Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration.

Autor: Ng B; National Heart Research Institute Singapore, National Heart Center Singapore, Singapore, Singapore. benjamin.ng.w.m@nhcs.com.sg.; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore. benjamin.ng.w.m@nhcs.com.sg., Huang KY; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Pua CJ; National Heart Research Institute Singapore, National Heart Center Singapore, Singapore, Singapore., Viswanathan S; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Lim WW; National Heart Research Institute Singapore, National Heart Center Singapore, Singapore, Singapore.; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Kuthubudeen FF; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Liu YN; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Hii AA; National Heart Research Institute Singapore, National Heart Center Singapore, Singapore, Singapore., George BL; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Widjaja AA; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore., Petretto E; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore.; Center for Computational Biology, Duke-National University of Singapore Medical School, Singapore, Singapore., Cook SA; National Heart Research Institute Singapore, National Heart Center Singapore, Singapore, Singapore. stuart.cook@duke-nus.edu.sg.; Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore. stuart.cook@duke-nus.edu.sg.; MRC-London Institute of Medical Sciences, Hammersmith Hospital Campus, London, United Kingdom. stuart.cook@duke-nus.edu.sg.

Publikováno v: Nature communications [Nat Commun] 2024 Oct 02; Vol. 15 (1), pp. 8530. Date of Electronic Publication: 2024 Oct 02.

Genetic Studies of Hypertrophic Cardiomyopathy in Singaporeans Identify Variants in TNNI3 and TNNT2 That Are Common in Chinese Patients.

