Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hideto Hara"'
Autor:
Toshiyuki Nomura, Hiroshi Sugimoto, Noriko Uchiyama, Akihiro Ohashi, Hideto Hara, Takashi Imada, Yukiko Yamamoto, Isaac Hoffman, Kenichi Iwai, Momoko Ohori, Misaki Homma, Osamu Kurasawa, Nobuo Cho, Tohru Miyazaki, Yuya Oguro, Kentaro Iwata, Robert J. Skene
Publikováno v:
Journal of Medicinal Chemistry. 63:1084-1104
In our pursuit of developing a novel, potent, and selective cell division cycle 7 (Cdc7) inhibitor, we optimized the previously reported thieno[3,2-d]pyrimidinone analogue I showing time-dependent Cdc7 kinase inhibition and slow dissociation kinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::302cc8787b4b0af51ff2d819e10565ac
https://doi.org/10.1021/acs.jmedchem.9b01427
https://doi.org/10.1021/acs.jmedchem.9b01427
Autor:
Taisuke Katoh, Tomoya Sameshima, Masato Yoshikawa, Tomoya Yukawa, Hideto Hara, Takatoshi Yogo, Russell Naven, Makoto Miyamoto, Ikuo Miyahisa, Yoshihiko Hirozane, Teruaki Okuda
Publikováno v:
Chemical Research in Toxicology. 33:154-161
Despite the recent advances in the life sciences and the remarkable investment in drug discovery research, the success rate of small-molecule drug development remains low. Safety is the second most influential factor of drug attrition in clinical stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de95254694309472dcddfb7d08032ee3
https://doi.org/10.1021/acs.chemrestox.9b00128
https://doi.org/10.1021/acs.chemrestox.9b00128
Autor:
Osamu, Kurasawa, Tohru, Miyazaki, Misaki, Homma, Yuya, Oguro, Takashi, Imada, Noriko, Uchiyama, Kenichi, Iwai, Yukiko, Yamamoto, Momoko, Ohori, Hideto, Hara, Hiroshi, Sugimoto, Kentaro, Iwata, Robert, Skene, Isaac, Hoffman, Akihiro, Ohashi, Toshiyuki, Nomura, Nobuo, Cho
Publikováno v:
Journal of medicinal chemistry. 63(3)
In our pursuit of developing a novel, potent, and selective cell division cycle 7 (Cdc7) inhibitor, we optimized the previously reported thieno[3,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65206dbfb7f69de0b5181ef73a51d57d
https://pubmed.ncbi.nlm.nih.gov/31895562
https://pubmed.ncbi.nlm.nih.gov/31895562
Publikováno v:
IPSJ Transactions on Bioinformatics. 11:41-47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e95690dde551846f63e30d20d9caa062
https://doi.org/10.2197/ipsjtbio.11.41
https://doi.org/10.2197/ipsjtbio.11.41
Autor:
Hideto Hara, Misaki Homma, Akihiro Ohashi, Yuya Oguro, Kouji Mori, Osamu Kurasawa, Nobuo Cho, Tohru Miyazaki, Sei Yoshida, Kenichi Iwai, Noriko Uchiyama
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:3658-3670
In order to increase the success rate for developing new Cdc7 inhibitors for cancer therapy, we explored a new chemotype which can comply with the previously-constructed pharmacophore model. Substitution of a pyridine ring of a serendipitously-identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbf0cb711b3289b52763b9b0437e281f
https://doi.org/10.1016/j.bmc.2017.04.044
https://doi.org/10.1016/j.bmc.2017.04.044
Autor:
Isaac Hoffman, Sei Yoshida, Osamu Kurasawa, Kenichi Iwai, Tomoyasu Ishikawa, Kouji Mori, Akihiro Ohashi, Hideto Hara, Nobuo Cho, Tohru Miyazaki, Robert J. Skene, Yuya Oguro, Misaki Homma
Publikováno v:
Bioorganicmedicinal chemistry. 25(7)
Cell division cycle 7 (Cdc7) is a serine/threonine kinase that plays important roles in the regulation of DNA replication process. A genetic study indicates that Cdc7 inhibition can induce selective tumor-cell death in a p53-dependent manner, suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0f9a7ca7899e8598f82eecd7960b9a
https://pubmed.ncbi.nlm.nih.gov/28284870
https://pubmed.ncbi.nlm.nih.gov/28284870
Publikováno v:
Journal of Chemical Information and Modeling. 48:364-369
In the lead optimization process, medicinal chemists must consider various chemical properties of active compounds, including ADME/Tox properties, and find the best compromise among these. This study presents a novel data mining method for multiobjec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000b8a3543802e41860c5425aa970d22
https://doi.org/10.1021/ci700262y
https://doi.org/10.1021/ci700262y
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-8 (2021)
Abstract Background Socket fixation with bone grafting for dysplastic hips is technically demanding, and inadequate coverage of the socket may cause poor results in patients with severely dysplastic hips. An accurate technique to form a bone graft to
Externí odkaz:
https://doaj.org/article/374923f7fa3f438ab5aa870124b816a2
Publikováno v:
ChemInform. 39
In the lead optimization process, medicinal chemists must consider various chemical properties of active compounds, including ADME/Tox properties, and find the best compromise among these. This study presents a novel data mining method for multiobjec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfafd12b664ed0cfea5de670db776051
https://doi.org/10.1002/chin.200821216
https://doi.org/10.1002/chin.200821216
Publikováno v:
BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-7 (2021)
Abstract Background In our institute, all elderly patients with displaced femoral neck fracture were treated with cemented bipolar hemiarthroplasty (BHA) using the modified Dall approach. To our knowledge, there are no reports on the knot position of
Externí odkaz:
https://doaj.org/article/cf2d06828988446ba5c5ce3996969315