Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Higbee Jared Martin"'
Autor:
Van Phung, Higbee Jared Martin, Marilyn Wang, Rowena Suriben, Yan Wang, Dina A. Ayupova, Diana Li, Hung-I Harry Chen, Subhash D. Katewa, André O. White, Zhengyu Gao, Michele McEntee, Andrea Olland, Damodharan Lakshminarasimhan, Richard Ventura, Michael Chen, Julie Oeffinger, Jie Tang, Shelley R. Starck, Jer-Yuan Hsu, Darrin A. Lindhout, Pranali Taskar, Kalyani Mondal, Mark J. Solloway, Raj Haldankar, Avantika Kekatpure, Bernard B. Allan, Betty Chan Li
Publikováno v:
Nature medicine. 26(8)
Cancer cachexia is a highly prevalent condition associated with poor quality of life and reduced survival1. Tumor-induced perturbations in the endocrine, immune and nervous systems drive anorexia and catabolic changes in adipose tissue and skeletal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c6269b35aef81f42e7c7d2627e1afde
https://pubmed.ncbi.nlm.nih.gov/32877689
https://pubmed.ncbi.nlm.nih.gov/32877689
Autor:
Kalyani Mondal, Geoffrey Horner, Manuel E. Lopez, Mark J. Solloway, Chen M, Laird T, Gao Z, Raj Haldankar, Andre White, Yao J, Wang M, Tang J, Avantika Kekatpure, Hugo Matern, Bernard B. Allan, Chan J, Alice Chen Y, Dina A. Ayupova, Higbee Jared Martin, Damodharan Lakshminarasimhan, Li B, Tian H, To C, Hsu Jy, Alan Kutach, Tom Parsons, Wang Sp, Shen Wd, Suzanne Christine Crawley, Joo W, Junming Yie, Darrin A. Lindhout, cEntee M, Fu D
Publikováno v:
Nature. 550:255-259
Under homeostatic conditions, animals use well-defined hypothalamic neural circuits to help maintain stable body weight, by integrating metabolic and hormonal signals from the periphery to balance food consumption and energy expenditure. In stressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a4a24186b546405f4cc938c49643d3
https://doi.org/10.1038/nature24042
https://doi.org/10.1038/nature24042
Autor:
Marc W. Retter, Mark Leo Michaels, Derek E. Piper, Katherine C Matsuda, Lei Zhou, Chadwick T. King, Wei Wang, Higbee Jared Martin, Jeonghoon Sun, Howard Monique L, Simon Jackson, Ren Xu, Randal R. Ketchem, Brandon Ason, Jie Tang, Kirk Henne, Joyce Chi Yee Chan
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 353(1)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as an attractive therapeutic target for cardiovascular disease. Monoclonal antibodies (mAbs) that bind PCSK9 and prevent PCSK9:low-density lipoprotein receptor complex formation reduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f51d0f83b17b3574d22d7dc84b3f51
https://pubmed.ncbi.nlm.nih.gov/25653417
https://pubmed.ncbi.nlm.nih.gov/25653417
Autor:
Xiao-Ping Yang, Zhen Xia, Higbee Jared Martin, Athena Sudom, Timothy Yu, Sheree Johnstone, Wenyan Shen, Xiaoshan Min, Ping Cao, Hua Tu, Jiangwen Majeti, Hui Shao, Nigel Walker, Qiang Liu, Yan Wang, Yi Zhang, Wei Wang, Zhulun Wang, Mei Lu, Yumei Xiong, Nik Sharkov, Jie Tang
Dipeptidyl peptidase IV (DPP-IV) degrades the incretin hormone glucagon-like peptide 1 (GLP-1). Small molecule DPP-IV inhibitors have been used as treatments for type 2 diabetes to improve glucose tolerance. However, each of the marketed small molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5175260aaba3b77481a1c37239624d46
https://europepmc.org/articles/PMC3543014/
https://europepmc.org/articles/PMC3543014/
Autor:
Higbee Jared Martin, Bei Shan, Margrit Schwarz, Wen-Chen Yeh, William G. Romanow, Qiong Cao, Mei Lu, Joyce Chi Yee Chan, Richard Zhang, Yongmei Di, Ping Cao, Maurice Emery, Evelyn Yang, Stephen T. Thibault, Lei Zhou, Susan Shetterly, Gayle Kwon, Timothy W. Yu, Dongming Liu, Wenyan D. Shen, Kirk Henne, Oscar Pan, Mei-Mei Tsai, Heather Salomonis, Bryna Fuchslocher, Ziva Arimura, Nigel Walker, Qiang Liu, Mark Daris, Derek E. Piper, Kijeong Lee, Simon Mark Jackson, Wei Wang, Chadwick T. King, Jie Tang, Xiao-Ping Yang, Jackie Sheng, Yan Wang, Marc W. Retter, Zhen Xia
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 106(24)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates serum LDL cholesterol (LDL-C) by interacting with the LDL receptor (LDLR) and is an attractive therapeutic target for LDL-C lowering. We have generated a neutralizing anti-PCSK9 antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6547ec9849672f16af5dab324c2e1c67
https://pubmed.ncbi.nlm.nih.gov/20425252
https://pubmed.ncbi.nlm.nih.gov/20425252