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of 78
pro vyhledávání: '"Hidetaka Yakura"'
Autor:
Hidetaka Yakura
Publikováno v:
Philosophies, Vol 5, Iss 4, Pp 38-0 (2020)
All living organisms are under stress imposed by their surrounding environments. They must adapt to their stressors to live and survive. At the forefront of this adaptation is a defense system called immunity. Immunity, as the most ancient cognitive
Externí odkaz:
https://doaj.org/article/76a756ced6324387b2e4f9267c1d2d04
Autor:
Hidetaka Yakura
Publikováno v:
Vaccines, Vol 8, Iss 3, p 541 (2020)
From the time of Thucydides in the 5th century BC, it has been known that specific recognition of pathogens and memory formation are critical components of immune functions. In contrast to the immune system of jawed vertebrates, such as humans and mi
Externí odkaz:
https://doaj.org/article/bb54d18f45f34f00835eff598cfedaaf
Autor:
Hidetaka Yakura
Publikováno v:
Adaptive Behavior. 27:167-173
Concerning what signifies the minimal requirements for a process to be designated cognitive, various criteria have been proposed, but the problem has not been settled. The important thing to consider in establishing the criteria is which criterion ha
Autor:
Hidetaka Yakura
This book explores the essence of immunity. After an initial review of hypotheses, models, and theories proposed to explain immune phenomena in humans and mice, it summarizes the results from synchronic organism‑level analyses and diachronic analys
Autor:
Hidetaka Yakura
Publikováno v:
Adaptive Behavior. 27:179-180
Autor:
M. Akimoto, K.-T. Lim, N. Tani, A. Elson, S.-i. Hisanaga, Tatsuo Katagiri, Hidetaka Yakura, Katsuya Mizuno, K. Mishra
Publikováno v:
Scandinavian Journal of Immunology. 69:401-411
Modulation of mast-cell activation may provide novel ways to control allergic diseases. Here, we show that protein tyrosine phosphatase epsilon (PTPepsilon; Ptpre) plays key regulatory roles during mast-cell activation mediated by the high-affinity I
Autor:
Chisei Ra, Kazuya Mizuno, Toshio Inoue, Hidetaka Yakura, Tetsuro Yoshimaru, Kazuko Nakata, Yoshihiro Suzuki
Publikováno v:
The Journal of Immunology. 181:5414-5424
Src homology region 2 domain-containing phosphatase 1 (SHP-1), a cytoplasmic protein tyrosine phosphatase, plays an important role for the regulation of signaling from various hematopoietic cell receptors. Although SHP-1 is shown to be a negative sig
Publikováno v:
International Immunology. 19:1049-1061
Src homology region 2-domain-containing phosphatase-1 (SHP-1) plays an important role in the regulation of signaling from various receptors in hematopoietic cells. In mast cells, SHP-1 has been shown to negatively regulate the initial signaling trigg
Publikováno v:
Blood. 103:1425-1432
CD45 is a key protein tyrosine phosphatase regulating Src-family protein tyrosine kinases (Src-PTKs) in lymphocytes; precisely how it exerts its effect remains controversial, however. We previously demonstrated that CD45 negatively regulates Lyn in t
Autor:
Katsuyuki Mitomo, Yuko Tagawa, Hidetaka Yakura, Tatsuo Katagiri, Mami Ogimoto, Noriyuki Watanabe, Kazuya Mizuno
Publikováno v:
The Journal of Immunology. 169:778-786
Src homology region 2 domain-containing phosphatase 1 (SHP-1) is a key mediator in lymphocyte differentiation, proliferation, and activation. We previously showed that B cell linker protein (BLNK) is a physiological substrate of SHP-1 and that B cell