Autor: Pua CJ; National Heart Centre Singapore (C.J.P., N.T., C.W.L.C., S.Q.L., S.C.K., P.M.L., A.A.H., C.X.Y., T.T.L., H.C.T., S.A.C.).; Yong Loo Lin School of Medicine, National University Singapore (C.J.P., L.Y.L.)., Tham N; National Heart Centre Singapore (C.J.P., N.T., C.W.L.C., S.Q.L., S.C.K., P.M.L., A.A.H., C.X.Y., T.T.L., H.C.T., S.A.C.)., Chin CWL; National Heart Centre Singapore (C.J.P., N.T., C.W.L.C., S.Q.L., S.C.K., P.M.L., A.A.H., C.X.Y., T.T.L., H.C.T., S.A.C.).; Duke-National University of Singapore Medical School (C.W.L.C., J.C., S.S.J., S.A.C.)., Walsh R; Department of Clinical and Experimental Cardiology, Heart Center, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, the Netherlands (R.W.)., Khor CC; Genome Institute of Singapore (C.C.K., P.T., R.F.)., Toepfer CN; Department of Genetics, Harvard Medical School, Boston, MA (C.N.T., G.G.R., A.C.G., K.P., G.V.S., A.C.P., J.G.S., C.E.S.).; Radcliffe Department of Medicine, University of Oxford, United Kingdom (C.N.T.)., Repetti GG; Department of Genetics, Harvard Medical School, Boston, MA (C.N.T., G.G.R., A.C.G., K.P., G.V.S., A.C.P., J.G.S., C.E.S.)., Garfinkel AC; Department of Genetics, Harvard Medical School, Boston, MA (C.N.T., G.G.R., A.C.G., K.P., G.V.S., A.C.P., J.G.S., C.E.S.)., Ewoldt JF; Department of Biomedical Engineering, Boston University, MA (J.F.E., P.C., C.S.C.)., Cloonan P; Department of Biomedical Engineering, Boston University, MA (J.F.E., P.C., C.S.C.)., Chen CS; Department of Biomedical Engineering, Boston University, MA (J.F.E., P.C., C.S.C.)., Lim SQ; National Heart Centre Singapore (C.J.P., N.T., C.W.L.C., S.Q.L., S.C.K., P.M.L., A.A.H., C.X.Y., T.T.L., H.C.T., S.A.C.)., Cai J; Duke-National University of Singapore Medical School (C.W.L.C., J.C., S.S.J., S.A.C.)., Loo LY; Yong Loo Lin School of Medicine, National University Singapore (C.J.P., L.Y.L.)., Kong SC; National Heart Centre Singapore (C.J.P., N.T., C.W.L.C., S.Q.L., S.C.K., P.M.L., A.A.H., C.X.Y., T.T.L., H.C.T., S.A.C.)., Chiang CWK; Center for Genetic Epidemiology, University of Southern California (C.W.K.C.).; Center for Neurobehavioral Genetics, University of California, Los Angeles (C.W.K.C.)., Whiffin N; Cardiovascular Research Center, Royal Brompton Hospital, London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.).; National Heart and Lung Institute, Imperial College London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.)., de Marvao A; Cardiovascular Research Center, Royal Brompton Hospital, London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.).; National Heart and Lung Institute, Imperial College London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.)., Lio PM; National Heart Centre Singapore (C.J.P., N.T., C.W.L.C., S.Q.L., S.C.K., P.M.L., A.A.H., C.X.Y., T.T.L., H.C.T., S.A.C.)., Hii AA; National Heart Centre Singapore (C.J.P., N.T., C.W.L.C., S.Q.L., S.C.K., P.M.L., A.A.H., C.X.Y., T.T.L., H.C.T., S.A.C.)., Yang CX; National Heart Centre Singapore (C.J.P., N.T., C.W.L.C., S.Q.L., S.C.K., P.M.L., A.A.H., C.X.Y., T.T.L., H.C.T., S.A.C.)., Le TT; National Heart Centre Singapore (C.J.P., N.T., C.W.L.C., S.Q.L., S.C.K., P.M.L., A.A.H., C.X.Y., T.T.L., H.C.T., S.A.C.)., Bylstra Y; SingHealth/Duke-NUS Precision Medicine Inst, Singapore (Y.B., W.K.L., J.X.T., P.T., S.S.J.)., Lim WK; SingHealth/Duke-NUS Precision Medicine Inst, Singapore (Y.B., W.K.L., J.X.T., P.T., S.S.J.)., Teo JX; SingHealth/Duke-NUS Precision Medicine Inst, Singapore (Y.B., W.K.L., J.X.T., P.T., S.S.J.)., Padilha K; Department of Genetics, Harvard Medical School, Boston, MA (C.N.T., G.G.R., A.C.G., K.P., G.V.S., A.C.P., J.G.S., C.E.S.).; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor)-University of São Paulo Medical School, Brazil (K.P., G.V.S., A.C.P.)., Silva GV; Department of Genetics, Harvard Medical School, Boston, MA (C.N.T., G.G.R., A.C.G., K.P., G.V.S., A.C.P., J.G.S., C.E.S.).; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor)-University of São Paulo Medical School, Brazil (K.P., G.V.S., A.C.P.)., Pan B; Cardiovascular Research Institute, National University Health System, Singapore (B.P., R.F.)., Govind R; Cardiovascular Research Center, Royal Brompton Hospital, London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.).; National Heart and Lung Institute, Imperial College London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.)., Buchan RJ; Cardiovascular Research Center, Royal Brompton Hospital, London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.).; National Heart and Lung Institute, Imperial College London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.)., Barton PJR; Cardiovascular Research Center, Royal Brompton Hospital, London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.).; National Heart and Lung Institute, Imperial College London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.)., Tan P; Genome Institute of Singapore (C.C.K., P.T., R.F.).; SingHealth/Duke-NUS Precision Medicine Inst, Singapore (Y.B., W.K.L., J.X.T., P.T., S.S.J.)., Foo R; Genome Institute of Singapore (C.C.K., P.T., R.F.).; Cardiovascular Research Institute, National University Health System, Singapore (B.P., R.F.)., Yip JWL; Cardiology Department, National University Heart Centre, Singapore (J.W.L.Y., R.C.C.W., W.X.C.)., Wong RCC; Cardiology Department, National University Heart Centre, Singapore (J.W.L.Y., R.C.C.W., W.X.C.)., Chan WX; Cardiology Department, National University Heart Centre, Singapore (J.W.L.Y., R.C.C.W., W.X.C.)., Pereira AC; Department of Genetics, Harvard Medical School, Boston, MA (C.N.T., G.G.R., A.C.G., K.P., G.V.S., A.C.P., J.G.S., C.E.S.).; Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor)-University of São Paulo Medical School, Brazil (K.P., G.V.S., A.C.P.)., Tang HC; National Heart Centre Singapore (C.J.P., N.T., C.W.L.C., S.Q.L., S.C.K., P.M.L., A.A.H., C.X.Y., T.T.L., H.C.T., S.A.C.)., Jamuar SS; Duke-National University of Singapore Medical School (C.W.L.C., J.C., S.S.J., S.A.C.).; National Heart and Lung Institute, Imperial College London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.).; KK Women's and Children's Hospital, Singapore (S.S.J.).; SingHealth Duke-NUS Genomic Medicine Centre, Singapore (S.S.J.)., Ware JS; Cardiovascular Research Center, Royal Brompton Hospital, London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.).; National Heart and Lung Institute, Imperial College London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.)., Seidman JG; Department of Genetics, Harvard Medical School, Boston, MA (C.N.T., G.G.R., A.C.G., K.P., G.V.S., A.C.P., J.G.S., C.E.S.)., Seidman CE; Department of Genetics, Harvard Medical School, Boston, MA (C.N.T., G.G.R., A.C.G., K.P., G.V.S., A.C.P., J.G.S., C.E.S.).; Cardiovascular Division, Brigham and Women's Hospital, Howard Hughes Medical Institute, Boston, MA (C.E.S.)., Cook SA; National Heart Centre Singapore (C.J.P., N.T., C.W.L.C., S.Q.L., S.C.K., P.M.L., A.A.H., C.X.Y., T.T.L., H.C.T., S.A.C.).; Duke-National University of Singapore Medical School (C.W.L.C., J.C., S.S.J., S.A.C.).; Cardiovascular Research Center, Royal Brompton Hospital, London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.).; National Heart and Lung Institute, Imperial College London, United Kingdom (N.W., A.d.M., R.G., R.J.B., P.J.R.B., J.S.W., S.A.C.).

Publikováno v: Circulation. Genomic and precision medicine [Circ Genom Precis Med] 2020 Oct; Vol. 13 (5), pp. 424-434. Date of Electronic Publication: 2020 Aug 20.