Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Hidetsugu, Asada"'
Autor:
Dohyun Im, Mika Jormakka, Narinobu Juge, Jun-ichi Kishikawa, Takayuki Kato, Yukihiko Sugita, Takeshi Noda, Tomoko Uemura, Yuki Shiimura, Takaaki Miyaji, Hidetsugu Asada, So Iwata
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract Human vesicular monoamine transporter 2 (VMAT2), a member of the SLC18 family, plays a crucial role in regulating neurotransmitters in the brain by facilitating their uptake and storage within vesicles, preparing them for exocytotic release.
Externí odkaz:
https://doaj.org/article/c1f588dce25945ba8399b5c51bbbd82f
Autor:
Dohyun Im, Jun-ichi Kishikawa, Yuki Shiimura, Hiromi Hisano, Akane Ito, Yoko Fujita-Fujiharu, Yukihiko Sugita, Takeshi Noda, Takayuki Kato, Hidetsugu Asada, So Iwata
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Histamine is a biogenic amine that participates in allergic and inflammatory processes by stimulating histamine receptors. The histamine H4 receptor (H4R) is a potential therapeutic target for chronic inflammatory diseases such as asthma and
Externí odkaz:
https://doaj.org/article/aecb7ce92dad48079fb1d6b2c25e5659
Autor:
Dohyun Im, Asuka Inoue, Takaaki Fujiwara, Takanori Nakane, Yasuaki Yamanaka, Tomoko Uemura, Chihiro Mori, Yuki Shiimura, Kanako Terakado Kimura, Hidetsugu Asada, Norimichi Nomura, Tomoyuki Tanaka, Ayumi Yamashita, Eriko Nango, Kensuke Tono, Francois Marie Ngako Kadji, Junken Aoki, So Iwata, Tatsuro Shimamura
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
The dopamine D2 receptor (D2R) is a GPCR and an important drug target for schizophrenia treatment. Here, the authors present the crystal structure of human D2R in complex with the antipsychotic drug spiperone, which is of interest for designing antip
Externí odkaz:
https://doaj.org/article/238cb5436dc34fefbac7633410b31405
Autor:
Yuki Shiimura, Shoichiro Horita, Akie Hamamoto, Hidetsugu Asada, Kunio Hirata, Misuzu Tanaka, Kenji Mori, Tomoko Uemura, Takuya Kobayashi, So Iwata, Masayasu Kojima
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Ghrelin is a gastric peptide hormone with important physiological functions, including growth hormone release and appetite-stimulating activity. Here, authors solved the crystal structure of the ghrelin receptor bound to antagonist and suggested a po
Externí odkaz:
https://doaj.org/article/e7526d5cb5754366b7a2d14fcf34c3e1
Publikováno v:
Acta Crystallographica Section D Structural Biology. 79:435-441
Structure determination of G-protein-coupled receptors (GPCRs) is key for the successful development of efficient drugs targeting GPCRs. BRIL is a thermostabilized apocytochrome b 562 (with M7W/H102I/R106L mutations) from Escherichia coli and is ofte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23bc1fed0271d985cce35a45e96877fb
https://doi.org/10.1107/s205979832300311x
https://doi.org/10.1107/s205979832300311x
Autor:
Hidetsugu Asada, Dohyun Im, Yunhon Hotta, Satoshi Yasuda, Takeshi Murata, Ryoji Suno, So Iwata
Publikováno v:
Structure (London, England : 1993). 30(12)
Orexin receptors are a family of G protein-coupled receptors that consist of two subtypes: orexin-1 receptors (OX1Rs) and OX2Rs. They are expressed throughout the central nervous system and are involved in regulating the sleep-wake cycle. The develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a400250b6a2968a7f5d6ee32351e0af
https://pubmed.ncbi.nlm.nih.gov/36417909
https://pubmed.ncbi.nlm.nih.gov/36417909
Autor:
Tomoko Uemura, Takuya Kobayashi, Kenji Mori, Masayasu Kojima, So Iwata, Kunio Hirata, Shoichiro Horita, Akie Hamamoto, Misuzu Tanaka, Yuki Shiimura, Hidetsugu Asada
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Ghrelin is a gastric peptide hormone with important physiological functions. The unique feature of ghrelin is its Serine 3 acyl-modification, which is essential for ghrelin’s activity. However, it remains to be elucidated why the acyl-modification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f735a7667d72f015716a452c53811dc6
https://doaj.org/article/e7526d5cb5754366b7a2d14fcf34c3e1
https://doaj.org/article/e7526d5cb5754366b7a2d14fcf34c3e1
Autor:
Tatsuro Shimamura, So Iwata, Takatoshi Arakawa, Dohyun Im, Hidetsugu Asada, Kanako Terakado Kimura, Francois Marie Ngako Kadji, Kunio Hirata, Junken Aoki, Norimichi Nomura, Asuka Inoue, Yayoi Nomura, Chihiro Mori
Publikováno v:
Nature Structural & Molecular Biology. 26:121-128
Many drugs target the serotonin 2A receptor (5-HT2AR), including second-generation antipsychotics that also target the dopamine D2 receptor (D2R). These drugs often produce severe side effects due to non-selective binding to other aminergic receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a1fb1fbcbe2f222d4cf2c240384417a
https://doi.org/10.1038/s41594-018-0180-z
https://doi.org/10.1038/s41594-018-0180-z
Autor:
Hidetsugu Asada, Chihiro Mori, Tomoko Uemura, Ayumi Yamashita, Dohyun Im, Tatsuro Shimamura, Kanako Terakado Kimura, Norimichi Nomura, So Iwata, Eriko Nango, Yuki Shiimura, Asuka Inoue, Yasuaki Yamanaka, Takanori Nakane, Tomoyuki Tanaka, Francois Marie Ngako Kadji, Junken Aoki, Kensuke Tono, Takaaki Fujiwara
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
In addition to the serotonin 5-HT2A receptor (5-HT2AR), the dopamine D2 receptor (D2R) is a key therapeutic target of antipsychotics for the treatment of schizophrenia. The inactive state structures of D2R have been described in complex with the inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fedb9ef3ccbf8428ba01203451af44e
http://europepmc.org/articles/PMC7755896
http://europepmc.org/articles/PMC7755896
Autor:
Junken Aoki, Masatoshi Hagiwara, Asuka Inoue, Kunio Hirata, Yuki Shiimura, Shintaro Maeda, Eriko Nango, Masayasu Toyomoto, Nobuo Tanaka, Hidetsugu Asada, Fangjia Luo, So Iwata
Publikováno v:
Science Advances
Active S1PR3 structure reveals the unique ligand-binding mode and signaling selectivity switching mechanism.
Sphingosine-1-phosphate (S1P) regulates numerous important physiological functions, including immune response and vascular integrity, vi
Sphingosine-1-phosphate (S1P) regulates numerous important physiological functions, including immune response and vascular integrity, vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7488e5c612954f6b3f1e3ab9ceb9c31
https://pubmed.ncbi.nlm.nih.gov/34108205
https://pubmed.ncbi.nlm.nih.gov/34108205