Zobrazeno 1 - 10
of 342
pro vyhledávání: '"Hidetsugu Saito"'
Autor:
Akihiko Ikura, Po‐sung Chu, Nobuhiro Nakamoto, Keisuke Ojiro, Nobuhito Taniki, Aya Yoshida, Masahiro Shinoda, Rei Morikawa, Karin Yamataka, Fumie Noguchi, Hitomi Hoshi, Shingo Usui, Hirotoshi Ebinuma, Yuko Kitagawa, Hidetsugu Saito, Takanori Kanai
Publikováno v:
Hepatology Communications, Vol 4, Iss 7, Pp 1019-1033 (2020)
Controversies and debates remain regarding the best management of severe acute‐onset autoimmune hepatitis (SA‐AIH) due to the lack of useful outcome or complication prediction systems. We conducted this clinical practice‐based observational stu
Externí odkaz:
https://doaj.org/article/a0c8fc7f84f74ce0bdc36c7b28b06d3a
Autor:
Shunsuke Shiba, Po-sung Chu, Nobuhiro Nakamoto, Karin Yamataka, Nobuhito Taniki, Keisuke Ojiro, Akihiro Yamaguchi, Rei Morikawa, Aya Yoshida, Akihiko Ikura, Hirotoshi Ebinuma, Hidetsugu Saito, Takanori Kanai
Publikováno v:
BMC Gastroenterology, Vol 20, Iss 1, Pp 1-14 (2020)
Abstract Background Prognostic value or clinical implications of fluid status monitoring in liver cirrhosis are not fully elucidated. Tolvaptan, an orally available, selective vasopressin V2-receptor antagonist approved for hyponatremia in the United
Externí odkaz:
https://doaj.org/article/2792815d456e46feac8df17bd856af1d
Autor:
Tomoko Yamaguchi, Juntaro Matsuzaki, Takeshi Katsuda, Yoshimasa Saito, Hidetsugu Saito, Takahiro Ochiya
Publikováno v:
Inflammation and Regeneration, Vol 39, Iss 1, Pp 1-9 (2019)
Abstract Liver and hepatocyte transplantation are the only effective therapies for late-stage liver diseases, in which the liver loses its regenerative capacity. However, there is a shortage of donors. As a potential alternative approach, functional
Externí odkaz:
https://doaj.org/article/f16f4d757741449bb908da74b7206aae
Autor:
Ryoei Uchida, Yoshimasa Saito, Kazuki Nogami, Yohei Kajiyama, Yukana Suzuki, Yasuhiro Kawase, Toshiaki Nakaoka, Toshihide Muramatsu, Masaki Kimura, Hidetsugu Saito
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 4, Iss 1, Pp 1-9 (2018)
Epigenetic silencing of Lgr5 in aged organoids To understand the molecular features underlying stem cell aging, we established intestinal epithelial organoids derived from both young and aged mice, and investigated alterations in their senescence and
Externí odkaz:
https://doaj.org/article/e1c53da2776440f3a69b4e2f9cf4edf3
Autor:
Aya Ugamura, Po‐sung Chu, Nobuhiro Nakamoto, Nobuhito Taniki, Keisuke Ojiro, Taizo Hibi, Masahiro Shinoda, Hideaki Obara, Yohei Masugi, Akihiro Yamaguchi, Shunsuke Shiba, Rei Morikawa, Shingo Usui, Hirotoshi Ebinuma, Yuko Kitagawa, Hidetsugu Saito, Takanori Kanai
Publikováno v:
Hepatology Communications, Vol 2, Iss 11, Pp 1331-1343 (2018)
A prognostic system for acute liver failure (ALF) with a higher predictive value is urgently needed. The role of extracellular matrix (ECM) remodeling in ALF has not been fully elucidated. We hypothesized that serologic fibrosis markers, which reflec
Externí odkaz:
https://doaj.org/article/6e8544dc299648ffba38689f2e81365f
Autor:
Hitomi Hoshi, Po-Sung Chu, Aya Yoshida, Nobuhito Taniki, Rei Morikawa, Karin Yamataka, Fumie Noguchi, Ryosuke Kasuga, Takaya Tabuchi, Hirotoshi Ebinuma, Hidetsugu Saito, Takanori Kanai, Nobuhiro Nakamoto
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0250062 (2021)
BackgroundAcute decompensation (AD) of liver cirrhosis (LC) and subsequent acute-on-chronic liver failure (ACLF) are fatal and impair quality of life. Insufficient knowledge of the highly heterogeneous natural history of LC, including decompensation,
Externí odkaz:
https://doaj.org/article/2b60a05549f641af948301a009dc191b
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100009- (2020)
Summary: This protocol is a procedure for establishment and culture of cancer and non-cancer organoids using tissues from biliary tract carcinoma (BTC) patients. These BTC organoids can be used for various biological analyses and drug screening. One
Externí odkaz:
https://doaj.org/article/b5c49eb7bfae49059b6c44a372ebb3f0
Autor:
Yuko Murakami, Kazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Keisuke Ojiro, Po-sung Chu, Nobuhito Taniki, Yoshimasa Saito, Toshiaki Teratani, Yuzo Koda, Takahiro Suzuki, Kyoko Saito, Masayoshi Fukasawa, Masanori Ikeda, Nobuyuki Kato, Takanori Kanai, Hidetsugu Saito
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-14 (2018)
Abstract Background We previously showed that knockdown of nuclear factor E2-related factor 2 (Nrf2) resulted in suppression of hepatitis C virus (HCV) infection. In this study, whether brusatol, an Nrf2 inhibitor, has dual anti-HCV and anticancer ef
Externí odkaz:
https://doaj.org/article/d927885653d9472a9a1f17560ba29dc0
Autor:
Yoshimasa Saito, Toshiaki Nakaoka, Toshihide Muramatsu, Hidenori Ojima, Aoi Sukeda, Yuko Sugiyama, Ryoei Uchida, Ryo Furukawa, Aya Kitahara, Toshiro Sato, Yae Kanai, Hidetsugu Saito
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Intrahepatic cholangiocarcinoma (IHCC) is a highly aggressive malignancy with a poor prognosis. It is thought to originate from cholangiocytes, which are the component cells of intrahepatic bile ducts. However, as patients with viral hepatit
Externí odkaz:
https://doaj.org/article/f69bc81672bf4ab595b91a7b1a8952f1
Autor:
Shoji Yamada, Nobuhiko Kamada, Takeru Amiya, Nobuhiro Nakamoto, Toshiaki Nakaoka, Masaki Kimura, Yoshimasa Saito, Chieko Ejima, Takanori Kanai, Hidetsugu Saito
Publikováno v:
BMC Gastroenterology, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background The gut microbiota plays crucial roles in the development of non-alcoholic steatohepatitis (NASH). However, the precise mechanisms by which alterations of the gut microbiota and its metabolism contributing to the pathogenesis of N
Externí odkaz:
https://doaj.org/article/049991361f6f4406b260859888d8f024