Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hideyuki Tozaki"'
Autor:
Akira Yamamoto, Junta Komoike, Sooh‐Ih Kim, Hiroshi Terashima, Shozo Muranishi, Hideyuki Tozaki, Junko Nishioka, Takuya Fujita, Naoki Okada
Publikováno v:
Journal of Pharmaceutical Sciences. 90:89-97
The objective of this study was to estimate colon‐specific delivery of insulin and (Asu 1,7 )eel‐calcitonin using novel azopolymer‐coated pellets. In vitro drug‐release experiments from the azopolymer‐coated pellets containing fluorescein i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d00bace871a107af7edffe770eab9af
https://doi.org/10.1002/1520-6017(200101)90:1<89::aid-jps10>3.3.co
https://doi.org/10.1002/1520-6017(200101)90:1<89::aid-jps10>3.3.co
Autor:
Akira Terabe, Chiyuki Tanaka, Susumu Okabe, Shozo Muranishi, Takuya Fujita, Tomokazu Odoriba, Hideyuki Tozaki, Tsutomu Suzuki, Akira Yamamoto
Publikováno v:
Life Sciences. 64:1155-1162
The objective of this study was to estimate the therapeutic effects of R68070, a new thromboxane synthase inhibitor, on 2,4,6-trinitrobenzenesulfonic acid sodium salt (TNBS)-induced ulcerative colitis in rats. We also examined the acceleration of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deda7f5db99765a5fd3684f657ceafad
https://doi.org/10.1016/s0024-3205(99)00044-2
https://doi.org/10.1016/s0024-3205(99)00044-2
Autor:
Takuya Fujita, Isao Sasaki, Yukiko Ito, Keiko Matsumoto, Masahiro Murakami, Hideyuki Tozaki, Akira Yamamoto, Shozo Muranishi
Publikováno v:
Biological and Pharmaceutical Bulletin. 22:611-615
The effects of formulation factors on the enhancement of colonic absorption of azetirelin by n-lauryl-beta-maltopyranoside (LM) were studied in rats. Coadministration of LM with a small volume of azetirelin solution to the proximal colon increased th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619efa273ca1d3f005fdaaa01d5f17a7
https://doi.org/10.1248/bpb.22.611
https://doi.org/10.1248/bpb.22.611
Autor:
Toshio Taniguchi, Shozo Muranishi, Masahiro Murakami, Akira Yamamoto, Hideyuki Tozaki, Tomokazu Odoriba, Tomoya Iseki, Takuya Fujita
Publikováno v:
Journal of Pharmacy and Pharmacology. 50:913-920
The objective of this study was to examine the effects of protease inhibitors on the absorption of calcitonin from different regions of the intestine in rats. The absorption experiments were investigated by in-situ use of closed intestinal loops in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba310e5ff85ef6ea1eced4e0fc1d297
https://doi.org/10.1111/j.2042-7158.1998.tb04008.x
https://doi.org/10.1111/j.2042-7158.1998.tb04008.x
Publikováno v:
Drug Delivery System. 12:311-320
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60ca3c01e49ff892d97980f131c8b8d5
https://doi.org/10.2745/dds.12.311
https://doi.org/10.2745/dds.12.311
Autor:
Akira Yamamoto, Takayuki Matsumoto, Akira Terabe, Tsutomu Suzuki, Hideyuki Tozaki, Shozo Muranishi, Takuya Fujita
Publikováno v:
Drug Metabolism and Pharmacokinetics. 10:88-91
Recently, there is increasing interest in the targeting of these drugs to the colon because of the low activity of proteolytic enzymes in the colon. Therefore, many dosage forms such as a time controlled-release dosage form and a pH-sensitive coating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5b5231516176aa5772178b2f5a7604
https://doi.org/10.2133/dmpk.10.supplement_88
https://doi.org/10.2133/dmpk.10.supplement_88
Publikováno v:
Biological and Pharmaceutical Bulletin. 18:929-931
The metabolism of insulin and calcitonin by microorganisms was examined in rat cecal contents. Both insulin and calcitonin were markedly degraded. Calcitonin was more susceptible to proteolysis in rat cecal contents than insulin. Calcitonin was also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f69dc9dbada2470af7b4825d720acc
https://doi.org/10.1248/bpb.18.929
https://doi.org/10.1248/bpb.18.929
Autor:
Shozo Muranishi, Takuya Fujita, Naoki Okada, Hideyuki Tozaki, Akira Yamamoto, Tsutomu Suzuki, Akira Terabe, Tomokazu Odoriba, Susumu Okabe
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 82(1)
The objective of this study was to achieve the colon-specific delivery of an anti-ulcerative colitis drug using chitosan capsules and to accelerate healing of 2,4,6-trinitrobenzene sulfonic acid sodium salt (TNBS)-induced colitis in rats. 5-Aminosali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f377914ae46e70c38d84c72b17e2f8
https://pubmed.ncbi.nlm.nih.gov/12106976
https://pubmed.ncbi.nlm.nih.gov/12106976
Autor:
Akira Yamamoto, Takuya Fujita, Akira Terabe, Susumu Okabe, Hideyuki Tozaki, Tomokazu Odoriba, Shozo Muranishi
Publikováno v:
The Journal of pharmacy and pharmacology. 51(10)
A pharmacokinetic model of colon-specific drug delivery developed in a previous study has been validated by use of 5-aminosalicylic acid (5-ASA) as a model anti-inflammatory drug. The simulation curves obtained from the pharmacokinetic model were in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba9d354f3681ca3154f0111f438e4a2
https://pubmed.ncbi.nlm.nih.gov/10579681
https://pubmed.ncbi.nlm.nih.gov/10579681
Autor:
Sooh‐Ih Kim, Takuya Fujita, Akira Yamamoto, Shozo Muranishi, Susumu Okabe, Hideyuki Tozaki, Junta Komoike, Hiroshi Terashima
Publikováno v:
The Journal of pharmacy and pharmacology. 51(3)
The objective of this study was to achieve colon-specific delivery of budesonide using azopolymer-coated pellets and to accelerate healing of 2,4,6-trinitrobenzenesulphonic acid sodium salt (TNBS)-induced colitis in rats. After oral administration of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae74425a73c8eded424eb959f131224
https://pubmed.ncbi.nlm.nih.gov/10344625
https://pubmed.ncbi.nlm.nih.gov/10344625