Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Hidetaka Ohnuki"'
Autor:
Taekyu Ha, Michael DiPrima, Vishal Koparde, Parthav Jailwala, Hidetaka Ohnuki, Jing-Xin Feng, Murali Palangat, Daniel Larson, Giovanna Tosato
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 28, Iss , Pp 877-891 (2022)
Advances in gene therapy research have resulted in the successful development of new therapies for clinical use. Here, we explored a gene targeting approach to deplete ephrinB2 from colorectal cancer cells using an inducible lentiviral vector. Ephrin
Externí odkaz:
https://doaj.org/article/2dbdf16db27e41c0b007897ffdd92a3a
Autor:
Yuyi Wang, Ombretta Salvucci, Hidetaka Ohnuki, Andy D Tran, Taekyu Ha, Jing‐Xin Feng, Michael DiPrima, Hyeongil Kwak, Dunrui Wang, Yanlin Yu, Michael Kruhlak, Giovanna Tosato
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-21 (2021)
Abstract The tyrosine phosphatase SHP2 is oncogenic in cancers driven by receptor‐tyrosine‐kinases, and SHP2 inhibition reduces tumor growth. Here, we report that SHP2 is an essential promoter of endothelial cell survival and growth in the remode
Externí odkaz:
https://doaj.org/article/18628d9234a14174a940d08372600b84
Publikováno v:
Cells, Vol 9, Iss 7, p 1583 (2020)
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has resulted in >500,000 deaths worldwide, including >125,000 deaths in the U.S. since its emergence in late De
Externí odkaz:
https://doaj.org/article/bc79ccb133db4abaa32802779d974bce
Autor:
Hironao Nakayama, Hidetaka Ohnuki, Masako Nakahara, Hisayo Nishida-Fukuda, Tomohisa Sakaue, Shinji Fukuda, Shigeki Higashiyama, Yuki Doi, Masahiro Mitsuyoshi, Takashi Okimoto, Giovanna Tosato, Chiaki Kusumoto
Publikováno v:
Biochem Biophys Res Commun
Netrin-1, the protein product of the NTN1 gene, is an axon guidance molecule implicated in regulation of cell survival and tumorigenesis. Expression of the netrin-1 receptors deleted in colorectal cancer (DCC) and uncoordinated 5 homolog (UNC5H) is f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd7e6051cd57ececb4900d06eb81d18
https://doi.org/10.1016/j.bbrc.2022.04.069
https://doi.org/10.1016/j.bbrc.2022.04.069
Autor:
Giovanna Tosato, Dragan Maric, David Sánchez-Martín, Hyeongil Kwak, Ombretta Salvucci, Dunrui Wang, Kan Jiang, Hidetaka Ohnuki
PDF file - 1522KB, Supplementary Figure S1: shows the kinetics of EL4, LLC1 and B16F10 tumor growth in WT and Gfi1-KO mice. Supplemental Figure S2: analysis of EL4 and LLC1 tumor vascularization (A); distribution and typical profiles of CD11b+Ly6C+Ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::636e28a530fef2e77ea6d0171b86221c
https://doi.org/10.1158/0008-5472.22401303
https://doi.org/10.1158/0008-5472.22401303
Autor:
Giovanna Tosato, Dragan Maric, David Sánchez-Martín, Hyeongil Kwak, Ombretta Salvucci, Dunrui Wang, Kan Jiang, Hidetaka Ohnuki
Myeloid cells that orchestrate malignant progression in the tumor microenvironment offer targets for a generalized strategy to attack solid tumors. Through an analysis of tumor microenvironments, we explored an experimental model of lung cancer that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d861aa96bd18a466617c5326df26d7c
https://doi.org/10.1158/0008-5472.c.6505812
https://doi.org/10.1158/0008-5472.c.6505812
Publikováno v:
Journal of cancer metastasis and treatment
Genetic and epigenetic lesions within hematopoietic cell populations drive diverse hematological malignancies. Myelodysplastic syndromes (MDS) are a group of myeloid neoplasms affecting the hematopoietic stem cells characterized by recurrent genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b344a9e5c5b5dba8abdbff16a7e688c
https://doi.org/10.20517/2394-4722.2021.120
https://doi.org/10.20517/2394-4722.2021.120
Autor:
Jingxin Feng, Yuyi Wang, Andy D. Tran, Diprima Michael J, Taekyu Ha, Giovanna Tosato, Hidetaka Ohnuki, Hyeongil Kwak, Ombretta Salvucci, Dunrui Wang, Michael J. Kruhlak
The tyrosine phosphatase SHP2 is oncogenic in cancers driven by receptor-tyrosine-kinases, and SHP2 inhibition reduces tumor growth. Here, we report that SHP2 is an essential promoter of endothelial cell survival and growth in the remodeling tumor va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12ee87ddb43d837b5c2f7f403c4855e4
https://doi.org/10.1101/2020.10.06.327882
https://doi.org/10.1101/2020.10.06.327882
Gene expression in individual cells is epigenetically regulated by DNA modifications, histone modifications, transcription factors, and other DNA-binding proteins. It has been shown that multiple histone modifications can predict gene expression and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c69450bfb4ead86cde35ae4380d6085
https://doi.org/10.1101/2020.07.20.212969
https://doi.org/10.1101/2020.07.20.212969
Autor:
Hidetaka Ohnuki, Karen Aleman, Robert Yarchoan, Vickie Marshall, Thomas S. Uldrick, Mark N. Polizzotto, Denise Whitby, Hyeongil Kwak, Mark Raffeld, Christina M. Annunziata, David Sánchez-Martín, Victoria Wang, Giovanna Tosato, Kathleen M. Wyvill
Publikováno v:
JNCI: Journal of the National Cancer Institute. 109
Background Primary effusion lymphoma (PEL) is a Kaposi's sarcoma herpes virus (KSHV)-induced lymphoma that typically arises in body cavities of HIV-infected patients. PEL cells are often co-infected with Epstein-Barr virus (EBV). "PEL-like" lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb5d311b14962aa4aa452448018f946
https://doi.org/10.1093/jnci/djx016
https://doi.org/10.1093/jnci/djx016