Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hidetoshi Miyamoto"'
Autor:
Yuzo Koyama, Chihiro Sakumoto, Tokihiko Tamamizu, Yasuo Inoshita, Minoru Iwamoto, Takuya Kumamoto, Yoshinori Sato, Hideyoshi Tsuchiya, Hidetoshi Miyamoto
Publikováno v:
Organic Process Research & Development. 24:1294-1303
We describe the process research and development of a practical synthesis of glucokinase activator 1 as a potential drug for treating type 2 diabetes mellitus. The key structure, a 3,4-cis-difluori...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4abb40760c382bfee8a63e8acc718de7
https://doi.org/10.1021/acs.oprd.0c00180
https://doi.org/10.1021/acs.oprd.0c00180
Autor:
Narumi Hiramoto, Yukiko Maeda, Takahiro Itoh, Yoshiaki Kato, Hidetoshi Miyamoto, Eriko Takekoshi, Chihiro Sakumoto
Publikováno v:
Organic Process Research & Development. 19:1054-1061
A catalytic reaction is an important methodology for the production of pharmaceuticals from the viewpoint of green and sustainable chemistry. Since elemental impurity levels should be controlled within acceptable limits in API, the development of rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71da42bf01ec9b99ee8d0632873bde30
https://doi.org/10.1021/acs.oprd.5b00161
https://doi.org/10.1021/acs.oprd.5b00161
Autor:
Mitsuru Ueda, Shinji Ando, Teruaki Hayakawa, Hidetoshi Miyamoto, Akiike Toshiyuki, Masa-aki Kakimoto, Ziyi Ge, Toru Kajita
Publikováno v:
Adv. Funct. Mater.. 18:584-590
A new series of star-shaped bipolar host molecules, tris(4'-(1-phenyl-lH-benzimidazol-2-yl)biphen-yl-4-yl) amine (TIBN), tris(2'-methyl-4'-(l-phenyl-lH-benzimidazol-2-yl)biphenyl-4-yl)amine (Me-TIBN), and tris(2,2'-dimethyl-4'-( 1 -phenyl-1H-benzimid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f37feacdbd9728ce9049f653b3dce66
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100555978
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100555978
Publikováno v:
Tetrahedron Letters. 48:6868-6872
Construction of the taxane skeleton via the stereoselective conjugate addition of cyanide and the intramolecular B-alkyl Suzuki–Miyaura coupling reaction is described. A conjugate addition of cyanide to enone 17 proceeded diastereoselectively to pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb81cdb0aff5070e5aff930e7ec0833e
https://doi.org/10.1016/j.tetlet.2007.07.179
https://doi.org/10.1016/j.tetlet.2007.07.179
Autor:
Syuichi Wakabayashi, Kiyomi Ito, Hiroaki Suzaka, Kaori Ito, Hidetoshi Miyamoto, Hirotami Matsuo, Tatsuji Iga, Yasufumi Sawada
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 26:47-52
Angiotensin converting enzyme (ACE) inhibitor prevents the inactivation of bradykinin by inhibiting ACE activity, leading to side effects such as dry cough and angioedema. KD3-671 is a novel nonpeptide angiotensin II antagonist which is expected to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fced33a96d8b267be6a24d71ba13a2e1
https://doi.org/10.1007/bf03190375
https://doi.org/10.1007/bf03190375
Publikováno v:
Journal of the American Chemical Society. 119:3665-3669
It has been known that oxo amide crystals made up of achiral molecules can be photochemically converted into optically active β-lactams by irradiation with a high pressure mercury lamp. Although the oxo amide crystal belongs to an enantiomorphic cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9af962304ca2c9254139a8a0362b5d32
https://doi.org/10.1021/ja9620189
https://doi.org/10.1021/ja9620189
Publikováno v:
Biological and Pharmaceutical Bulletin. 19:384-387
We investigated the influence of the streptozocin (STZ)-diabetic state on the dose-response curves for salivary flow and protein content in saliva stimulated by pilocarpine and noradrenaline in mice. The diabetic state increased the relative weights
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa248276a586c2d33a11feef4d6f6d05
https://doi.org/10.1248/bpb.19.384
https://doi.org/10.1248/bpb.19.384
Publikováno v:
ChemInform. 28
It has been known that oxo amide crystals made up of achiral molecules can be photochemically converted into optically active β-lactams by irradiation with a high pressure mercury lamp. Although the oxo amide crystal belongs to an enantiomorphic cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::754081c9157a2aa35c37189b27f842aa
https://doi.org/10.1002/chin.199733112
https://doi.org/10.1002/chin.199733112
Publikováno v:
Journal of Molecular Structure. 220:251-260
The 13 C cross-polarization, magic-angle-spinning (CP-MAS) NMR spectra of poly ( l -phenylalanine) and oligopeptides containing a l -phenylalanine or l -tyrosine residue in the solid state have been measured, in order to elucidate the side-chain conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8937d27616e1c648d5d6ab2dcc25b0ba
https://doi.org/10.1016/0022-2860(90)80115-z
https://doi.org/10.1016/0022-2860(90)80115-z
Publikováno v:
ChemInform. 37
A new asymmetric total synthesis of (-)-malyngolide is described. This synthesis is based on the originally developed catalytic asymmetric IMCP reaction; that is, α-diazo-β-keto sulfone (13) was successfully converted to cyclopropane (12) in 92 % y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24ecfd3cf281a49546817751ff2aafc
https://doi.org/10.1002/chin.200622204
https://doi.org/10.1002/chin.200622204