I. Taylor
ContextCanagliflozin has been reported to increase the risk of bone fracture – possibly mediated by decreasing 1,25-dihydroxyvitamin D [1,25(OH)2D] and increasing PTH.ObjectiveTo investigate whether baseline vitamin D (VitD) deficiency renders indi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b15e2eb38bc7f3c2cdc3da2b1eb4d8e5
https://doi.org/10.1101/2023.05.11.23289854
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5
Pharmacogenetics of SGLT2 Inhibitors: Validation of a sex-agnostic pharmacodynamic biomarker
Autor: Simeon I. Taylor, Hua-Ren Cherng, Zhinous Shahidzadeh Yazdi, May E. Montasser, Hilary B. Whitlatch, Braxton D. Mitchell, Alan R. Shuldiner, Elizabeth A. Streeten, Amber L. Beitelshees
Publikováno v: medRxiv
BackgroundSGLT2 inhibitors provide multiple benefits to patients with type 2 diabetes – including improved glycemic control and decreased risks of cardiorenal disease. Because drug responses vary among individuals, we initiated investigations to id
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37de4f2f3b80e0b759c43bbdab89f85
https://doi.org/10.1101/2023.03.07.23286875
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8
PSUN253 Cocaine Use Resulting in Inadvertent Sulfonylurea Overdose
Autor: Chikara Gothong, Hilary B Whitlatch
Publikováno v: Journal of the Endocrine Society. 6:A392-A393
Introduction Most street cocaine is cut with other substances to increase drug volume. Often, cutting agents are used that change or intensify the effects of the drug. We present a case in which sulfonylurea-laced cocaine resulted in life-threatening
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6960f4c9929ed88ec117285a9261c93d
https://doi.org/10.1210/jendso/bvac150.817
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