Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hikaru Mitori"'
Autor:
Hikaru Mitori1,2 hikaru.mitori@astellas.com, Takeshi Izawa2, Mitsuru Kuwamura2, Masahiro Matsumoto1, Jyoji Yamate2
Publikováno v:
Journal of Toxicologic Pathology. 2018, Vol. 31 Issue 4, p301-306. 6p.
Publikováno v:
Journal of Toxicologic Pathology
In neonatal rats, glutamate could induce retinal thinning depending on the development stage, and the severity peaked at treatment on postnatal day (PND) 8. To elucidate the molecular mechanism of retinal thinning induced by L-glutamate in neonatal r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2074e75ff010c5fa32ed83e512779146
http://europepmc.org/articles/PMC6206281
http://europepmc.org/articles/PMC6206281
Autor:
Akira Unami, Masatoshi Yuri, Daisuke Sasaki, Gi Wook Hwang, Kenjiro Tsubota, Masashi Hiramoto, Akira Naganuma, Akira Moriguchi, Hikaru Mitori
Publikováno v:
Fundamental Toxicological Sciences. 4:77-83
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537782db174d4d99ac77fdfdde4f873a
https://doi.org/10.2131/fts.4.77
https://doi.org/10.2131/fts.4.77
Autor:
Ikuko Nakamura, Kiyomitsu Katsumata, Hikaru Mitori, Shinobu Takeda, Satoru Matsumoto, Keisuke Ohsumi, Souichiro Akamatsu, Toru Nakai
Publikováno v:
Antimicrobial Agents and Chemotherapy. 63
Current therapies against invasive pulmonary aspergillosis (IPA) have a limited cure rate. Given that a delay in treatment initiation may be fatal, a new drug with rapid-onset and potent fungicidal activity is needed. The novel cyclic hexapeptide ASP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11a1aca61d68e937d4997e9925f308a6
https://doi.org/10.1128/aac.02689-18
https://doi.org/10.1128/aac.02689-18
Autor:
Masaki Abe, Keiko Tanaka-Amino, Hikaru Mitori, Megumi Eguchi, Yutaka Inoki, Yusuke Wada, Akira Imasato, Mitsuhiro Kondo, Hiroshi Kajiyama, Toshihide Mimura, Hiroshi Moritani, Yuichi Tomura
Publikováno v:
Experimental Biology and Medicine. 241:1865-1876
Urinary nephrin is a potential non-invasive biomarker of disease. To date, however, most studies of urinary nephrin have been conducted in animal models of diabetic nephropathy, and correlations between urinary nephrin-to-creatinine ratio and other p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcb4e9f45558fa83dcfa524c619221b
https://doi.org/10.1177/1535370216651937
https://doi.org/10.1177/1535370216651937
Publikováno v:
Journal of Toxicologic Pathology. 29:181-184
Accumulation of macrophages containing brown pigments in the lungs is a well-known spontaneous lesion found in cynomolgus monkey. However, its pathogenesis has not been clearly described. In our survey, brown pigment-laden macrophages were found in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a43f8f8700b4ae885d5e8a302d7378d4
https://doi.org/10.1293/tox.2015-0079
https://doi.org/10.1293/tox.2015-0079
Autor:
Shoji Takakura, Yuka Hayashizaki-Someya, Kumi Koide, Shunji Yamazaki, Toshiyuki Takasu, Hikaru Mitori, Eiji Kurosaki
Publikováno v:
European Journal of Pharmacology. 754:19-24
Ipragliflozin is a selective sodium glucose cotransporter 2 (SGLT2) inhibitor that increases urinary glucose excretion by inhibiting renal glucose reabsorption and thereby causes a subsequent antihyperglycemic effect. As nonalcoholic fatty liver dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ac67a5195ecfade9a07b3045dd322d
https://doi.org/10.1016/j.ejphar.2015.02.009
https://doi.org/10.1016/j.ejphar.2015.02.009
Publikováno v:
Toxicologic pathology. 44(8)
The neurotransmitter glutamate causes excitotoxicity in the human retina. In neonatal rats, the degree of glutamate-induced retinal damage depends on age at administration. To elucidate the sensitivity to glutamate on various developing stage of reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82ccc86513b90fde51e487c52e392e5
https://pubmed.ncbi.nlm.nih.gov/28245157
https://pubmed.ncbi.nlm.nih.gov/28245157
Publikováno v:
European Journal of Pharmacology. 737:106-116
While pirfenidone has been established as an effective anti-fibrosis remedy, whether or not its antifibrotic effect contributes to a reduction of proteinuria remains unclear. We investigated the renoprotective properties of pirfenidone in an anti-glo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a488eb9ac24c415bc0e231e2c31d61b
https://doi.org/10.1016/j.ejphar.2014.05.015
https://doi.org/10.1016/j.ejphar.2014.05.015
Autor:
Hikaru Mitori, Yoichi Miyamae, Akira Moriguchi, Atsushi Yamada, Akira Unami, Masayuki Kanki, Daisuke Sasaki
Publikováno v:
Toxicology. 324
Despite increased focus in recent years on urinary microRNA (miRNA) biomarkers in patients with diabetes and chronic kidney diseases, few studies have explored urinary miRNA markers in drug-induced nephrotoxicity. Here, we attempted to identify urina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35c26219964ed2535e9ffb9f4eec9c71
https://pubmed.ncbi.nlm.nih.gov/24863737
https://pubmed.ncbi.nlm.nih.gov/24863737