Výsledky vyhledávání - "High-fat diet (HFD)"

Akademický článek

Nobiletin restores HFD-induced enteric nerve injury by regulating enteric glial activation and the GDNF/AKT/FOXO3a/P21 pathway

Autor: Yueshan Pang, Li Zhang, Zhuoting Zhong, Ni Yang, Yali Zheng, Weijun Ding

Publikováno v: Molecular Medicine, Vol 30, Iss 1, Pp 1-15 (2024)

Abstract Background To explore whether nobiletin has a protective effect on high-fat diet (HFD)-induced enteric nerve injury and its underlying mechanism. Methods An obesity model was induced by a HFD. Nobiletin (100 mg/kg and 200 mg/kg) and vehicle

Externí odkaz: https://doaj.org/article/83973e5d652b4986bb5c4a85e59e5dfc

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Single-cell RNA-seq analysis decodes the kidney microenvironment induced by polystyrene microplastics in mice receiving a high-fat diet

Autor: Wenhao Xu, Shiqi Ye, Wangrui Liu, Huaqi Guo, Linhui Zhang, Shiyin Wei, Aihetaimujiang Anwaier, Kun Chang, Guilherme Malafaia, Hailiang Zhang, Dingwei Ye, Gang Wei

Publikováno v: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-21 (2024)

Abstract In recent years, the environmental health issue of microplastics has aroused an increasingly significant concern. Some studies suggested that exposure to polystyrene microplastics (PS-MPs) may lead to renal inflammation and oxidative stress

Externí odkaz: https://doaj.org/article/ae6667fb1e5e4dc5a27b17b710079786

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Akademický článek

Fenofibrate Ameliorates Retinal Pigment Epithelium Injury Induced by Excessive Fat Through Upregulation of PI3K/AKT Signaling

Autor: Wang X, Liu X, Tzekov R, Yu C, Yang J, Feng Y, Wu Y, Xu Y, Li S, Li W

Publikováno v: Drug Design, Development and Therapy, Vol Volume 17, Pp 3439-3452 (2023)

Xue Wang,1– 3 Xiaomei Liu,2 Radouil Tzekov,4 Chaofeng Yu,1 Jiasong Yang,1,5 Yuliang Feng,1 Yajun Wu,1 Yali Xu,1 Shiying Li,6 Wensheng Li1,5,7 1Aier School of Ophthalmology, Central South University, Changsha, People’s Republic of China; 2Suzhou I

Externí odkaz: https://doaj.org/article/66690b3c21dc4e8a80425379f4f9147f

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Akademický článek

Diet-mediated gut microbial community modulation and signature metabolites as potential biomarkers for early diagnosis, prognosis, prevention and stage-specific treatment of colorectal cancer

Autor: Mutebi John Kenneth, Hsin-Chi Tsai, Chuan-Yin Fang, Bashir Hussain, Yi-Chou Chiu, Bing-Mu Hsu

Publikováno v: Journal of Advanced Research, Vol 52, Iss , Pp 45-57 (2023)

Background: Over the last decade, studies have shown an increased incidence of colorectal cancer (CRC), particularly early onset colorectal cancer (EOCRC). Researchers have demonstrated that dietary behavior, especially among young adults, influences

Externí odkaz: https://doaj.org/article/523ec6f1032546b0aa4aca3ce86a058e

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Akademický článek

Glucokinase activator improves glucose tolerance and induces hepatic lipid accumulation in mice with diet-induced obesity

Autor: Nan Cai, Xuanrong Chen, Jia Liu, Zheyao Wen, Siyin Wen, Wen Zeng, Shuo Lin, Yanming Chen, Guojun Shi, Longyi Zeng

Publikováno v: Liver Research, Vol 7, Iss 2, Pp 124-135 (2023)

Background and aims: Type 2 diabetes mellitus remains a substantial medical problem with increasing global prevalence. Pharmacological research is becoming increasingly focused on personalized treatment strategies. Drug development based on glucokina

Externí odkaz: https://doaj.org/article/88a6b7fbbd1d44909d1bbd3b89f91a83

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Akademický článek

Lowering fasting blood glucose with non‐dialyzable material of cranberry extract is dependent on host genetic background, sex and diet

Autor: Fatima Amer‐Sarsour, Rana Tarabeih, Itzhak Ofek, Fuad A. Iraqi

Publikováno v: Animal Models and Experimental Medicine, Vol 6, Iss 3, Pp 196-210 (2023)

Abstract Background Type 2 diabetes (T2D) is a polygenic metabolic disease, characterized by high fasting blood glucose (FBG). The ability of cranberry (CRN) fruit to regulate glycemia in T2D patients is well known. Here, a cohort of 13 lines of the

Externí odkaz: https://doaj.org/article/51ef31095a494283af4b5e223c79bbbe

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Akademický článek

Obesity‐induced oxidative stress and mitochondrial dysfunction negatively affect sperm quality

Autor: Jia Jing, Yuanhong Peng, Weimin Fan, Siyang Han, Qihua Peng, Chunran Xue, Xinran Qin, Yue Liu, Zhide Ding

Publikováno v: FEBS Open Bio, Vol 13, Iss 4, Pp 763-778 (2023)

Obesity is a systemic metabolic disease that can induce male infertility or subfertility through oxidative stress. The aim of this study was to determine how obesity impairs sperm mitochondrial structural integrity and function, and reduces sperm qua

Externí odkaz: https://doaj.org/article/54f6fce1d4ac47cb88ece1b1606dacf5

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Maternal consumption of a high-fat diet modulates the inflammatory response in their offspring, mediated by the M1 muscarinic receptor

Autor: Suleyma Oliveira Costa, Wenicios Ferreira Chaves, Priscilla Karla Fernandes Lopes, Iracema M. Silva, Beatriz Burguer, Leticia M. Ignácio-Souza, Adriana Souza Torsoni, Marciane Milanski, Hosana Gomes Rodrigues, Mina Desai, Michael Glenn Ross, Marcio Alberto Torsoni

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionHigh-fat diet (HFD) consumption is associated with various metabolic disorders and diseases. Both pre-pregnancy and maternal obesity can have long-term consequences on offspring health. Furthermore, consuming an HFD in adulthood significa

Externí odkaz: https://doaj.org/article/c0d982e51e2148d9871b7c0e66f5ef81

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