Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Hidetaka, Morinaga"'
Autor:
Chisayo Kozuka, Chigusa Shimizu-Okabe, Chitoshi Takayama, Kaku Nakano, Hidetaka Morinaga, Ayano Kinjo, Kotaro Fukuda, Asuka Kamei, Akihito Yasuoka, Takashi Kondo, Keiko Abe, Kensuke Egashira, Hiroaki Masuzaki
Publikováno v:
Drug Delivery, Vol 24, Iss 1, Pp 558-568 (2017)
Our previous works demonstrated that brown rice-specific bioactive substance, γ-oryzanol acts as a chaperone, attenuates exaggerated endoplasmic reticulum (ER) stress in brain hypothalamus and pancreatic islets, thereby ameliorating metabolic derang
Externí odkaz:
https://doaj.org/article/8b4813d137704330bf54da9b7008609d
Autor:
Makito Tanabe, Toshihiko Yanase, Yuriko Hamaguchi, Tomoko Tanaka, Yoshimi Muta, Hidetaka Morinaga
Publikováno v:
Biochemical and Biophysical Research Communications. 557:97-103
Understanding of the mechanism of adipogenesis is essential for the control of obesity, which predisposes toward numerous health problems. High-mobility group box protein 2 (HMGB2) is a non-histone chromosomal protein that facilitates DNA replication
Autor:
Martin Lotz, Etsuo Chosa, Katsuaki Sato, Noboru Taniguchi, Deokcheol Lee, Hiroaki Kataoka, Hidetaka Morinaga, Narantsog Choijookhuu, Yoshitaka Hishikawa
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Autor:
Hidetaka Morinaga, Masakazu Fujii, Kathy Griendling, Yoshihiro Ogawa, Misato Okamoto, Noriyuki Sonoda
Publikováno v:
Diabetes. 67
Objectives: Polymerase delta interacting protein 2 (Poldip2) has previously been implicated in migration, proliferation and extracellular matrix (ECM) production in vascular smooth muscle cells. Thereby, regulation of Poldip2 protein expression is su
Autor:
Etsuo Chosa, Noboru Taniguchi, Hidetaka Morinaga, Katsuaki Sato, Hiroaki Kataoka, Yoshitaka Hishikawa, Deokcheol Lee, Narantsog Choijookhuu, Martin Lotz
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Although various surgical procedures have been developed for chronic rotator cuff tear repair, the re-tear rate remains high with severe fat infiltration. However, little is known about the molecular regulation of this process. Mesenchymal stem cells
Autor:
Kazuki Nabeshima, Takashi Nomiyama, Tomoko Tanaka, Takako Kawanami, Shinichiro Irie, Yuichi Terawaki, Kunitaka Murase, Masatoshi Tanaka, Yoko Tsutsumi, Ryoko Nagaishi, Makito Tanabe, Hidetaka Morinaga, Makio Mizoguchi, Yuriko Hamaguchi, Toshihiko Yanase
Publikováno v:
Diabetes. 63:3891-3905
Recently, pleiotropic benefits of incretin therapy beyond glycemic control have been reported. Although cancer is one of the main causes of death in diabetic patients, few reports describe the anticancer effects of incretin. Here, we examined the eff
Autor:
Ai Chen, Manuel Sanchez-Alavez, Jianfeng Xu, Kevin Dines, Saswata Talukdar, Gautam Bandyopadhyay, Michael W. Schwartz, Min Lu, David A. Sarruf, Pingping Li, Olivia Osborn, Steven M. Watkins, Jerrold M. Olefsky, Karl J. Kaiyala, Hidetaka Morinaga
Publikováno v:
Journal of Biological Chemistry. 288:10722-10735
Sirt1 is a NAD(+)-dependent class III deacetylase that functions as a cellular energy sensor. In addition to its well-characterized effects in peripheral tissues, emerging evidence suggests that neuronal Sirt1 activity plays a role in the central reg
Autor:
Jianfeng, Xu, Hidetaka, Morinaga, Dayoung, Oh, Pingping, Li, Ai, Chen, Saswata, Talukdar, Yaël, Mamane, Joseph A, Mancini, Andrea R, Nawrocki, Eduardo, Lazarowski, Jerrold M, Olefsky, Jane J, Kim
Publikováno v:
The Journal of Immunology. 189:1992-1999
GPR105, a G protein-coupled receptor for UDP-glucose, is highly expressed in several human tissues and participates in the innate immune response. Because inflammation has been implicated as a key initial trigger for type 2 diabetes, we hypothesized
Autor:
Hidetaka Morinaga, Tomoe Y. Nakamura, Takeshi Hashimoto, Nobuteru Usuda, Kinya Otsu, Tomohiro Yamaguchi, Kenta Kuramoto, Fumie Sakai, Masatoshi Nomura, Shigenobu Matsumura, Shigeo Wakabayashi, Kazuo Inoue, Yumiko Kojima, Fumiko Hirose, Takashi Osumi, Tohru Fushiki, Toshihiko Yanase, Tomo-o Okamura
Publikováno v:
Journal of Biological Chemistry. 287:23852-23863
Lipid droplets (LDs) are ubiquitous organelles storing neutral lipids, including triacylglycerol (TAG) and cholesterol ester. The properties of LDs vary greatly among tissues, and LD-binding proteins, the perilipin family in particular, play critical
Publikováno v:
Diabetes
Macrophage-mediated inflammation is a key component of insulin resistance; however, the initial events of monocyte migration to become tissue macrophages remain poorly understood. We report a new method to quantitate in vivo macrophage tracking (i.e.