Pharmacological characterization of nicotine-induced tremor: Responses to anti-tremor and anti-epileptic agents

Autor: Naofumi Kunisawa, Saki Shimizu, Masaki Kato, Higor A. Iha, Chihiro Iwai, Mai Hashimura, Mizuki Ogawa, Shohei Kawaji, Kazuma Kawakita, Keisuke Abe, Yukihiro Ohno

Publikováno v: Journal of Pharmacological Sciences, Vol 137, Iss 2, Pp 162-169 (2018)

We previously showed that nicotine evoked kinetic tremor by activating the inferior olive, which is implicated in the pathogenesis of essential tremor, via α7 nicotinic acetylcholine receptors. Here, we evaluated the effects of various anti-tremor a

Externí odkaz: https://doaj.org/article/3bc0258570ed42c098040e8c66d73e7d

Engineered protein subunit COVID19 vaccine is as immunogenic as nanoparticles in mouse and hamster models

Autor: Melissa M. Matthews, Tae Gyun Kim, Keon Young Kim, Vladimir Meshcheryakov, Higor Alves Iha, Miho Tamai, Daiki Sasaki, Paola Laurino, Saacnicteh Toledo-Patiño, Mary Collins, Tzung-Yang Hsieh, Satoshi Shibata, Noriko Shibata, Fumiko Obata, Jun Fujii, Toshihiro Ito, Hiroshi Ito, Hiroki Ishikawa, Matthias Wolf

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

Abstract Initial studies on the immunogenicity of SARS-CoV-2 (CoV-2) S glycoprotein (“spike”) as a protein subunit vaccine suggested sub-optimal efficacy in mammals. Although protein engineering efforts have produced CoV-2 spike protein sequences

Externí odkaz: https://doaj.org/article/0177c76b3d834a7fb816ba77c81efaed

Mechanism Underlying Organophosphate Paraoxon-Induced Kinetic Tremor

Autor: Misaki Onishi, Chihiro Iwai, Mizuki Ogawa, Saki Shimizu, Naofumi Kunisawa, Higor A. Iha, Yukihiro Ohno, Masaki Kato, Nami Matsubara, Yuji Nomura, Kazuaki Sato, Mai Hashimura

Publikováno v: Neurotoxicity research. 35(3)

Organophosphates (OPs) inhibit cholinesterase and hyperactivate the acetylcholinergic nervous system in the brain, causing motor disorders (e.g., tremor and seizures). Here, we performed behavioral and immunohistochemical studies in mice and rats to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfa5105831e1c73d0abddc359c332593
https://pubmed.ncbi.nlm.nih.gov/30729450

Glycine-Binding Site Stimulants of NMDA Receptors Alleviate Extrapyramidal Motor Disorders by Activating the Nigrostriatal Dopaminergic Pathway

Autor: Higor A. Iha, Akiyoshi Inada, Shunsaku Sogabe, Saki Shimizu, Yukihiro Ohno, Ryoto Yanagisako, Megumi Yamanaka

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 18; Issue 7; Pages: 1416
International Journal of Molecular Sciences, Vol 18, Iss 7, p 1416 (2017)

Dysfunction of the N-methyl-d-aspartate (NMDA) receptor has been implicated in the pathogenesis of schizophrenia. Although agonists for the glycine-binding sites of NMDA receptors have potential as new medication for schizophrenia, their modulation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6235d882656478c34e95b0c97a30a23b
https://pubmed.ncbi.nlm.nih.gov/28671605

Nicotine Elicits Convulsive Seizures by Activating Amygdalar Neurons

Autor: Masato Kinboshi, Takahiro Mukai, Akio Ikeda, Naofumi Kunisawa, Kentaro Tokudome, Saki Shimizu, Tadao Serikawa, Higor A. Iha, Yukihiro Ohno, Hidefumi Ito

Publikováno v: Frontiers in Pharmacology

Nicotinic acetylcholine (nACh) receptors are implicated in the pathogenesis of epileptic disorders; however, the mechanisms of nACh receptors in seizure generation remain unknown. Here, we performed behavioral and immunohistochemical studies in mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb27111203a3c8e7809c1e6e8eaecf61