Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Hikaru Hashitani"'
Publikováno v:
Continence, Vol 10, Iss , Pp 101223- (2024)
The external urethral sphincter (EUS), composed of skeletal muscle, along with a smooth muscle-lined internal urethral sphincter (IUS), have crucial roles in maintaining continence during bladder filling and facilitating urine flow during voiding. Di
Externí odkaz:
https://doaj.org/article/0ac897f0276f460ba515539b3eec48fb
Publikováno v:
Pharmacology Research & Perspectives, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract The aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre‐contracted with 5‐HT (100 μM). Upon generation of
Externí odkaz:
https://doaj.org/article/1fba7bf45bc64cf8bf25111a1b61fb98
Autor:
Masaaki Kurahashi, Yoshihiko Kito, Masayasu Hara, Hiromitsu Takeyama, Kenton M. Sanders, Hikaru Hashitani
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 3, Pp 658-671.e1 (2020)
Background & Aims: Colonic musculature contain smooth muscle cells (SMC), interstitial cells of Cajal (ICC), and platelet-derived growth factor receptor α+ cells (PDGFRα+ cells), which are electrically coupled and operate together as the SIP syncyt
Externí odkaz:
https://doaj.org/article/af344ece5cec4ffd86f08150d0b5abde
Autor:
Takeshi Okinami, Masaaki Imamura, Nobuyuki Nishikawa, Hiromitsu Negoro, Yoshio Sugino, Koji Yoshimura, Akihiro Kanematsu, Hikaru Hashitani, Osamu Ogawa
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104216 (2014)
Lower urinary tract symptoms (LUTS) include storage, voiding and post-micturition symptoms, featuring many urological diseases. Storage symptoms are the most frequent among these and associated with overactive bladder and non-bacterial bladder inflam
Externí odkaz:
https://doaj.org/article/df33dc6b05934b85a456ddb23154bf1a
Autor:
Hiroyuki Nakamori, Hikaru Hashitani
In isolated segments of the rat proximal colon, the dopamine reuptake inhibitor GBR 12909 (GBR) causes dilatation, while the D1-like receptor antagonist SCH 23390 (SCH) causes a tonic constriction, suggesting that neurally-released dopamine tonically
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1803247b3dd4d2141198b3ab9d2cfff7
https://doi.org/10.21203/rs.3.rs-2356668/v1
https://doi.org/10.21203/rs.3.rs-2356668/v1
Autor:
Mitsue Takeya, Ryuhei Higashi, Hikaru Hashitani, Kei‐ichiro Nakamura, Tokumasa Hayashi, Noriyuki Nakashima, Makoto Takano
Publikováno v:
The Journal of Physiology. 600:1703-1730
Autor:
Masaaki Kurahashi, Salah A. Baker, Yoshihiko Kito, Allison Bartlett, Masayasu Hara, Hiromitsu Takeyama, Hikaru Hashitani, Kenton M. Sanders
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology. 14:357-373
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 473:1925-1938
Here we investigate mechanisms underlying spontaneous phasic contractions (SPCs) and sympathetic control of contractility in the rat epididymis, a long tubular duct involved in transportation and maturation of sperm. Longitudinal contractions of shor
Publikováno v:
Pflugers Archiv : European journal of physiology. 474(10)
Parathyroid hormone-related protein (PTHrP) released from detrusor smooth muscle (DSM) as the bladder fills acts as an endogenous DSM relaxant to facilitate bladder storage function. Here, the effects of exogenous PTHrP on transient pressure rises (T
Autor:
Christian Steinhäuser, Hidekazu Tanaka, Stefan Passlick, Hikaru Hashitani, Retsu Mitsui, Kenji F. Tanaka, Mitsuhiro Oishi, Ronald Jabs
Publikováno v:
British Journal of Pharmacology. 178:1073-1094
BACKGROUND AND PURPOSE While the bladder vasculature is considered as a target of PDE5 inhibitors to improve bladder storage dysfunctions, its characteristics are largely unknown. Thus, the functional and morphological properties of arteries/arteriol