Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Hikaru Nakazawa"'
Combinatorial optimization of the hybrid cellulase complex structure designed from modular libraries
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Cellulase selectively recognizes cellulose surfaces and cleaves their β-1,4-glycosidic bonds. Combining hydrolysis using cellulase and fermentation can produce alternative fuels and chemical products. However, anaerobic bacteria produce onl
Externí odkaz:
https://doaj.org/article/b0fa33bd64b140f38c2b3bf6f7af88c5
Autor:
Andrejs Tučs, Tomoyuki Ito, Yoichi Kurumida, Sakiya Kawada, Hikaru Nakazawa, Yutaka Saito, Mitsuo Umetsu, Koji Tsuda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-7 (2024)
Abstract In designing functional biological sequences with machine learning, the activity predictor tends to be inaccurate due to shortage of data. Top ranked sequences are thus unlikely to contain effective ones. This paper proposes to take predicti
Externí odkaz:
https://doaj.org/article/0d7e74484286481ca47596de9fb39a2c
Autor:
Tomoyuki Ito, Thuy Duong Nguyen, Yutaka Saito, Yoichi Kurumida, Hikaru Nakazawa, Sakiya Kawada, Hafumi Nishi, Koji Tsuda, Tomoshi Kameda, Mitsuo Umetsu
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTDespite the advances in surface-display systems for directed evolution, variants with high affinity are not always enriched due to undesirable biases that increase target-unrelated variants during biopanning. Here, our goal was to design a li
Externí odkaz:
https://doaj.org/article/006271d38f2946dbaf222d586d863779
Autor:
Yoichiro Ito, Misa Ishigami, Goro Terai, Yasuyuki Nakamura, Noriko Hashiba, Teruyuki Nishi, Hikaru Nakazawa, Tomohisa Hasunuma, Kiyoshi Asai, Mitsuo Umetsu, Jun Ishii, Akihiko Kondo
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
A high-throughput workflow involving a streamlined genome-wide screen improves protein production in the non-conventional yeast, Komagataella phaffii, following adaptive laboratory evolution.
Externí odkaz:
https://doaj.org/article/f8d6b4a76d204cf09f7a566450ea6f5c
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract A fusion protein comprising an antibody and a cationic peptide, such as arginine-9 (R9), is a candidate molecule for efficient and cell-specific delivery of siRNA into cells in order to reduce the side effects of nucleic acid drugs. However,
Externí odkaz:
https://doaj.org/article/a93f63012e644dfbadfe780137a79059
Autor:
Aruto Sugiyama, Mitsuo Umetsu, Hikaru Nakazawa, Teppei Niide, Tomoko Onodera, Katsuhiro Hosokawa, Shuhei Hattori, Ryutaro Asano, Izumi Kumagai
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Small bispecific antibodies that induce T-cell–mediated cytotoxicity have the potential to damage late-stage tumor masses to a clinically relevant degree, but their cytotoxicity is critically dependent on their structural and functional pr
Externí odkaz:
https://doaj.org/article/f18cb9ec074743a0b52efdd168550715
Autor:
Wijak Yospanya, Akari Matsumura, Yukihiro Imasato, Tomoyuki Itou, Yusuke Aoki, Hikaru Nakazawa, Takashi Matsui, Takeshi Yokoyama, Mihoko Ui, Mitsuo Umetsu, Satoru Nagatoishi, Kouhei Tsumoto, Yoshikazu Tanaka, Kazushi Kinbara
Publikováno v:
Bulletin of the Chemical Society of Japan; Sep2024, Vol. 97 Issue 9, p1-8, 8p
Autor:
Yutaka Tamaru, Shuji Nakanishi, Kenya Tanaka, Mitsuo Umetsu, Hikaru Nakazawa, Aruto Sugiyama, Tomoyuki Ito, Naofumi Shimokawa, Masahiro Takagi
Publikováno v:
Journal of Bioscience and Bioengineering.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0df1d375139d52a0961cb923329d89be
https://doi.org/10.1016/j.jbiosc.2023.03.012
https://doi.org/10.1016/j.jbiosc.2023.03.012
Autor:
Mitsuo Umetsu, Hafumi Nishi, Mayu Yoshida, Hikaru Nakazawa, Reito Fukazawa, Sakiya Kawada, Tomoyuki Ito, Tomoshi Kameda
Publikováno v:
Chemistry Letters. 50:1867-1871
Antibody mimetics are proteins smaller than antibodies that have antigen-binding properties. Here, we used a combination of informatic selection and experimental verification to identify from a pub...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1b742573a5e70ab7a37a55852f006f8
https://doi.org/10.1246/cl.210443
https://doi.org/10.1246/cl.210443
Publikováno v:
Protein & Peptide Letters. 27:557-566
Background: By recent advances in phage-display approaches, many oligopeptides exhibiting binding affinities for metal oxides have been identified. Indium tin oxide is one of the most widely used conductive oxides, because it has a large band gap of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353f1fca05f779829a314345ccba14ba
https://doi.org/10.2174/0929866526666191113151934
https://doi.org/10.2174/0929866526666191113151934