Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Hilary A. Wilkinson"'
Autor:
Cristina Sampaio, Hilary A. Wilkinson
Publikováno v:
EBioMedicine, Vol 94, Iss , Pp 104710- (2023)
Externí odkaz:
https://doaj.org/article/12d50a90fe294090b827a93719b57743
Autor:
Natsuko Macabuag, William Esmieu, Perla Breccia, Rebecca Jarvis, Wesley Blackaby, Ovadia Lazari, Liudvikas Urbonas, Maria Eznarriaga, Rachel Williams, Annelieke Strijbosch, Rhea Van de Bospoort, Kim Matthews, Cole Clissold, Tammy Ladduwahetty, Huw Vater, Patrick Heaphy, Douglas G. Stafford, Hong-Jun Wang, John E. Mangette, George McAllister, Vahri Beaumont, Thomas F. Vogt, Hilary A. Wilkinson, Elizabeth M. Doherty, Celia Dominguez
Publikováno v:
Journal of medicinal chemistry. 65(18)
Huntington's disease (HD) is a lethal autosomal dominant neurodegenerative disorder resulting from a CAG repeat expansion in the huntingtin (
Autor:
Jung-Hoon Lee, Maren Thomsen, Herwin Daub, Stefan C. Steinbacher, Agnieszka Sztyler, Gabriel Thieulin-Pardo, Tobias Neudegger, Nikolay V. Plotnikov, Ravi R. Iyer, Hilary A. Wilkinson, Edith Monteagudo, Dan P. Felsenfeld, Tasir S. Haque, Michael Finley, Celia Dominguez, Thomas F. Vogt, Brinda C. Prasad
Huntington’s disease (HD) is fatal neurodegenerative disorder caused by the expansion of a CAG-repeat tract in the huntingtin (HTT) gene. Human and mouse genetics studies have demonstrated a role for DNA mismatch repair (MMR) proteins which control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::183b5ff9f85869d81d144088519fcbbf
https://doi.org/10.1101/2023.05.08.539930
https://doi.org/10.1101/2023.05.08.539930
Supplementary Data from Estrogen-related receptor-α antagonist inhibits both estrogen receptor–positive and estrogen receptor–negative breast tumor growth in mouse xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23713c69bb8f6ce03db111a76be2e540
https://doi.org/10.1158/1535-7163.22484927
https://doi.org/10.1158/1535-7163.22484927
Estrogen-related receptors (ERR) are orphan members of the nuclear receptor superfamily most closely related to estrogen receptors (ER). Although ERα is a successful target for treating breast cancer, there remains an unmet medical need especially f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00153ec0baacb68c1003cc7d76f61eb
https://doi.org/10.1158/1535-7163.c.6531659
https://doi.org/10.1158/1535-7163.c.6531659
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5624 (2009)
The orphan nuclear receptor estrogen-related receptor alpha (ERRalpha) is a member of the nuclear receptor superfamily. It was identified through a search for genes encoding proteins related to estrogen receptor alpha (ERalpha). An endogenous ligand
Externí odkaz:
https://doaj.org/article/ed8a3f51a2924496a2d2725845007fee
Autor:
Azriel Schmidt, Michael Chisamore, Carlo J. Gambone, Gregory Michael Dillon, Stephen E. Alves, Matthew Baran, Sean Riley, Michael A. Gentile, Osvaldo A. Flores, Hilary A. Wilkinson
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 163:88-97
The androgen receptor (AR) is a member of the nuclear hormone receptor super family of transcription factors. Androgens play an essential role in the development, growth, and maintenance of male sex organs, as well as the musculoskeletal and central
Autor:
Changyou Zhou, David Sutton, Hong Li, Shaoqiang Huang, Xianghong Huo, Hilary A. Wilkinson, Haisheng Wang, Lusong Luo, Dennis M. Zaller, Hank Wang, Gui-Bai Liang, Wei Tang, Peter T. Meinke, Xuelin Yang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4077-4080
In a search for novel small molecule calcium-sensing receptor (CaSR) antagonists as oral bone anabolic agents, we discovered dihydrobenzofuran cyclopropane carboxylic acid derivatives, such as 12f (IC50=27.6nM), are highly potent calcium-sensing rece
Autor:
William J. Ray, Chang Bai, Stephen E. Alves, Tara E. Cusick, Brenda L Pennypacker, Evan E. Opas, Michael J. Chisamore, Carlo J. Gambone, Damien Ferraro, David J. Bettoun, Azriel Schmidt, Hilary A. Wilkinson, Angela Scafonas, Michael A. Gentile, Osvaldo A. Flores, Paul Hodor, Meissner Robert S, James J. Perkins
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 143:29-39
Prostate cancer (PCa) initially responds to inhibition of androgen receptor (AR) signaling, but inevitably progresses to hormone ablation-resistant disease. Much effort is focused on optimizing this androgen deprivation strategy by improving hormone
Autor:
Janet Clegg, Hilary Browne Wilkinson
A must-have guide book for anyone is a relationship or about to begin one. Packed full of wide-ranging scenarios and case studies, Happily Ever After…? explores the pitfalls and issues which often lead to marriage breakups and explains how to succe