Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization

Autor: Gold, MJ, Hiebert, PR, Park, HY, Stefanowicz, D, Le, A, Starkey, MR, Deane, A, Brown, AC, Liu, G, Horvat, JC, Ibrahim, ZA, Sukkar, MB, Hansbro, PM, Carlsten, C, Vaneeden, S, Sin, DD, McNagny, KM, Knight, DA, Hirota, JA

Exposure to particulate matter (PM), a major component of air pollution, contributes to increased morbidity and mortality worldwide. PM induces innate immune responses and contributes to allergic sensitization, although the mechanisms governing this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______363::33d1d53eddc9ba99e8dc01fb997291a9
https://hdl.handle.net/10453/74189

Mucosal production of uric acid by airway epithelial cells contributes to particulate matter-induced allergic sensitization.

Autor: Gold MJ; Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada., Hiebert PR; James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada., Park HY; Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Stefanowicz D; James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada., Le A; James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada., Starkey MR; Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia., Deane A; Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia., Brown AC; Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia., Liu G; Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia., Horvat JC; Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia., Ibrahim ZA; Discipline of Pharmacy, Graduate School of Health, The University of Technology Sydney, Sydney, Australia.; Woolcock Institute of Medical Research, Sydney Medical School, The University of Sydney, Sydney, Australia., Sukkar MB; Discipline of Pharmacy, Graduate School of Health, The University of Technology Sydney, Sydney, Australia.; Woolcock Institute of Medical Research, Sydney Medical School, The University of Sydney, Sydney, Australia., Hansbro PM; Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia., Carlsten C; James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Coastal Health Research Institute, Vancouver General Hospital, Vancouver, British Columbia, Canada., VanEeden S; James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada., Sin DD; James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada., McNagny KM; Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada., Knight DA; Priority Research Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, University of Newcastle, Callaghan, Australia.; School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, Australia.; Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada., Hirota JA; James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada.; Vancouver Coastal Health Research Institute, Vancouver General Hospital, Vancouver, British Columbia, Canada.

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Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice.

Autor: Hiebert PR; UBC James Hogg Research Centre, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada., Wu D, Granville DJ

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Granzyme B in injury, inflammation, and repair.

Autor: Hiebert PR; UBC James Hogg Research Centre, University of British Columbia, 166-1081 Burrard Street, Vancouver, British Columbia, V6Z 1Y6, Canada., Granville DJ

Publikováno v: Trends in molecular medicine [Trends Mol Med] 2012 Dec; Vol. 18 (12), pp. 732-41. Date of Electronic Publication: 2012 Oct 22.

Granzymes in age-related cardiovascular and pulmonary diseases.

Autor: Hendel A; Department of Pathology and Laboratory Medicine, Providence Heart+Lung Institute, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada., Hiebert PR, Boivin WA, Williams SJ, Granville DJ

Publikováno v: Cell death and differentiation [Cell Death Differ] 2010 Apr; Vol. 17 (4), pp. 596-606. Date of Electronic Publication: 2010 Feb 05.