Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Hilal Kazan"'
Autor:
Adelaida Kolaj, Siraj K. Zahr, Beatrix S. Wang, Taylor Krawec, Hilal Kazan, Guang Yang, David R. Kaplan, Freda D. Miller
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112242- (2023)
Summary: Here, we ask how developing precursors maintain the balance between cell genesis for tissue growth and establishment of adult stem cell pools, focusing on postnatal forebrain neural precursor cells (NPCs). We show that these NPCs are transcr
Externí odkaz:
https://doaj.org/article/f7de2f910d1f4882bd97afbe9a72baf7
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-16 (2021)
Abstract Background Recent cancer genomic studies have generated detailed molecular data on a large number of cancer patients. A key remaining problem in cancer genomics is the identification of driver genes. Results We propose BetweenNet, a computat
Externí odkaz:
https://doaj.org/article/b19b7e103c444db8bb2f876ff5a2b573
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-18 (2021)
Abstract Background Matrix factorization methods are linear models, with limited capability to model complex relations. In our work, we use tropical semiring to introduce non-linearity into matrix factorization models. We propose a method called Spar
Externí odkaz:
https://doaj.org/article/f15765827bf643e290ead08be2cf948d
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract The majority of the previous methods for identifying cancer driver modules output nonoverlapping modules. This assumption is biologically inaccurate as genes can participate in multiple molecular pathways. This is particularly true for cance
Externí odkaz:
https://doaj.org/article/5bdc5c1867664b96acee24c58817f5d4
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
One of the key concepts employed in cancer driver gene identification is that of mutual exclusivity (ME); a driver mutation is less likely to occur in case of an earlier mutation that has common functionality in the same molecular pathway. Several ME
Externí odkaz:
https://doaj.org/article/046a0e2c37cf42c0bb9be1cbdfc8ec12
Publikováno v:
Biology Direct, Vol 13, Iss 1, Pp 1-14 (2018)
Abstract Background Neuroblastoma is a heterogeneous disease with diverse clinical outcomes. Current risk group models require improvement as patients within the same risk group can still show variable prognosis. Recently collected genome-wide datase
Externí odkaz:
https://doaj.org/article/f9079cb394464f9185e460d940a3df43
Autor:
Sriram Chandrasekaran, Melike Cokol‐Cakmak, Nil Sahin, Kaan Yilancioglu, Hilal Kazan, James J Collins, Murat Cokol
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 5, Pp 1-12 (2016)
Abstract Combination antibiotic therapies are being increasingly used in the clinic to enhance potency and counter drug resistance. However, the large search space of candidate drugs and dosage regimes makes the identification of effective combinatio
Externí odkaz:
https://doaj.org/article/17f3a9120bf541f581b79c26f0a3f9d4
Autor:
Ruben G. de Bruin, Lily Shiue, Jurriën Prins, Hetty C. de Boer, Anjana Singh, W. Samuel Fagg, Janine M. van Gils, Jacques M. G. J. Duijs, Sol Katzman, Adriaan O. Kraaijeveld, Stefan Böhringer, Wai Y. Leung, Szymon M. Kielbasa, John P. Donahue, Patrick H.J. van der Zande, Rick Sijbom, Carla M. A. van Alem, Ilze Bot, Cees van Kooten, J. Wouter Jukema, Hilde Van Esch, Ton J. Rabelink, Hilal Kazan, Erik A. L. Biessen, Manuel Ares Jr., Anton Jan van Zonneveld, Eric P. van der Veer
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-20 (2016)
Post-transcriptional control of RNA is important in health and disease. Here, the authors show that the RNA-binding protein Quaking guides pre-mRNA splicing and transcript abundance during monocyte to macrophage differentiation, and that Quaking depl
Externí odkaz:
https://doaj.org/article/e34ae01b9e3449c1bdf812e5f403f63e
Autor:
Atefeh Lafzi, Hilal Kazan
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155354 (2016)
RNA-binding proteins (RBPs) play key roles in post-transcriptional regulation of mRNAs. Dysregulations in RBP-mediated mechanisms have been found to be associated with many steps of cancer initiation and progression. Despite this, previous studies of
Externí odkaz:
https://doaj.org/article/74a00ef49e5d4b90bb52d9a0e4dfc6c3
Publikováno v:
PLoS Computational Biology, Vol 6, p e1000832 (2010)
Metazoan genomes encode hundreds of RNA-binding proteins (RBPs). These proteins regulate post-transcriptional gene expression and have critical roles in numerous cellular processes including mRNA splicing, export, stability and translation. Despite t
Externí odkaz:
https://doaj.org/article/091c0f3c1f494a96b88137775890852a