Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Hideo Shindou"'
The role of lysophosphatidylcholine acyltransferase 2 in osteoblastic differentiation of C2C12 cells
Autor:
Shirou Tabe, Hisako Hikiji, Tomomi Hashidate‐Yoshida, Hideo Shindou, Takao Shimizu, Kazuhiro Tominaga
Publikováno v:
FEBS Open Bio, Vol 14, Iss 9, Pp 1490-1502 (2024)
Glycerophospholipids, a primary component of cellular membranes, play important structural and functional roles in cells. In the remodelling pathway (Lands' cycle), the concerted actions of phospholipase As and lysophospholipid acyltransferases (LPLA
Externí odkaz:
https://doaj.org/article/4fb2163549ec45c59df8158b2051d795
Autor:
Shuto Tanaka, Masataka Kawakita, Hikaru Yasui, Koichi Sudo, Fumie Itoh, Masato Sasaki, Nobuyuki Shibata, Hiromitsu Hara, Yoichiro Iwakura, Tomomi Hashidate-Yoshida, Hideo Shindou, Takao Shimizu, Taiki Oyama, Himawari Matsunaga, Kazuhiko Takahara
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-8 (2024)
Abstract Acute immune responses with excess production of cytokines, lipid/chemical mediators, or coagulation factors, often result in lethal damage. In addition, the innate immune system utilizes multiple types of receptors that recognize neurotrans
Externí odkaz:
https://doaj.org/article/1ce32dd6b57e4157970de60655be50fa
Sphingosine-1-phosphate promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis.
Autor:
Yosuke Osawa, Hironari Kawai, Keigo Nakashima, Yuichi Nakaseko, Daisuke Suto, Keisuke Yanagida, Tomomi Hashidate-Yoshida, Taizo Mori, Sachiyo Yoshio, Takaaki Ohtake, Hideo Shindou, Tatsuya Kanto
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0303296 (2024)
AimMetabolic dysfunction-associated steatohepatitis (MASH) is one of the most prevalent liver diseases and is characterized by steatosis and the accumulation of bioactive lipids. This study aims to understand the specific lipid species responsible fo
Externí odkaz:
https://doaj.org/article/a39a40adb53b45e78a3e925d9fbcd021
Autor:
Toshiya Matsukawa, Takashi Yagi, Tohru Uchida, Mashito Sakai, Masaru Mitsushima, Takao Naganuma, Hiroyuki Yano, Yuka Inaba, Hiroshi Inoue, Keisuke Yanagida, Masaaki Uematsu, Kazuki Nakao, Harumi Nakao, Atsu Aiba, Yoji Nagashima, Tetsuya Kubota, Naoto Kubota, Yoshihiko Izumida, Naoya Yahagi, Hiroyuki Unoki-Kubota, Yasushi Kaburagi, Shun-ichiro Asahara, Yoshiaki Kido, Hideo Shindou, Michiko Itoh, Yoshihiro Ogawa, Shiro Minami, Yasuo Terauchi, Kazuyuki Tobe, Kohjiro Ueki, Masato Kasuga, Michihiro Matsumoto
Publikováno v:
JCI Insight, Vol 8, Iss 17 (2023)
Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes are interacting comorbidities of obesity, and increased hepatic de novo lipogenesis (DNL), driven by hyperinsulinemia and carbohydrate overload, contributes to their pathogenesis. Fatty aci
Externí odkaz:
https://doaj.org/article/e5ab1c9c4a954f56823c71beefd37326
Autor:
Hiroki Kawana, Masaya Ozawa, Takeaki Shibata, Hirofumi Onishi, Yukitaka Sato, Kuniyuki Kano, Hideo Shindou, Takao Shimizu, Nozomu Kono, Junken Aoki
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 10, Pp 100271- (2022)
The main fatty acids at the sn-1 position of phospholipids (PLs) are saturated or monounsaturated fatty acids such as palmitic acid (C16:0), stearic acid (C18:0), and oleic acid (C18:1) and are constantly replaced, like unsaturated fatty acids at the
Externí odkaz:
https://doaj.org/article/da1169dbe34f4f01a7fb010653c09042
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Peripheral nerve injury (PNI) induces neuronal hyperexcitability, which underlies neuropathic pain. The emergence of RNA sequencing technologies has enabled profiling of transcriptional changes in pathological conditions. However, these approaches do
Externí odkaz:
https://doaj.org/article/576e878e97854bf58c925925e96aaf3c
Autor:
William J. Valentine, Sherif A. Mostafa, Suzumi M. Tokuoka, Fumie Hamano, Natsuko F. Inagaki, Joel Z. Nordin, Norio Motohashi, Yoshihiro Kita, Yoshitsugu Aoki, Takao Shimizu, Hideo Shindou
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
In Duchenne muscular dystrophy (DMD), lack of dystrophin increases the permeability of myofiber plasma membranes to ions and larger macromolecules, disrupting calcium signaling and leading to progressive muscle wasting. Although the biological origin
Externí odkaz:
https://doaj.org/article/dffd91e077b74473be10610053a34c06
Autor:
Azusa Kobayashi, Ayaka Ito, Ibuki Shirakawa, Atsushi Tamura, Susumu Tomono, Hideo Shindou, Per Niklas Hedde, Miyako Tanaka, Naotake Tsuboi, Takuji Ishimoto, Sachiko Akashi-Takamura, Shoichi Maruyama, Takayoshi Suganami
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Accumulating evidence suggests that cholesterol accumulation in leukocytes is causally associated with the development of autoimmune diseases. However, the mechanism by which fatty acid composition influences autoimmune responses remains unclear. To
Externí odkaz:
https://doaj.org/article/15704b94f80744bbb9fe0cc111083c27
Autor:
Nanami Senoo, Takumi Akahori, Hiyori Ichida, Noriyuki Miyoshi, Akihito Morita, Takao Shimizu, Hideo Shindou, Shinji Miura
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0255178 (2021)
Fasting stimulates catabolic reactions in skeletal muscle to survive nutrient deprivation. Cellular phospholipids have large structural diversity due to various polar-heads and acyl-chains that affect many cellular functions. Skeletal muscle phosphol
Externí odkaz:
https://doaj.org/article/845530924edd4563a7cda8cca13ebdf0
Autor:
Daisuke Hishikawa, Keisuke Yanagida, Katsuyuki Nagata, Ayumi Kanatani, Yoshiko Iizuka, Fumie Hamano, Megumi Yasuda, Tadashi Okamura, Hideo Shindou, Takao Shimizu
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101495- (2020)
Summary: Polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid (DHA) and arachidonic acid (ARA), play fundamental roles in mammalian physiology. Although PUFA imbalance causes various disorders, mechanisms of the regulation of their syste
Externí odkaz:
https://doaj.org/article/024f480d745d4c72a1e9ecb0107ecbd8