Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Hideyuki Nakashima"'
Publikováno v:
Epigenomes, Vol 8, Iss 2, p 22 (2024)
The development of the nervous system is regulated by numerous intracellular molecules and cellular signals that interact temporally and spatially with the extracellular microenvironment. The three major cell types in the brain, i.e., neurons and two
Externí odkaz:
https://doaj.org/article/84e450d439df4e00b7b85d00a231afae
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Epilepsy is a chronic neurological disorder characterized by hypersynchronous spontaneous recurrent seizures, and affects approximately 50 million people worldwide. Cumulative evidence has revealed that epileptogenic insult temporarily increases neur
Externí odkaz:
https://doaj.org/article/89459b618de14e6c9f3e37111963e407
Autor:
Tomonori KAMEDA, Hideyuki NAKASHIMA, Takumi TAKIZAWA, Fumihito MIURA, Takashi ITO, Kinichi NAKASHIMA, Takuya IMAMURA
Publikováno v:
The Journal of Reproduction and Development, Vol 67, Iss 6, Pp 369-379 (2021)
Post-mitotic neurons do exhibit DNA methylation changes, contrary to the longstanding belief that the epigenetic pattern in terminally differentiated cells is essentially unchanged. While the mechanism and physiological significance of DNA demethylat
Externí odkaz:
https://doaj.org/article/05bf0e296b3d45e495e3c006aa04c7f3
Autor:
Shin Kato, Osuke Iwata, Yasumasa Yamada, Hiroki Kakita, Takaharu Yamada, Hideyuki Nakashima, Tokio Sugiura, Satoshi Suzuki, Hajime Togari
Publikováno v:
Pediatrics and Neonatology, Vol 61, Iss 1, Pp 100-105 (2020)
Background: Phototherapy with radiation of 460–490 nm wavelengths provides the most potent therapeutic effect for neonatal jaundice. However, the efficacy of phototherapy has been estimated using single-wavelength detectors with sensitivity at appr
Externí odkaz:
https://doaj.org/article/5a7b42331e234d0fa43f1ad4eaf68fb1
Growth factors with valproic acid restore injury-impaired hearing by promoting neuronal regeneration
Autor:
Takahiro Wakizono, Hideyuki Nakashima, Tetsuro Yasui, Teppei Noda, Kei Aoyagi, Kanako Okada, Yasuhiro Yamada, Takashi Nakagawa, Kinichi Nakashima
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Spiral ganglion neurons (SGNs) are primary auditory neurons in the spiral ganglion that transmit sound information from the inner ear to the brain and play an important role in hearing. Impairment of SGNs causes sensorineural hearing loss (SNHL), and
Externí odkaz:
https://doaj.org/article/b9e5695f8d1840c0afc707ee61da6105
Autor:
Hideyuki Nakashima, Keita Tsujimura, Koichiro Irie, Takuya Imamura, Cleber A. Trujillo, Masataka Ishizu, Masahiro Uesaka, Miao Pan, Hirofumi Noguchi, Kanako Okada, Kei Aoyagi, Tomoko Andoh-Noda, Hideyuki Okano, Alysson R. Muotri, Kinichi Nakashima
Publikováno v:
Cell Reports, Vol 35, Iss 7, Pp 109124- (2021)
Summary: Rett syndrome (RTT) is a severe neurological disorder, with impaired brain development caused by mutations in MECP2; however, the underlying mechanism remains elusive. We know from previous work that MeCP2 facilitates the processing of a spe
Externí odkaz:
https://doaj.org/article/0fed81b11b5247d3a98746060e307b29
Autor:
Yuichiro Hayashi, Kenji Mitsudo, Kaname Sakuma, Masaki Iida, Toshinori Iwai, Hideyuki Nakashima, Yoshiyuki Okamoto, Toshiyuki Koizumi, Senri Oguri, Makoto Hirota, Mitomu Kioi, Izumi Koike, Masaharu Hata, Iwai Tohnai
Publikováno v:
Radiation Oncology, Vol 12, Iss 1, Pp 1-8 (2017)
Abstract Background The aim of this retrospective observational study was to evaluate toxicities, overall survival, and locoregional control in elderly oral squamous cell carcinoma patients who had undergone retrograde intra-arterial chemotherapy com
Externí odkaz:
https://doaj.org/article/e1c3ebe21f264bdcb83df5c09ff07ea1
Autor:
Tetsuro Yasui, Naohiro Uezono, Hideyuki Nakashima, Hirofumi Noguchi, Taito Matsuda, Tomoko Noda-Andoh, Hideyuki Okano, Kinichi Nakashima
Publikováno v:
Stem Cell Reports, Vol 8, Iss 6, Pp 1743-1756 (2017)
Human neural precursor cells (hNPCs) derived from pluripotent stem cells display a high propensity for neuronal differentiation, but they require long-term culturing to differentiate efficiently into astrocytes. The mechanisms underlying this biased
Externí odkaz:
https://doaj.org/article/0f00bf27765c49758f1a91e16d5b6625
Publikováno v:
SAGE Open Medical Case Reports, Vol 7 (2019)
Acquired bronchial stenosis is rare in children, usually caused by infection or traumatic granuloma due to chronic intubation. A case of severe acquired left bronchial stenosis successfully treated by conservative management for gastroesophageal refl
Externí odkaz:
https://doaj.org/article/d77575b0a79d423796221082b215c8f2
Autor:
Keita Tsujimura, Koichiro Irie, Hideyuki Nakashima, Yoshihiro Egashira, Yoichiro Fukao, Masayuki Fujiwara, Masayuki Itoh, Masahiro Uesaka, Takuya Imamura, Yasukazu Nakahata, Yui Yamashita, Takaya Abe, Shigeo Takamori, Kinichi Nakashima
Publikováno v:
Cell Reports, Vol 12, Iss 11, Pp 1887-1901 (2015)
Rett syndrome (RTT) is a neurodevelopmental disorder caused by MECP2 mutations. Although emerging evidence suggests that MeCP2 deficiency is associated with dysregulation of mechanistic target of rapamycin (mTOR), which functions as a hub for various
Externí odkaz:
https://doaj.org/article/686c56aae0c14514844775a62c0f01ca