Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Hikaru Yabuuchi"'
Publikováno v:
Drug Metabolism and Disposition. 38:1505-1513
N -[6-[2-[(5-Bromo-2-pyrimidinyl)oxy]ethoxy]-5-(4-methylphenyl)-4-pyrimidinyl]-4-(2-hydroxy-1,1-dimethylethyl) benzenesulfonamide sodium salt (TA-0201) carboxylic acid form (TA-0201CA) is the primary and pharmacologically active metabolite of TA-0201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585a8e2ec93ac5a99c02a385f2116a08
https://doi.org/10.1124/dmd.110.033258
https://doi.org/10.1124/dmd.110.033258
Publikováno v:
YAKUGAKU ZASSHI. 130:755-761
Monovalent bile acids, such as taurine- and glycine-conjugated bile acids, are excreted into bile by bile salt export pumps (BSEP, ABCB11). Human BSEP (hBSEP) is physiologically important because it was identified as the gene responsible for the gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62301ae72fa0a6463110a7ac7884ba2
https://doi.org/10.1248/yakushi.130.755
https://doi.org/10.1248/yakushi.130.755
Publikováno v:
Drug Metabolism and Pharmacokinetics. 25:214-219
A novel fluorescent bile acid derivative, 4-N,N-dimethylaminosulfonyl-2,1,3-benzoxadiazole- conjugated bile acid was synthesized as a probe to develop a rapid screening method for function analysis of bile salt export pump (BSEP, ABCB 11). The transp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0339ffda86802ae1d295995ba1c99943
https://doi.org/10.2133/dmpk.25.214
https://doi.org/10.2133/dmpk.25.214
Publikováno v:
Analytical Sciences. 25:1155-1158
The high performance liquid chromatography-electrospray ionization-mass spectrometry method has been applied to the measurement of bile acid transport activities in membrane vesicles obtained from a human bile salt export pump expressing Sf9 cells. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32566457b3a27a11f68c2f32cda9a3b0
https://doi.org/10.2116/analsci.25.1155
https://doi.org/10.2116/analsci.25.1155
Publikováno v:
European Journal of Pharmaceutical Sciences. 35:326-334
The monkey is an important experimental model in the pharmacological evaluation of new drugs. We isolated monkey multidrug resistance-associated protein 2 (MRP2) cDNA to examine expression profiles among various tissues and measured ATPase activity t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc32d8e514cebdb99b46a4bdf3ba05a3
https://doi.org/10.1016/j.ejps.2008.08.001
https://doi.org/10.1016/j.ejps.2008.08.001
Autor:
Miyako Maeda, Masaaki Takemura, Ikumi Tamai, Masaki Oka, Rikiya Ohashi, Tanaka Kenji, Hikaru Yabuuchi
Publikováno v:
Biopharmaceutics & Drug Disposition. 29:441-448
The dog bile salt export pump (BSEP; ABCB11) was cloned and expressed in a Sf9 insect cell system. The deduced amino acid sequence encodes a 1325-amino-acid protein, which shows 89.4% and 80.2% homology with human BSEP and rat Bsep, respectively. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb3bdd8aaadf648a919ccb15b4cf56c
https://doi.org/10.1002/bdd.629
https://doi.org/10.1002/bdd.629
Autor:
Thomas J. Cook, Ikumi Tamai, Hikaru Yabuuchi, Katsumasa Otake, Tomoji Maeda, Hiroshi Suzuki, Makoto Haga, Ryunosuke Higashi
Publikováno v:
Journal of Pharmaceutical Sciences. 97:1821-1830
Intestinal membrane permeability is an important factor affecting the bioavailability of drugs. As a strategy to improve membrane permeability, membrane transporters are useful targets since essential nutrients are absorbed efficiently via specific t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5a08a772ecd84371fe66c7c6184e29
https://doi.org/10.1002/jps.21147
https://doi.org/10.1002/jps.21147
Autor:
Ikumi Tamai, Tomoji Maeda, Hikaru Yabuuchi, Daisuke Kobayashi, Shin Aizawa, Kenji Yoshida, Shigeki Sugiura, Toshimichi Nakamura
Publikováno v:
Pharmaceutical Research. 24:1628-1635
Recently, it was reported that OCTN1 transporter (SLC22A4) is associated with rheumatoid arthritis (RA) and Crohn's disease. Additionally, we reported that OCTN1 is expressed in hematopoietic cells, preferentially in erythroid cells. Accordingly, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::089d5f2c0360564d80e43908cce7d4f8
https://doi.org/10.1007/s11095-007-9290-8
https://doi.org/10.1007/s11095-007-9290-8
Autor:
Hirotoshi Okumura, Miki Nakajima, Tsuyoshi Yokoi, Toshihiko Ikeda, Yoshinori Soeno, Katsutoshi Yoshizato, Toshiro Sawada, Miki Katoh, Hikaru Yabuuchi, Chise Tateno
Publikováno v:
Toxicological Sciences. 97:533-538
The liver of a chimeric urokinase-type plasminogen activator (uPA)(+/+)/severe combined immunodeficient (SCID) mouse line recently established in Japan could be replaced by more than 80% with human hepatocytes. We previously reported that the chimeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e87df1648ef0d386a42a1c34df1720f
https://doi.org/10.1093/toxsci/kfm041
https://doi.org/10.1093/toxsci/kfm041
Publikováno v:
Biological and Pharmaceutical Bulletin. 30:739-744
The non-steroidal antiandrogen flutamide is widely used for treatment of prostatic cancer, but causes side effects, including cholestatic hepatitis and fulminant hepatitis. We investigated the pathogenesis of flutamide-induced cholestatic hepatitis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da628b75a6df4f5f201b81cb9fa1e31
https://doi.org/10.1248/bpb.30.739
https://doi.org/10.1248/bpb.30.739