Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Hideto Amano"'
1
Akademický článek
QT PRODACT: A Multi-site Study of In Vitro Action Potential Assays on 21 Compounds in Isolated Guinea-Pig Papillary Muscles
Autor: Seiji Hayashi, Yoshihide Kii, Mitsuyasu Tabo, Hitoshi Fukuda, Tetsuji Itoh, Takashi Shimosato, Hideto Amano, Mamoru Saito, Hajime Morimoto, Kiyoshi Yamada, Atsuhiro Kanda, Toshimasa Ishitsuka, Takanobu Yamazaki, Yoichi Kiuchi, Shinya Taniguchi, Tatsuya Mori, Shigekazu Shimizu, Yuji Tsurubuchi, Shun-ichi Yasuda, Shin-ichi Kitani, Chiaki Shimada, Kazuo Kobayashi, Masaharu Komeno, Chieko Kasai, Toshiyasu Hombo, Keiji Yamamoto
Publikováno v: Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 423-437 (2005)
To construct a non-clinical database for drug-induced QT interval prolongation, the electrophysiological effects of 11 positive and 10 negative compounds on action potentials (AP) in guinea-pig papillary muscles were investigated in a multi-site stud
Externí odkaz: https://doaj.org/article/a0418258c79346d3ac043532653edbdc
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2
Akademický článek
QT PRODACT: Evaluation of the Potential of Compounds to Cause QT Interval Prolongation by Action Potential Assays Using Guinea-Pig Papillary Muscles
Autor: Yoshihide Kii, Seiji Hayashi, Mitsuyasu Tabo, Takashi Shimosato, Hitoshi Fukuda, Tetsuji Itoh, Hideto Amano, Mamoru Saito, Hajime Morimoto, Kiyoshi Yamada, Atsuhiro Kanda, Toshimasa Ishitsuka, Takanobu Yamazaki, Yoichi Kiuchi, Shinya Taniguchi, Tatsuya Mori, Shigekazu Shimizu, Yuji Tsurubuchi, Shun-ichi Yasuda, Shin-ichi Kitani, Chiaki Shimada, Kazuo Kobayashi, Masaharu Komeno, Chieko Kasai, Toshiyasu Hombo, Keiji Yamamoto
Publikováno v: Journal of Pharmacological Sciences, Vol 99, Iss 5, Pp 449-457 (2005)
Certain compounds that prolong QT interval in humans have little or no effect on action-potential (AP) duration used traditionally, but they inhibit rapidly-activated-delayed-rectifier potassium currents (IKr) and/or human ether-a-go-go-related gene
Externí odkaz: https://doaj.org/article/607f605ce3e84d8090d1635dfe43b73c
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4
Effect of Repeated Administration of KT3-671,a Nonpeptide AT1 Receptor Antagonist, on Diurnal Variation in Blood Pressure,Heart Rate,and Locomotor Activity in Stroke-Prone Spontaneously
Autor: Takeshi Suzuki, Kazuko Fujimoto, Seiichiro Mochizuki, Koichiro Kawashima, Takeshi Fujii, Hideto Amano, Akira Tomiyama
Publikováno v: Journal of Cardiovascular Pharmacology. 27:411-416
KT3-671, a nonpeptide AT1 receptor antagonist, was administered to 20-week-old stroke-prone spontaneously hypertensive rats (SHRSP) daily for 3 weeks. Its effects on systolic, mean, and diastolic arterial blood pressure (SAP, MAP, DAP), heart rate an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8ff6ed6647fb257db57b9a37d060f5c
https://doi.org/10.1097/00005344-199603000-00014
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5
Antihypertensive Effect of Chronic KT3-671, a Structurally New Nonpeptide Angiotensin AT1-Receptor Antagonist, in Stroke-Prone Spontaneously Hypertensive Rats
Autor: Seiichiro Mochizuki, Takeshi Fujii, Hideto Amano, Takeshi Suzuki, Koichiro Kawashima, Kazuko Fujimoto, Akira Tomiyama
Publikováno v: Japanese Journal of Pharmacology. 69:215-222
KT3-671 (2-propyl-8-oxo-1-[(2’-(1H-tetrazole-5-yl)biphenyl-4-yl)methyl]-4, 5, 6, 7-tetrahydrocycloheptimidazole), a structurally new nonpeptide angiotensin AT1-receptor antagonist, was administered orally and repeatedly to 15-week-old stroke-prone
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48f37ea8847afe9bf1aab2787e9a5782
https://doi.org/10.1254/jjp.69.215
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Plný text Recenzováno Digitální knihovna AV ČR
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