Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Hideto Mori"'
Autor:
Toshihiro Nakane, Ryoya Nakagawa, Soh Ishiguro, Sae Okazaki, Hideto Mori, Yutaro Shuto, Keitaro Yamashita, Nozomu Yachie, Hiroshi Nishimasu, Osamu Nureki
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-10 (2024)
Abstract The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets complementary to an RNA guide, and is widely used as a powerful genome-editing tool. Here, we report the crystal structure of Brevibacillus laterosporus Cas9 (BlCas9, a
Externí odkaz:
https://doaj.org/article/783bfe326ea64e06babe63f8818ac743
Autor:
Manabu Ozawa, Hideto Mori, Tsutomu Endo, Yu Ishikawa-Yamauchi, Daisuke Motooka, Chihiro Emori, Masahiro Ikawa
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108456- (2023)
Summary: Male fertility decreases with aging, with spermatogenic decline being one of its causes. Altered testis environment is suggested as a cause of the phenotype; however, the associated mechanisms remain unclear. Herein, we investigated the age-
Externí odkaz:
https://doaj.org/article/fb2a7fd3eb684b9eb58f659567a5a555
Autor:
Hideto Mori, Nozomu Yachie
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
DNA constructs and their annotated sequence maps have been rapidly accumulating with the advancement of DNA cloning, synthesis, and assembly methods. Here the authors introduce QUEEN, a framework to describe and share DNA materials and construction p
Externí odkaz:
https://doaj.org/article/c3016ae808964d2aa604ac5c8319d0ce
Autor:
Ryoya Nakagawa, Soh Ishiguro, Sae Okazaki, Hideto Mori, Mamoru Tanaka, Hiroyuki Aburatani, Nozomu Yachie, Hiroshi Nishimasu, Osamu Nureki
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-8 (2022)
SpCas9 is a versatile genome-editing tool, but it is large and cannot be packaged efficiently in a AAV vector, limiting its application. The reported engineered Campylobacter jejuni Cas9 variant exhibits enhanced cleavage activity and a broader targe
Externí odkaz:
https://doaj.org/article/af853ca776f84a4fb19d26f881471e55
Autor:
Tsuyoshi Fukushima, Yosuke Tanaka, Keito Adachi, Nanami Masuyama, Akiho Tsuchiya, Shuhei Asada, Soh Ishiguro, Hideto Mori, Motoaki Seki, Nozomu Yachie, Susumu Goyama, Toshio Kitamura
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Cell behavior is controlled by complex gene regulatory networks. Although studies have uncovered diverse roles of individual genes, it has been challenging to record or control sequential genetic events in living cells. In this study, we des
Externí odkaz:
https://doaj.org/article/e60e48ea503548f2a78b8b97e2db5163
Autor:
Tadashi Yamamuro, Shuhei Nakamura, Yu Yamano, Tsutomu Endo, Kyosuke Yanagawa, Ayaka Tokumura, Takafumi Matsumura, Kiyonori Kobayashi, Hideto Mori, Yusuke Enokidani, Gota Yoshida, Hitomi Imoto, Tsuyoshi Kawabata, Maho Hamasaki, Akiko Kuma, Sohei Kuribayashi, Kentaro Takezawa, Yuki Okada, Manabu Ozawa, Shinichiro Fukuhara, Takashi Shinohara, Masahito Ikawa, Tamotsu Yoshimori
Publikováno v:
PLoS Genetics, Vol 17, Iss 8 (2021)
Autophagy degrades unnecessary proteins or damaged organelles to maintain cellular function. Therefore, autophagy has a preventive role against various diseases including hepatic disorders, neurodegenerative diseases, and cancer. Although autophagy i
Externí odkaz:
https://doaj.org/article/d2de1c9609cc4eabada556ef6ddc88f3
Autor:
Atsushi Ishihara, Hiroyuki Aga, Yasuko Ishihara, Hirotake Ichikawa, Hidetaka Kaji, Koichi Kawasaki, Daita Kobayashi, Toshimi Kobayashi, Ken Nishida, Takumi Hamasaki, Hideto Mori, Yuki Morikubo
Publikováno v:
IEEE Transactions on Visualization and Computer Graphics. 29:2826-2836
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af79ba63d22f3c81423238042d31059f
https://doi.org/10.1109/tvcg.2023.3247460
https://doi.org/10.1109/tvcg.2023.3247460
Autor:
Soh Ishiguro, Kana Ishida, Rina C. Sakata, Hideto Mori, Mamoru Takana, Samuel King, Omar Bashth, Minori Ichiraku, Nanami Masuyama, Ren Takimoto, Yusuke Kijima, Arman Adel, Hiromi Toyoshima, Motoaki Seki, Ju Hee Oh, Anne-Sophie Archambault, Keiji Nishida, Akihiko Kondo, Satoru Kuhara, Hiroyuki Aburatani, Ramon I. Klein Geltink, Yasuhiro Takashima, Nika Shakiba, Nozomu Yachie
Clonal heterogeneity underlies diverse biological processes, including cancer progression, cell differentiation, and microbial evolution. Cell tagging strategies with DNA barcodes have recently enabled analysis of clone size dynamics and clone-restri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::357f721bd143c6e9ba151267c322a171
https://doi.org/10.1101/2023.01.18.524633
https://doi.org/10.1101/2023.01.18.524633
Autor:
Naoki Konno, Yusuke Kijima, Keito Watano, Soh Ishiguro, Keiichiro Ono, Mamoru Tanaka, Hideto Mori, Nanami Masuyama, Dexter Pratt, Trey Ideker, Wataru Iwasaki, Nozomu Yachie
Publikováno v:
Nature biotechnology, vol 40, iss 4
Nat Biotechnol
Nat Biotechnol
Phylogeny estimation (the reconstruction of evolutionary trees) has recently been applied to CRISPR-based cell lineage tracing, allowing the developmental history of an individual tissue or organism to be inferred from a large number of mutated seque
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6bc85a0c87ed7693df2bd5e4742492b
https://escholarship.org/uc/item/49q2q9n7
https://escholarship.org/uc/item/49q2q9n7
Autor:
Kazuharu Arakawa, Hiroshi Nishimasu, Hiroki Ueda, Rina C. Sakata, Akihiko Kondo, Hideto Mori, Shogo Yamamoto, Motoaki Seki, Kenji Tatsuno, Soh Ishiguro, Masaru Tomita, Mamoru Tanaka, Keiji Nishida, Nanami Masuyama, Hiroyuki Aburatani, Nozomu Yachie, Osamu Nureki
Publikováno v:
Nature Biotechnology. 38:865-869
We describe base editors that combine both cytosine and adenine base-editing functions. A codon-optimized fusion of the cytosine deaminase PmCDA1, the adenosine deaminase TadA and a Cas9 nickase (Target-ACEmax) showed a high median simultaneous C-to-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c72f2fd67c36164a987e2b2d8175c411
https://doi.org/10.1038/s41587-020-0509-0
https://doi.org/10.1038/s41587-020-0509-0