Výsledky vyhledávání - "High mobility group box 1 (HMGB1)"

Akademický článek

Changes of serum high mobility group box 1 and soluble triggering receptor expressed on myeloid cells-1 in patients with multiple injuries and their prognostic significance

Autor: WANG Guijie, DU Chuanchong, LU Ye, ZHAO Jian, SHEN Xie, JIN Donglin, GENG Jiacai

Publikováno v: Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 44, Iss 3, Pp 350-357 (2024)

Objective·To detect the serum levels of high mobility group box 1 (HMGB1) and soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in patients with multiple injuries at different time points, and to analyze their correlation with disea

Externí odkaz: https://doaj.org/article/16c68a0571714cd199b28fb20d50de47

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Akademický článek

Research on the interaction of astragaloside IV and calycosin in Astragalus membranaceus with HMGB1

Autor: Junyi Ye, Yong Huang, Xuewa Jiang, Pingping Shen, Chaofeng Zhang, Jian Zhang

Publikováno v: Chinese Medicine, Vol 18, Iss 1, Pp 1-10 (2023)

Abstract Background High mobility group box 1 protein (HMGB1), a lethal late inflammatory mediator, contributes to the pathogenesis of diverse inflammatory and infectious diseases. Astragaloside IV and calycosin as active ingredients in Astragalus me

Externí odkaz: https://doaj.org/article/d9e19ecc5f3f4282a60ca34e79e55ef7

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Akademický článek

Detection of receptor for advanced glycation end products (RAGE) and high mobility group protein box 1 HMGB1 levels in patients’ serum with breast cancer

Autor: Hind Shawqi Zaki, Abdulsamie Hassan Alta’ee, Mushtaq Qahtan Mohammed

Publikováno v: Medical Journal of Babylon, Vol 20, Iss 4, Pp 847-851 (2023)

Background: Breast cancer (BC) is an unchecked proliferation of epithelial cells that begin in the breast lobules or ducts. BC develops and spreads as a result of the high mobility group protein box 1 (HMGB1). The survival, development, and metastasi

Externí odkaz: https://doaj.org/article/501380c86b4d404b9bdb3e4987c50003

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Akademický článek

Damage-associated molecular patterns in vitiligo: igniter fuse from oxidative stress to melanocyte loss

Autor: Jingying Wang, Yinghao Pan, Guangmin Wei, Hanxiao Mao, Rulan Liu, Yuanmin He

Publikováno v: Redox Report, Vol 27, Iss 1, Pp 193-199 (2022)

Objectives The pathogenesis of vitiligo remains unclear. In this review, we comprehensively describe the role of damage associated molecular patterns (DAMPs) during vitiligo pathogenesis.Methods Published papers on vitiligo, oxidative stress and DAMP

Externí odkaz: https://doaj.org/article/9ffc86970d6047658363d1f5784a2c53

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Akademický článek

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Akademický článek

HMGB1 is a critical molecule in the pathogenesis of Gram-negative sepsis

Autor: Ulf Andersson, Huan Yang

Publikováno v: Journal of Intensive Medicine, Vol 2, Iss 3, Pp 156-166 (2022)

Gram-negative sepsis is a severe clinical syndrome associated with significant morbidity and mortality. Lipopolysaccharide (LPS), expressed on Gram-negative bacteria, is a potent pro-inflammatory toxin that induces inflammation and coagulation via tw

Externí odkaz: https://doaj.org/article/59b160f9dab647cb867f2d66df97ed8b

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Akademický článek

Development of hepatic impairment aggravates chemotherapy-induced peripheral neuropathy following oxaliplatin treatment: Evidence from clinical and preclinical studies

Autor: Tomoyoshi Miyamoto, Risa Domoto, Fumiko Sekiguchi, Riki Kamaguchi, Rika Nishimura, Misato Matsuno, Maho Tsubota, Masanori Fujitani, Shigekatsu Hatanaka, Yuichi Koizumi, Dengli Wang, Masahiro Nishibori, Atsufumi Kawabata

Publikováno v: Journal of Pharmacological Sciences, Vol 148, Iss 3, Pp 315-325 (2022)

Oxaliplatin often induces peripheral neuropathy, a dose-limiting adverse reaction, and in rare cases leads to sinusoidal obstruction syndrome. We thus conducted a retrospective cohort study to examine the relationship between oxaliplatin-induced peri

Externí odkaz: https://doaj.org/article/ae80f6ce76474753aac680a6bbaefe92

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Akademický článek

Role of neuron-derived ATP in paclitaxel-induced HMGB1 release from macrophages and peripheral neuropathy

Autor: Risa Domoto, Fumiko Sekiguchi, Riki Kamaguchi, Maiko Iemura, Hiroki Yamanishi, Maho Tsubota, Dengli Wang, Masahiro Nishibori, Atsufumi Kawabata

Publikováno v: Journal of Pharmacological Sciences, Vol 148, Iss 1, Pp 156-161 (2022)

We examined the role of ATP and high mobility group box 1 (HMGB1) in paclitaxel-induced peripheral neuropathy (PIPN). PIPN in mice was prevented by HMGB1 neutralization, macrophage depletion, and P2X7 or P2X4 blockade. Paclitaxel and ATP synergistica

Externí odkaz: https://doaj.org/article/5c9863c762b644f49b16ef8614d4b4ff

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Akademický článek

Ferroptosis contribute to neonicotinoid imidacloprid-evoked pyroptosis by activating the HMGB1-RAGE/TLR4-NF-κB signaling pathway

Autor: Dongfang Zhang, Chunling Wu, Deyan Ba, Nan Wang, Yanling Wang, Xinlian Li, Qiuyue Li, Guifang Zhao

Publikováno v: Ecotoxicology and Environmental Safety, Vol 253, Iss , Pp 114655- (2023)

Imidacloprid (IMI) is among the common neonicotinoid insecticides used in agriculture worldwide, posing a potential toxic threat to non-target animals and humans. Numerous studies have shown that ferroptosis is involved in the pathophysiological prog

Externí odkaz: https://doaj.org/article/e65c95869f304c01b8e41bfe0a1091be

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