Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Hilary Mackay"'
Autor:
Megan Lee, Amanda Ferguson, Shuo Wang, Balaji Babu, W. David Wilson, John A. Hartley, Toni Rice, Robert Sjoholm, Moses Lee, Hilary Mackay, Konstantinos Kiakos, Pravin C. Patil, Shicai Lin, Samuel Tzou, Joseph P. Ramos, Adam J. Plaunt, Sameer Chavda
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:3907-3918
Orthogonally positioned diamino/dicationic polyamides (PAs) have good water solubility and enhanced binding affinity, whilst retaining DNA minor groove and sequence specificity compared to their monoamino/monocationic counterparts. The synthesis and
Autor:
Toni Rice, Samuel Tzou, Mary Pressler, Robert Sjoholm, Moses Lee, Ross Ogilvie, Hilary Mackay, Adam J. Plaunt, Michael D Seymour, Vijay Satam, Olivia Sweat, Hao Shen, Shannon Alger, Balaji Babu, Kimberly A. Brien
Publikováno v:
hc. 18:79-85
Covalently linked pyrrole (Py)- and imidazole (Im)-containing H-pin polyamides bind in the minor groove of specific DNA sequences with high affinity. The synthesis of 1,2,3-triazole-linked and heterodimeric H-pin polyamides 13a,b formed from the Huis
Autor:
R.R. Davis, Jennifer Ruprich, Christopher Tronrud, John A. Hartley, Konstantinos Kiakos, Toni Rice, Hilary Mackay, Sharjeel A Tahir, Laura M. Westrate, Balaji Babu, Jerome Kluza, Chrystal D. Bruce, Andrew T. Franks, Chandler Adkins, Sameer Chavda, W. David Wilson, Moses Lee, Alan Sielaff, Yang Liu, Shicai Lin, Amanda Ferguson, Samuel Tzou
Publikováno v:
Biochemistry. 50:3127-3136
With the aim of incorporating a recognition element that acts as a fluorescent probe upon binding to DNA, three novel pyrrole (P) and imidazole (I)-containing polyamides were synthesized. The compounds contain a p-anisylbenzimidazolecarboxamido (Hx)
Autor:
Amanda Ferguson, Shicai Lin, Hilary Mackay, David Wilson, Toni Rice, Adam J. Plaunt, R.R. Davis, Konstantinos Kiakos, Laura M. Westrate, Moses Lee, Balaji Babu, Camille Riddering, Yang Liu, John A. Hartley, Ross Ogilvie, Sameer Chavda
Publikováno v:
Biochemical and Biophysical Research Communications. 404:848-852
An orthogonally positioned diamino/dicationic polyamide f-IPI 2 was synthesized. It has enhanced binding affinity, and it showed comparable sequence specificity to its monoamino/monocationic counterpart f-IPI 1. Results from CD and DNase I footprinti
Autor:
Balaji Babu, Susan L. Mooberry, Sameer Chavda, R.R. Davis, Moses Lee, Erin L. O’Brien, Lauren Lee, Lyda M. Robb, Megan Lee, April L. Risinger, Hilary Mackay
Publikováno v:
Journal of Medicinal Chemistry. 53:325-334
A total of 24 novel 2,5-diaryl-1,3,4-oxadiazoline analogs of combretastatin A-4 (CA-4, 1) were designed, synthesized, and evaluated for biological activities. The compounds represent two structural classes; the Type I class has three methoxy groups o
Autor:
Bijay K. Mishra, R.R. Davis, Amanda Ferguson, Adam M. Siegfried, Moses Lee, Camille Riddering, Hilary Mackay, Susan L. Mooberry, Hari N. Pati, Sameer Chavda, Miriam Shadfan, Balaji Babu, Kristin Dittenhafer, William T. Pennington
Publikováno v:
Letters in Drug Design & Discovery. 6:531-537
Autor:
W. David Wilson, Peter B. Uthe, Justin B. Jones, Alan Sielaff, Moses Lee, Caroline O'Hare, Laura M. Westrate, Jerome Kluza, James P. Lajiness, Binh Nguyen, Toni Brown, Zach Davis, Hilary Mackay, Chrystal D. Bruce, John A. Hartley
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:9145-9153
Imidazole (Im) and Pyrrole (Py)-containing polyamides that can form stacked dimers can be programmed to target specific sequences in the minor groove of DNA and control gene expression. Even though various designs of polyamides have been thoroughly i
Publikováno v:
Biochemical and Biophysical Research Communications. 369:630-634
Studies on the binding of a triamide f-IPI ( 1 ) to its cognate sequence labeled with a 2-aminopurine (2AP or G ∗ ) group are described. ITC studies showed that f-IPI ( 1 ) bound to the cognate site (ACG ∗ CGT) with only 3.5-fold lower affinity t
Autor:
Caroline O'Hare, Hilary Mackay, John A. Hartley, Toni Brown, Jerome Kluza, Binh Nguyen, Boris Savic, Jim S. Sexton, Daniel Hochhauser, W. David Wilson, Moses Lee, Minal Kotecha
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:2093-2102
The synthesis and DNA binding characteristics of a polyamide-intercalator conjugate, designed to inhibit NF-Y binding to the ICB-2 site of the topoisomerase IIalpha promoter and up-regulate the expression of the enzyme in confluent cells, are reporte
Autor:
Hilary Mackay, Peter B. Uthe, John A Hartley, Toni Brown, Moses Lee, W. David Wilson, Justin B. Jones, Caroline O'Hare, Binh Nguyen, Kevin N. Blackmon
Publikováno v:
Biochemistry. 46:11661-11670
The polyamide N-formamido imidazole-pyrrole-imidazole (f-ImPyIm) binds with an exceptionally high affinity for its cognate site 5'-ACGCGT-3' as a stacked, staggered, and noncovalent cooperative dimer. Investigations are presented into its sequence sp