Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hideo Tomozane"'
Autor:
Harutoshi Kato, Hiroshi Ikegami, Daisuke Abe, Makoto Sakiyama, Tadashi Mishina, Yumiko Iwase, Hideo Tomozane, Hideo Nakamura, Masayuki Hayashi, Masahiko Morioka, Yasuhiro Fujino, Shinsuke Ooike, Ryoichi Ando
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4709-4711
A new class of Aurora A kinase inhibitor was created by transforming 4-(5-methyl-3-pyrazoloamino)pyrimidine moiety of VX-680 to 3-cyano-6-(5-methyl-3pyrazoloamino)pyridine. Compound 6 exhibited a potent Aurora A kinase inhibitory activity, excellent
Autor:
Katsuhiko Itoh, Keiichiro Haga, Shuji Sonda, Masatake Fujimura, Takeshi Kawakita, Kiyoshi Asano, Noriko Sato, Hidetoshi Hakira, Hideo Tomozane
Publikováno v:
European Journal of Medicinal Chemistry. 34:1101-1108
Aseries of 4-amino-5-chloro-2-methoxy-N-(1-substituted piperidin-4-ylmethyl)benzamides was synthesized as novel gastroprokinetic agents. The affinity of these compounds for the 5-hydroxytryptamine 4 (5-HT4) receptor was evaluated. Among these compoun
Autor:
Takeshi Kawakita, Shuji Sonda, Koji Kanzaki, Keiichiro Haga, Takanobu Kuroita, Katsuhiko Itoh, Noriko Sato, Hideo Tomozane, Tsuguo Ikebe
Publikováno v:
European Journal of Medicinal Chemistry. 34:977-989
A number of new carboxamide derivatives were synthesized. The affinity of these compounds for the serotoninergic 5-HT(4) receptor was evaluated by use of radioligand-binding techniques. The agonistic activity was evaluated as the contractile effect o
Publikováno v:
ChemInform. 22
The Wittig reaction of benzofuran-2, 3-diones (2), cyclic α-ketoesters, was examined. The reaction of 2 having an electron-donating substituent on the aromatic ring with a stable ylide afforded not 3-alkylidene-2(3H)-benzofuranones (4) but 2-alkylid
Autor:
Masatake Fujimura, Shuji Sonda, Noriko Sato, Keiichiro Haga, Kiyoshi Asano, Hidetoshi Hakira, Hideo Tomozane, Takeshi Kawakita, Katsuhiko Itoh
Publikováno v:
ChemInform. 31
Aseries of 4-amino-5-chloro-2-methoxy-N-(1-substituted piperidin-4-ylmethyl)benzamides was synthesized as novel gastroprokinetic agents. The affinity of these compounds for the 5-hydroxytryptamine 4 (5-HT4) receptor was evaluated. Among these compoun
Autor:
Jiro Katayama, Takanobu Kuroita, Yoshifumi Togo, Yasunori Morio, Hideo Tomozane, Yasuhiro Matsumoto, Masakazu Fujio
Publikováno v:
ChemInform. 31
Autor:
Yoshifumi Togo, Masakazu Fujio, Yasunori Morio, Yasuhiro Matsumoto, Takanobu Kuroita, Hideo Tomozane, Jiro Katayama
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(5)
A series of benzamides was synthesized as selective agonists for the 5-HT1A receptor. It was found that (S)-N-[[1-(2-phenylethyl)pyrrolidin-2-yl]methyl]cyclohexanecarb oxamide(7-(S)) has potent and selective agonistic activity for the 5-HT1A receptor
Publikováno v:
Chemical and Pharmaceutical Bulletin. 38:2265-2267
The Wittig reaction of benzofuran-2, 3-diones (2), cyclic α-ketoesters, was examined. The reaction of 2 having an electron-donating substituent on the aromatic ring with a stable ylide afforded not 3-alkylidene-2(3H)-benzofuranones (4) but 2-alkylid
Autor:
Yasuo TAKEUCHI, Hideo TOMOZANE, Keiji MISUMI, Kuniko YATA, Teruyuki KAWATA, Yoshiko NIINO, Masatoshi YAMATO, Takashi HARAYAMA
Publikováno v:
Chemicalpharmaceutical bulletin. 45(2)
Griseofulvin derivatives, dl-6'-demethyl-6'-ethylgriseofulvin (dl-5) and dl-6'demethyl-6'phenylgriseofulvin (dl-6) were prepared by application of a synthetic method developed by us. Antifungal activity of these derivatives decreased in the order of
Publikováno v:
Chemicalpharmaceutical bulletin. 38(4)
dl-Griseofulvin (1a) was prepared by two synthetic pathways. New 6'-congeners (3 and 4) of griseofulvin were also prepared. Their antifungal activities were evaluated and compounds 3 and 4 were found to be less active than 1a. Molecular calculations