Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Higashida Susumu"'
Autor:
Takashi Nishigaki, Ryuichi Yagi, Hiroshi Mohri, Hiroshi Handa, Hisayo Suzuki-Sunagawa, Mitsuya Sakurai, Kaoru Shimada, Higashida Susumu, Shinichi Oka, Tomoaki Komai, Akira Yasuoka, Satoshi Kimura, Yuichiro Yabe, Machiko Sugano
Publikováno v:
Biological and Pharmaceutical Bulletin. 20:175-180
In a series of compounds containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA), a transitionstate mimetic, R-87366:(2S,3S)-3-[N-(quinoxaline-2-carbonyl)-L-asparaginyl]amino- 2-hydroxy-4-phenylbutanoyl-L-proline tert-butylamide, was found
Autor:
Shuichi Miyamaoto, Atsushi Kasuya, A Yasuoka, Yuji Ozawa, Takashi Nishigaki, Satoshi Kimura, Yuichiro Yabe, Hiroshi Handa, Tamayo Nitta, Kaoru Shimada, Shinichi Oka, Higashida Susumu, Ryuichi Yagi, Mitsuya Sakurai, Hiroshi Mohri, Tomoaki Komai
Publikováno v:
Bioorganicmedicinal chemistry. 4(8)
Systematic replacement in the 3- or 4-position of the pyrrolidine ring at P1' proline was carried out. Compound 26, which has a Cl atom in the 4(S)-position was the most active among inhibitors substituted with other halogen atoms or other substituen
Autor:
Takashi Nishigaki, Yuichiro Yabe, Machiko Sugano, Mitsuya Sakurai, Ryuichi Yagi, Hiroshi Handa, Higashida Susumu, Yuji Ozawa, Tomoaki Komai
Publikováno v:
Bioorganicmedicinal chemistry. 2(8)
A series of Human Immunodeficiency Virus type-1 protease (HIV-1 PR) inhibitors that contain 3-amino-2-hydroxy-4-phenylbutanoic acid (AHPBA) at the scission site of the substrate were prepared and evaluated for their inhibitory activity. Preliminary s
Autor:
Takashi Nishigaki, Yuichiro Yabe, Ryuichi Yagi, Machiko Sugano, Tomoaki Komai, Mitsuya Sakurai, Higashida Susumu, Hiroshi Handa
Publikováno v:
Chemicalpharmaceutical bulletin. 42(3)
Systematic replacement of the P4-P2 subsites of substrate-based human immunodeficiency virus type 1 protease (HIV-1 PR) inhibitors containing cyclohexylalanylalanine hydroxyethylene dipeptide isostere (Cha-psi [H.E.]-Ala) at positions corresponding t
Autor:
Takahide Nishi, Fujio Saito, Hiroshi Handa, Mitsuya Sakurai, Takashi Nishigaki, Yuichiro Yabe, Tomoaki Komai, Machiko Sugano, Yasuo Ohata, Ryuichi Yagi, Higashida Susumu
Publikováno v:
Chemicalpharmaceutical bulletin. 41(8)
Human immunodeficiency virus type 1 (HIV-1) protease inhibitors containing four types of hydroxyethylene dipeptide isosteres were designed and synthesized. These inhibitors consist of eight stereoisomers of phenylalanylproline (Phe-psi[H.E.]-Pro), fo
Autor:
Takashi Nishigaki, Ryuichi Yagi, Shuichi Miyamoto, Mitsuya Sakurai, Yuichiro Yabe, Machiko Sugano, Hiroshi Handa, Atsushi Kasuya, Higashida Susumu, Tomoaki Komai
Publikováno v:
Peptide Chemistry 1992 ISBN: 9789401046480
Peptide Chemistry 1992
Peptide Chemistry 1992
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7eb8c388c5b3b50f1def28ad2363b11
https://doi.org/10.1007/978-94-011-1474-5_155
https://doi.org/10.1007/978-94-011-1474-5_155
Autor:
Higashida Susumu, Rei Matsueda
Publikováno v:
HETEROCYCLES. 52:511
Autor:
Kunio Hiwada, Yuichiro Yabe, Higashida Susumu, Tatsuo Kokubu, Eiki Murakami, Yoichi Imamura, Hiroshi Kogen, Rei Matsueda, Hiroyuki Koike, Yasuteru Iijima
Publikováno v:
Chemistry Letters. 14:1041-1044
The phenylalanine residue in the C-terminal sequence of angiotensin II was found to be important for the design of renin inhibitors. 1-Naphthyl-alanine(Nal(1))-containing tripeptide analogues such as benzyloxycarbonyl-Nal (1)-His-Leucinal (ES-188) an
Autor:
Matsueda, Rei, Yabe, Yuichiro, Kogen, Hiroshi, Higashida, Susumu, Koike, Hiroyuki, Iijima, Yasuteru, Kokubu, Tatsuo, Hiwada, Kunio, Murakami, Eiki, Imamura, Yoichi
Publikováno v:
Chemistry Letters; July 1985, Vol. 14 Issue: 7 p1041-1044, 4p
Publikováno v:
Chemistry Letters; June 1982, Vol. 11 Issue: 6 p921-924, 4p