Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Hikmat Al-Hashimi"'
1
Akademický článek
Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti‐tumor efficacy
Autor: Yasmin Yu, Madhumita Bogdan, Muhammad Zaeem Noman, Santiago Parpal, Elisabetta Bartolini, Kris Van Moer, Simone Caroline Kleinendorst, Kristine Bilgrav Saether, Lionel Trésaugues, Camilla Silvander, Johan Lindström, Jodi Simeon, Mary Jane Timson, Hikmat Al‐Hashimi, Bryan D. Smith, Daniel L. Flynn, Andrey Alexeyenko, Jenny Viklund, Martin Andersson, Jessica Martinsson, Katja Pokrovskaja Tamm, Angelo De Milito, Bassam Janji
Publikováno v: Molecular Oncology, Vol 18, Iss 8, Pp 1904-1922 (2024)
An immunosuppressive tumor microenvironment promotes tumor growth and is one of the main factors limiting the response to cancer immunotherapy. We have previously reported that inhibition of vacuolar protein sorting 34 (VPS34), a crucial lipid kinase
Externí odkaz: https://doaj.org/article/9dddee620d924c2eb795ae4895e7f6b3
Zobrazit plný text záznamu
2
Akademický článek
Novel exc Genes Involved in Formation of the Tubular Excretory Canals of Caenorhabditis elegans
Autor: Hikmat Al-Hashimi, Travis Chiarelli, Erik A. Lundquist, Matthew Buechner
Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 5, Pp 1339-1353 (2019)
Regulation of luminal diameter is critical to the function of small single-celled tubes, of which the seamless tubular excretory canals of Caenorhabditis elegans provide a tractable genetic model. Mutations in several sets of genes exhibit the Exc ph
Externí odkaz: https://doaj.org/article/9c15a539cbaf47639e5f70669550c93e
Zobrazit plný text záznamu
3
Akademický článek
A Series of Tubes: The C. elegans Excretory Canal Cell as a Model for Tubule Development
Autor: Matthew Buechner, Zhe Yang, Hikmat Al-Hashimi
Publikováno v: Journal of Developmental Biology, Vol 8, Iss 3, p 17 (2020)
Formation and regulation of properly sized epithelial tubes is essential for multicellular life. The excretory canal cell of C. elegans provides a powerful model for investigating the integration of the cytoskeleton, intracellular transport, and orga
Externí odkaz: https://doaj.org/article/3858cc4af29b47018ce73cea8739e49a
Zobrazit plný text záznamu
5
Abstract 4872: DCC-3116, a first-in-class selective ULK1/2 inhibitor of autophagy, in combination with the KIT inhibitor ripretinib induces complete regressions in GIST preclinical models
Autor: Madhumita Bogdan, Mary J. Timson, Hikmat Al-Hashimi, Bryan D. Smith, Daniel L. Flynn
Publikováno v: Cancer Research. 83:4872-4872
Background: Cancer cells activate autophagy as an adaptive stress response (ASR) mechanism to therapies targeting the RTK/RAS/MAPK/PI3K pathways, limiting antitumor response. Autophagy is initiated through ULK1/2 kinases and is triggered by inhibitor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c8e970a73387ae450ffd6ba6ca7d728
https://doi.org/10.1158/1538-7445.am2023-4872
Zobrazit plný text záznamu
6
Novel exc Genes Involved in Formation of the Tubular Excretory Canals of Caenorhabditis elegans
Autor: Matthew Buechner, Erik A. Lundquist, Hikmat Al-Hashimi, Travis Chiarelli
Publikováno v: G3: Genes, Genomes, Genetics, Vol 9, Iss 5, Pp 1339-1353 (2019)
Regulation of luminal diameter is critical to the function of small single-celled tubes, of which the seamless tubular excretory canals of Caenorhabditis elegans provide a tractable genetic model. Mutations in several sets of genes exhibit the Exc ph
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caec4090b5c632d9f7f7d8499eb4d815
http://g3journal.org/lookup/doi/10.1534/g3.119.200626
Zobrazit plný text záznamu
7
Abstract 3600: DCC-3116, a first-in-class selective inhibitor of ULK1/2 kinases and autophagy, synergizes with the KRASG12C inhibitor sotorasib resulting in tumor regression in KRAS mutant NSCLC xenograft models
Autor: Martin McMahon, Madhumita Bogdan, Mary J. Timson, Hikmat Al-Hashimi, Phaedra Ghazi, Yu Zhan, Bryan D. Smith, Conan G. Kinsey, Daniel L. Flynn
Publikováno v: Cancer Research. 82:3600-3600
Mutationally-activated RAS oncoproteins are detected in approximately 19% of newly diagnosed human cancers and have been targets for drug discovery for over 40 years. Recently, the FDA approved sotorasib, a covalent inhibitor of KRASG12C, for the tre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e88168da9ce8a7ac67b9a4b2624c45ba
https://doi.org/10.1158/1538-7445.am2022-3600
Zobrazit plný text záznamu
8
Tubular Excretory Canal Structure Depends on Intermediate Filaments EXC-2 and IFA-4 in Caenorhabditis elegans
Autor: Erik A. Lundquist, Hikmat Al-Hashimi, Brian D. Ackley, Matthew Buechner, David H. Hall
Publikováno v: Genetics. 210:637-652
The excretory canals of Caenorhabditis elegans are a model for understanding the maintenance of apical morphology in narrow single-celled tubes. Light and electron microscopy shows that mutants in exc-2 start to form canals normally, but these swell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5696a5af746cc9cf56502c13e82ff88d
https://doi.org/10.1534/genetics.118.301078
Zobrazit plný text záznamu
9
Abstract P084: DCC-3116, a first-in-class selective inhibitor of ULK1/2 kinases and autophagy, synergizes with EGFR inhibitors osimertinib and afatinib in NSCLC preclinical models
Autor: Madhumita Bogdan, Mary J. Timson, Hikmat Al-Hashimi, Yu Zhan, Bryan D. Smith, Daniel L. Flynn
Publikováno v: Molecular Cancer Therapeutics. 20:P084-P084
Background: Activating mutations in EGFR have been reported in ~30% of patients with non-small cell lung cancer (NSCLC). Three generations of small molecule EGFR kinase inhibitors have been approved by the FDA to treat these patients, however, multip
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3610e4b6b0a7d12b93c45373bc603725
https://doi.org/10.1158/1535-7163.targ-21-p084
Zobrazit plný text záznamu
10
A Series of Tubes: The C. elegans Excretory Canal Cell as a Model for Tubule Development
Autor: Hikmat Al-Hashimi, Matthew Buechner, Zhe Yang
Publikováno v: Journal of Developmental Biology
Journal of Developmental Biology, Vol 8, Iss 17, p 17 (2020)
Formation and regulation of properly sized epithelial tubes is essential for multicellular life. The excretory canal cell of C. elegans provides a powerful model for investigating the integration of the cytoskeleton, intracellular transport, and orga
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0044dff6bd51005d410871cdac0d11f5
https://doi.org/10.3390/jdb8030017
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje