CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

Autor: Vennin, C, Melenec, P, Rouet, R, Nobis, M, Cazet, As, Murphy, Kj, Herrmann, D, Reed, Da, Lucas, Mc, Warren, Sc, Elgundi, Z, Pinese, M, Kalna, G, Roden, D, Samuel, M, Zaratzian, A, Grey, St, Da Silva, A, Leung, W, Mathivanan, S, Wang, Yx, Braithwaite, Aw, Christ, D, Benda, A, Parkin, A, Phillips, Pa, Whitelock, Jm, Gill, Aj, Sansom, Oj, Croucher, Dr, Parker, Bl, Pajic, M, Morton, Jp, Cox, Tr, Timpson, P, Johns, Al, Chantrill, La, Chou, A, Steinmann, A, Arshi, M, Dwarte, T, Froio, D, Pereira, B, Ritchie, S, Chambers, Cr, Metcalf, X, Waddell, N, Pearson, Jv, Patch, Am, Nones, K, Newell, F, Mukhopadhyay, P, Addala, V, Kazakoff, S, Holmes, O, Leonard, C, Wood, S, Grimmond, Sm, Hofmann, O, Christ, A, Bruxner, T, Samra, Js, Pavlakis, N, High, Ha, Asghari, R, Merrett, Nd, Pavey, D, Das, A, Cosman, Ph, Ismail, K, O'Connnor, C, Stoita, A, Williams, D, Spigellman, A, Lam, Vw, Mcleod, D, Kirk, J, Kench, Jg, Grimison, P, Cooper, Cl, Sandroussi, C, Goodwin, A, Mead, Rs, Tucker, K, Andrews, L, Texler, M, Forest, C, Epari, Kp, Ballal, M, Fletcher, Dr, Mukhedkar, S, Zeps, N, Beilin, M, Feeney, K, Nguyen, Nq, Ruszkiewicz, Ar, Worthley, C, Chen, J, Brooke-Smith, Me, Papangelis, V, Clouston, Ad, Barbour, Ap, O'Rourke, Tj, Fawcett, Jw, Slater, K, Hatzifotis, M, Hodgkinson, P, Nikfarjam, M, Eshleman, Jr, Hruban, Rh, Wolfgang, Cl, Lawlor, Rt, Beghelli, S, Corbo, V, Scardoni, M, Bassi, C, Biankin, Av, Dixon, J, Jamieson, Nb, Chang, Dk

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-22 (2019)
Nature Communications

Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic cancer tissues and can both promote and restrain disease progression. Here, we interrogate how cancer cells harboring distinct alterations in p53 manipulate CAFs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b639258f6d80adbf8b6d0ec03a3d9a
https://doaj.org/article/9cbe7f002204495db0cd437d4360e24c

Lost in translation: returning germline genetic results in genome-scale cancer research.

Autor: Johns AL; Cancer Research Program, Garvan Institute of Medical Research, Kinghorn Cancer Centre, Sydney, Australia., McKay SH; Cancer Research Program, Garvan Institute of Medical Research, Kinghorn Cancer Centre, Sydney, Australia., Humphris JL; Cancer Research Program, Garvan Institute of Medical Research, Kinghorn Cancer Centre, Sydney, Australia., Pinese M; Cancer Research Program, Garvan Institute of Medical Research, Kinghorn Cancer Centre, Sydney, Australia., Chantrill LA; Cancer Research Program, Garvan Institute of Medical Research, Kinghorn Cancer Centre, Sydney, Australia.; St Vincents Hospital, Darlinghurst, Australia.; Western Sydney University Clinical School, Sydney, Australia., Mead RS; Cancer Research Program, Garvan Institute of Medical Research, Kinghorn Cancer Centre, Sydney, Australia.; Genetics Department, SEALS Pathology, Prince of Wales Hospital, Randwick, Sydney, Australia.; School of Medicine, University of New South Wales, Sydney, Australia., Tucker K; Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, Sydney, Australia., Andrews L; Hereditary Cancer Clinic, Prince of Wales Hospital, Randwick, Sydney, Australia., Goodwin A; Cancer Genetics Department, Royal Prince Alfred Hospital and Liverpool Hospital, Sydney, NSW, Australia., Leonard C; QIMR Berghofer Medical Research Institute, Brisbane, Australia., High HA; Sydney Cancer Genetics, Sydney, Australia., Nones K; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Patch AM; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Merrett ND; Department of Surgery, Bankstown Hospital, Eldridge Road, Bankstown, Sydney, Australia.; Division of Surgery, School of Medicine, Western Sydney University, Sydney, Australia., Pavlakis N; Department of Medical Oncology, Royal North Shore Hospital and Faculty of Medicine, University of Sydney, Sydney, Australia., Kassahn KS; Genetic and Molecular Pathology, SA Pathology, Women's and Children's Hospital, North Adelaide, Adelaide, Australia., Samra JS; Department of Surgery, Royal North Shore Hospital, Sydney, Australia., Miller DK; Illumina Inc, 5200 Illumina Way, San Diego, CA, 92122, USA., Chang DK; Cancer Research Program, Garvan Institute of Medical Research, Kinghorn Cancer Centre, Sydney, Australia.; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow, Scotland, UK.; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK.; Department of Surgery, Bankstown Hospital, Eldridge Road, Bankstown, Sydney, Australia.; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, Australia., Pajic M; Cancer Research Program, Garvan Institute of Medical Research, Kinghorn Cancer Centre, Sydney, Australia., Pearson JV; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Grimmond SM; University of Melbourne, Parkville, Australia., Waddell N; QIMR Berghofer Medical Research Institute, Brisbane, Australia., Zeps N; St John of God Subiaco, Perth, Australia.; School of Surgery, The University of Western Australia, Perth, Australia., Gill AJ; Cancer Research Program, Garvan Institute of Medical Research, Kinghorn Cancer Centre, Sydney, Australia.; Cancer Diagnosis and Pathology Group, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney Australia and University of Sydney, Sydney, Australia., Biankin AV; Cancer Research Program, Garvan Institute of Medical Research, Kinghorn Cancer Centre, Sydney, Australia. andrew.biankin@glasgow.ac.uk.; West of Scotland Pancreatic Unit, Glasgow Royal Infirmary, Glasgow, UK. andrew.biankin@glasgow.ac.uk.; South Western Sydney Clinical School, Faculty of Medicine, University of New South Wales, Liverpool, Australia. andrew.biankin@glasgow.ac.uk.; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Switchback Road, Bearsden, Glasgow, UK. andrew.biankin@glasgow.ac.uk.

Publikováno v: Genome medicine [Genome Med] 2017 Apr 28; Vol. 9 (1), pp. 41. Date of Electronic Publication: 2017 Apr 28.