Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hikaru Sugihara"'
Autor:
Kazunori Kadota, Hirofumi Takeuchi, Yuichi Tozuka, Hikaru Sugihara, Yuta Miyazaki, Akio Nishiura
Publikováno v:
Journal of Drug Delivery Science and Technology. 36:1-9
This study describes a supercritical CO 2 (scCO 2 ) system, which combines supercritical antisolvent (SAS) and rapid expansion from supercritical to aqueous solution (RESAS) processes, enabling the preparation of a poorly water-soluble drug (ONO-2921
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7d92a663e8552f5037334fe230dd4a2
https://doi.org/10.1016/j.jddst.2016.08.010
https://doi.org/10.1016/j.jddst.2016.08.010
Autor:
Lynne S. Taylor, Hikaru Sugihara
Publikováno v:
Molecular pharmaceutics. 15(4)
Salts of weakly basic active pharmaceutical ingredients are widely used to improve aqueous solubility and/or dissolution rate. However, these compounds are prone to precipitation due to the lower solubility of the un-ionized species at the higher pH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8230ebd1d667c9ddedac8b2bf030b5c2
https://pubmed.ncbi.nlm.nih.gov/29502424
https://pubmed.ncbi.nlm.nih.gov/29502424
Autor:
Hikaru, SUGIHARA, Hirofumi, TAKEUCHI
Publikováno v:
岐阜薬科大学紀要 = The annual proceedings of Gifu Pharmaceutical University. 63:1-10
難吸収性薬物であるプランルカスト水和物について、1 日1 回服用型の経口持続性製剤としての設計を目指して検討を行った。プランルカスト水和物は難溶解性、難膜透過性薬物であるこ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=jairo_______::1b5bd5418738118243b1be075dade8f3
http://id.nii.ac.jp/1076/00012959/
http://id.nii.ac.jp/1076/00012959/
Autor:
Alyson Connor, Yuji Matsui, Hikaru Sugihara, Akio Nishiura, Ian R. Wilding, Kazuya Abe, Hirofumi Takeuchi
Publikováno v:
European Journal of Pharmaceutical Sciences. 53:62-68
Pranlukast hydrate was demonstrated in a human site-of-absorption study to have extremely poor absorption properties in the lower gastrointestinal tract. The ratios of AUC0-24 in the distal small bowel and colon compared to stomach delivery were appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e312518bb6cb4f66365b734e9a2352ee
https://doi.org/10.1016/j.ejps.2013.11.018
https://doi.org/10.1016/j.ejps.2013.11.018
Autor:
Kazunori Kadota, Hikaru Sugihara, Hirofumi Takeuchi, Yuta Miyazaki, Akio Nishiura, Yuichi Tozuka
Context: Dry powder inhaler (DPI) formulations have been developed to deliver large amounts of drugs to the lungs. Objective: Fine particles of a poorly water-soluble drug, the model drug ONO-2921, were prepared by the emulsion solvent diffusion (ESD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb0c249e03ffbdd6dc427b3aaba0d82
Publikováno v:
Chemical and Pharmaceutical Bulletin. 60:1320-1323
The gastrointestinal transition of mucoadhesive drug carriers may be affected by food intake, since food changes the physiological conditions of the gastrointestinal tract, and the food content itself is a physical obstruction for the drug carriers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f369daa77819f455ec3d9e1d69e733d
https://doi.org/10.1248/cpb.c12-00469
https://doi.org/10.1248/cpb.c12-00469
Autor:
Hirofumi Takeuchi, Hikaru Sugihara
Publikováno v:
YAKUGAKU ZASSHI. 130:1135-1142
We have developed polymer-coated liposomes for effective and non-invasive delivery of peptide drugs. Polymer-coated liposomes, which are liposomal particles coated with functional polymers, were designed in order to have suitable functions required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce2561113a317c8630451dcf234bc8b
https://doi.org/10.1248/yakushi.130.1135
https://doi.org/10.1248/yakushi.130.1135
Publikováno v:
Journal of liposome research. 22(1)
The plasma profile of indomethacin (IMC) after oral administration of IMC-loaded submicronized chitosan-coated liposomes (ssCS-Lip) was evaluated to reveal the effectiveness of the mucoadhesive function for improving the absorption of this poorly abs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2072de2765198b0d49b14306fbba5e84
https://pubmed.ncbi.nlm.nih.gov/22329417
https://pubmed.ncbi.nlm.nih.gov/22329417
Autor:
Takayuki Maruyama, Takashi Nakamura, Yonghui Jin, Shinsei Fujimura, K Ito, Akio Nishiura, Junya Toguchida, Takanobu Otsuka, Hiroto Mitsui, Hikaru Sugihara, Moritoshi Furu, Toshiya Kanaji, Tomoki Aoyama
Publikováno v:
Arthritis Research & Therapy
[Introduction]Osteoarthritis (OA) is a common cause of disability in older adults. We have previously reported that an agonist for subtypes EP2 of the prostaglandin E2 receptor (an EP2 agonist) promotes the regeneration of chondral and osteochondral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff298d959e6623b1c30e33026b2a043d
http://hdl.handle.net/2433/159697
http://hdl.handle.net/2433/159697
Autor:
Hikaru Sugihara, Hirofumi Takeuchi
Publikováno v:
ChemInform. 42
We have developed polymer-coated liposomes for effective and non-invasive delivery of peptide drugs. Polymer-coated liposomes, which are liposomal particles coated with functional polymers, were designed in order to have suitable functions required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c82e4cfb2c88767db70593e81a72a16
https://doi.org/10.1002/chin.201104274
https://doi.org/10.1002/chin.201104274