Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hidetoshi Isawa"'
Autor:
Kyoko Nakagawa-Goto, Hidetoshi Isawa, Tetsuji Ozawa, Masahiro Kobayashi, Takehiro Ishikawa, Masayuki Nishimura, Norihiko Kikuchi, Ritsu Suzuki, Junichi Sonehara, Yohei Saito, Takayuki Ainai, Kiyoshi Kasai, Kobayashi Makoto
Publikováno v:
Organic Process Research & Development. 24:1675-1682
An efficient route for the multikilogram synthesis of a selective β3-adrenergic receptor agonist, ritobegron ethyl hydrochloride (1), was developed by changing the coupling method of 4-hydroxynorep...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0dafadea840aac24db40213f0c214e40
https://doi.org/10.1021/acs.oprd.0c00278
https://doi.org/10.1021/acs.oprd.0c00278
Publikováno v:
CHEMICAL & PHARMACEUTICAL BULLETIN. 64:1009-1018
A practical preparation of 4-(substituted benzyl)-3-(2,3,4,6-tetra-O-acyl-β-D-glucopyranosyloxy)-1H-pyrazole derivative 2 is described. O-Glycosylation of 4-(substituted benzyl)-1,2-dihydro-3H-pyrazol-3-one derivative 3 was facilitated by introducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e11bf24fe3cd98e06cc7b0abfe139bc3
https://doi.org/10.1248/cpb.c15-00982
https://doi.org/10.1248/cpb.c15-00982
Publikováno v:
Chemicalpharmaceutical bulletin. 64(7)
A practical preparation of 4-(substituted benzyl)-3-(2,3,4,6-tetra-O-acyl-β-D-glucopyranosyloxy)-1H-pyrazole derivative 2 is described. O-Glycosylation of 4-(substituted benzyl)-1,2-dihydro-3H-pyrazol-3-one derivative 3 was facilitated by introducti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9a2a2c1e2803a990b2af123dffa6f18d
https://pubmed.ncbi.nlm.nih.gov/27373664
https://pubmed.ncbi.nlm.nih.gov/27373664
Publikováno v:
HETEROCYCLES. 78(2):319-324
The reactions of potassium 1,3-bis(ethoxycarbonyl)indolizine-2-thiolates with ethyl 4-bromocrotonate afforded the corresponding indolizine derivatives having (E)-(3-ethoxycarbonyl-2-propenyl)thio, (E)- and (Z)-(3-ethoxycarbonyl-1-propenyl)thio group
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8946ab2b4ea43e30a8501449a51dcab8
https://soar-ir.repo.nii.ac.jp/records/12583
https://soar-ir.repo.nii.ac.jp/records/12583
Publikováno v:
HETEROCYCLES. 92:1599
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e7721ca2dc2177e400f5a98e226760e
https://doi.org/10.3987/com-16-13484
https://doi.org/10.3987/com-16-13484
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db34aa145e0b09bac4403d88b9828603
https://doi.org/10.1002/chin.199119186
https://doi.org/10.1002/chin.199119186
Publikováno v:
ChemInform. 40
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d3040080554479ab8ca895452c962d7
https://doi.org/10.1002/chin.200926186
https://doi.org/10.1002/chin.200926186
Autor:
Harunobu Mukaiyama, Hideyuki Muranaka, Hiroaki Kobayashi, Masahiko Uchida, Tomonaga Ozawa, Yasuoki Murakami, Kosuke Okazaki, Yuji Hoyano, Yuichiro Kai, Hiroaki Okuno, Norihiko Kikuchi, Kenji Yokoyama, Hiroaki Shiohara, Kiyoto Hara, Eiichi Tsuji, Takashi Koizumi, Hidetoshi Isawa, Hideki Takeuchi, Keiko Misawa, Shigeru Nakano
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(16)
A series of novel and potent 3-amidinophenylsulfonamide derivatives of factor Xa inhibitors were designed and synthesized using an amidoxime prodrug strategy. We focused on systemic clearance of parent compounds in rats, and performed in vivo pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886bf33ad748cc1add1bf5be3dafc9b0
https://pubmed.ncbi.nlm.nih.gov/18667303
https://pubmed.ncbi.nlm.nih.gov/18667303
Publikováno v:
Heterocyclic Communications. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ff744a04967606b5551aa00b1b6e1ba
https://doi.org/10.1515/hc.2008.14.3.141
https://doi.org/10.1515/hc.2008.14.3.141
Autor:
Tsuneaki Takashima, Akikazu Kakehi, Hidetoshi Isawa, Tosio Sakurai, Suketaka Ito, Kunio Urushido
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:2667-2675
Various 2-(acylmethylthio)-, 2-(benzylthio)-, and 2-(propargylthio)pyrazolo[1, 5-a]pyridine derivatives (4a-n' and 7a-n') were prepared in moderate to good yields by the reactions of potassium pyrazolo[1, 5-a]pyridine-2-thiolates (2 and 6), readily a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53f2f48cf3f8fbc234624847611c2453
https://doi.org/10.1248/cpb.38.2667
https://doi.org/10.1248/cpb.38.2667