Výsledky vyhledávání - "Hideo Takashina"

Effects of functional groups of acrylic acid derivatives as derivatization reagents for thiol compounds on molecular ion responses in electrospray ionization-mass spectrometry

Autor: Hideo Takashina, Kenji Matsuura

Publikováno v: Journal of Mass Spectrometry. 33:1199-1208

In order to explore the sensitivity enhancement of derivatization reagents for thiol compounds with respect to liquid chromatography-mass spectrometry (LC-MS) analysis, the electrospray ionization (ESI)-MS of tiopronin (TP) derivatives (TP-MA, TP-IBA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::355fb3f1b4630ec26b19dca140760f5a
https://doi.org/10.1002/(sici)1096-9888(199812)33:12<1199::aid-jms736>3.0.co

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Enantioselective immunoaffinity extraction for simultaneous determination of optically active bufuralol and its metabolites in human plasma by HPLC

Autor: Ni Made Ria Isriyanthi, Youichi Kawashima, Kenji Matsuura, Takehiro Sato, Junichi Goto, Shinichi Miyairi, Hideo Takashina, Shigeo Ikegawa, Toshifumi Niwa

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 17:1-9

A combined method of immunoaffinity extraction with high-performance liquid chromatography has been developed for the enantioselective determination of bufuralol and its metabolites in human plasma. The antibodies having high affinity toward the asym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3bb5c465fbfd4178364877896a24973
https://doi.org/10.1016/s0731-7085(97)00147-7

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Beta adrenergic antagonist permeation across cultured rabbit corneal epithelial cells grown on permeable supports

Autor: Hideo Takashina, Atsutoshi Ota, Kouichi Kawazu, Hiromistu Shiono, Hidetoshi Tanioka, Toshimi Ikuse, Yoichi Kawashima

Publikováno v: Current Eye Research. 17:125-131

To determine whether cultured rabbit corneal epithelial cells (RCEC), grown on permeable supports, provide a suitable in vivo model for characterizing transcellular drug permeation and metabolism.Primary rabbit corneal epithelial cells grown in DMEM-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::973fcd1a0ebba44b61f9b5135cb79676
https://doi.org/10.1076/ceyr.17.2.125.5598

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Pharmacokinetics of Levofloxacin, a New Fluoroquinolone Agents, after Instillation of 0.5% 14C-levofloxacin Ophthalmic Solution to Pigmented Rats

Autor: Koji Oka, Yoichi Kawashima, Hajime Ibuki, Hideo Takashina, Tomoyuki Okamoto, Atsutoshi Ota

Publikováno v: Drug Metabolism and Pharmacokinetics. 12:281-288

The pharmacokinetics of levofloxacin (LVFX) was investigated after a single or repeated topical application of 0.5% 14C-LVFX ophthalmic solution to pigmented rats. In the case of repeated application, the ophthalmic solution was instilled 3 times a d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8fb8d2a9f6ba37e034246c83828fdfb
https://doi.org/10.2133/dmpk.12.281

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Determination of pilocarpine in aqueous humour by liquid chromatography—atmospheric pressure chemical ionization mass spectrometry

Autor: Hideo Takashina, Mituaki Kuwano, Kenji Matsuura

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 621:173-180

A new method has been developed for rapid analysis and determination of pilocarpine in aqueous humour using liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. The chromatography was carried out on a reversed-phase pheny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23a5858ab91a2702f5a681943a621d3
https://doi.org/10.1016/0378-4347(93)80093-j

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Gas chromatographic—mass spectrometric determination of tiopronin in human blood using acrylic acid esters as a derivatization reagent for the thiol group

Autor: Hideo Takashina, Kenji Matsuura

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 616:229-234

A gas chromatographic-mass spectrometric method for determining tiopronin, which has a thiol group, in human blood has been described. To prevent the oxidative degradation of tiopronin in the blood, its thiol group was immediately protected by treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbe4f410224511d98f03cb7d9bbf63a
https://doi.org/10.1016/0378-4347(93)80390-p

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Studies on the Metabolic Fate of Semotiadil Fumarate (SD-3211) I: Absorption, Distribution, Metabolism and Excretion after Single Administration to Male Rats

Autor: Nobuo Morikawa, Hidehito Matsuoka, Hajime Ibuki, Masato Horiuchi, Hidefumi Yamaguchi, Hideo Takashina, Syogo Miyagi

Publikováno v: Drug Metabolism and Pharmacokinetics. 7:315-330

The absorption, distribution, metabolism and excretion of 14C-semotiadil fumarate (14C-SD3211) were studied in rats after oral (dose ; 10mg/kg) or intravenous (1 mg/kg) single administration. 1. Concentration of radioactivity in the plasma reached th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6cc7b27101723971b97007e3d9d3a80
https://doi.org/10.2133/dmpk.7.315

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Comparative assessment of ocular tissue distribution of drug-related radioactivity after chronic oral administration of 14C-levofloxacin and 14C-chloroquine in pigmented rats

Autor: Shuichiro Tsutsumi, Hideo Takashina, Makoto Tanaka

Publikováno v: The Journal of pharmacy and pharmacology. 56(8)

Fluoroquinolones have been reported to have a high affinity for melanin. The ocular tissue distribution and accumulation of radioactivity was compared after repeated oral administration of 14C-levofloxacin and 14C-chloroquine at daily doses of 20 mg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad1e4b0ef18cd502669627c8664dbf7
https://pubmed.ncbi.nlm.nih.gov/15285841

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