Výsledky vyhledávání - "Hideyasu Ikemoto"

Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells

Autor: Hirokazu Fujikawa, Norio Arita, Kazuyoshi Tamura, Masayuki Yokota, Kanji Mori, Hideyasu Ikemoto, Isao Ozaki, Yonehiro Kanemura, Tsuyoshi Matsumoto, Atsuhisa Nakano

Publikováno v: Neuroscience Research. 43:69-74

Brain-specific angiogenesis inhibitor 1 (BAI1) is a p53-target gene specifically expressed in the brain. We examined the distribution of the endogenous BAI1 protein in normal human brain tissue using a polyclonal antibody against the extracellular re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22f66bb6ff150296cbb60620aa5cb95c
https://doi.org/10.1016/s0168-0102(02)00018-4

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Calphostin C-mediated translocation and integration of Bax into mitochondria induces cytochrome c release before mitochondrial dysfunction

Autor: Norio Arita, Eiichi Tani, Hideyasu Ikemoto, Hiroyuki Kitagawa, Isao Ozaki

Publikováno v: Cell Death & Differentiation. 7:511-520

Calphostin C-mediated apoptosis in glioma cells was reported previously to be associated with down-regulation of Bcl-2 and Bcl-xL. In this study, we report that 100 nM calphostin C also induces translocation and integration of monomeric Bax into mito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f832464bece9f06edfc42516d44b622d
https://doi.org/10.1038/sj.cdd.4400682

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Activation of Stress-activated Protein Kinase/c-Jun NH2-terminal Kinase and p38 Kinase in Calphostin C-induced Apoptosis Requires Caspase-3-like Proteases but Is Dispensable for Cell Death

Autor: Eiichi Tani, Isao Ozaki, Hideyasu Ikemoto, Hirokazu Fujikawa, Hiroyuki Kitagawa

Publikováno v: Journal of Biological Chemistry. 274:5310-5317

Apoptosis was induced in human glioma cell lines by exposure to 100 nm calphostin C, a specific inhibitor of protein kinase C. Calphostin C-induced apoptosis was associated with synchronous down-regulation of Bcl-2 and Bcl-xL as well as activation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4812d9a8d6d0add0f655f2f33345ccd6
https://doi.org/10.1074/jbc.274.9.5310

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Proteasome inhibitors induce mitochondria-independent apoptosis in human glioma cells

Autor: Hideyasu Ikemoto, Hiroyuki Kitagawa, Atsuhisa Nakano, Isao Ozaki, Eiichi Tani, Satoshi Omura

Publikováno v: FEBS Letters. 443:181-186

The proteasome inhibitors lactacystin and AcLLNal induced p53-independent apoptosis in two human glioma cell lines, and the apoptosis was accompanied by up-regulation of immunoreactive wild-type p53, p21Waf1, Mdm2, and p27Kip1. Pretreatment with cycl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e90c19fa674943739372a610aae930
https://doi.org/10.1016/s0014-5793(98)01709-8

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Apoptosis of human glioma cells in response to calphostin C, a specific protein kinase C inhibitor

Autor: Eiichi Tani, Jun-ichi Furuyama, Atsuhisa Nakano, Tsuyoshi Matsumoto, Hideyasu Ikemoto

Publikováno v: Journal of Neurosurgery. 83:1008-1016

✓ Calphostin C acts at the regulatory domain as a highly selective inhibitor of protein kinase C (PKC), and staurosporine acts at the catalytic domain as a nonspecific PKC inhibitor. The authors investigated the capacity of calphostin C and stauros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38b2e999b1b8ac8217b3c9c992ba692
https://doi.org/10.3171/jns.1995.83.6.1008

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Inhibition by 5'-methylthioadenosine of cell growth and tyrosine kinase activity stimulated by fibroblast growth factor receptor in human gliomas

Autor: Atsuhisa Nakano, Eiichi Tani, Hideyasu Ikemoto, Katsuya Miyaji, Keizo Kaba

Publikováno v: Journal of neurosurgery. 83(4)

✓ Stimulation of three human glioma cell lines with basic fibroblast growth factor (bFGF) led to the enhancement of cell growth and the rapid tyrosine phosphorylation of cellular proteins, including major substrates of 90 kD. A methyltransferase in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3ede42e9417663c5a75572d8fabafa
https://pubmed.ncbi.nlm.nih.gov/7545743

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