Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Hideo Nambu"'
Autor:
Takaaki Furihata, Satoshi Maekawa, Shingo Takada, Naoya Kakutani, Hideo Nambu, Ryosuke Shirakawa, Takashi Yokota, Shintaro Kinugawa
Publikováno v:
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be associated with a hi
Externí odkaz:
https://doaj.org/article/8b024ed27fa14a9cafdeeb5dc80db7df
Autor:
Naoya Kakutani, Shingo Takada, Hideo Nambu, Junichi Matsumoto, Takaaki Furihata, Takashi Yokota, Arata Fukushima, Shintaro Kinugawa
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-10 (2020)
Abstract Background Transforming growth factor beta (TGF-β)-Smad2/3 is the major signaling pathway of fibrosis, which is characterized by the excessive production and accumulation of extracellular matrix (ECM) components, including collagen. Althoug
Externí odkaz:
https://doaj.org/article/9f3ea013100c4153ba258f1957e6b740
Autor:
Satoshi Maekawa, Shingo Takada, Hideo Nambu, Takaaki Furihata, Naoya Kakutani, Daiki Setoyama, Yasushi Ueyanagi, Dongchon Kang, Hisataka Sabe, Shintaro Kinugawa
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-11 (2019)
Abstract Background Linoleic acid is the major fatty acid moiety of cardiolipin, which is central to the assembly of components involved in mitochondrial oxidative phosphorylation (OXPHOS). Although linoleic acid is an essential nutrient, its excess
Externí odkaz:
https://doaj.org/article/811987f1e75241fc8d0468896cd1625a
Autor:
Masaya Tsuda, Arata Fukushima, Junichi Matsumoto, Shingo Takada, Naoya Kakutani, Hideo Nambu, Katsuma Yamanashi, Takaaki Furihata, Takashi Yokota, Koichi Okita, Shintaro Kinugawa, Toshihisa Anzai
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 9, Iss 5, Pp 844-859 (2018)
Abstract Background Exercise intolerance is a common clinical feature and is linked to poor prognosis in patients with heart failure (HF). Skeletal muscle dysfunction, including impaired energy metabolism in the skeletal muscle, is suspected to play
Externí odkaz:
https://doaj.org/article/5be7a25d485d48ddbf56d267d0f98d0c
Autor:
Shingo Takada, Satoshi Maekawa, Takaaki Furihata, Naoya Kakutani, Daiki Setoyama, Koji Ueda, Hideo Nambu, Hikaru Hagiwara, Haruka Handa, Yoshizuki Fumoto, Soichiro Hata, Tomoka Masunaga, Arata Fukushima, Takashi Yokota, Dongchon Kang, Shintaro Kinugawa, Hisataka Sabe
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Heart failure (HF) is a leading cause of death and repeated hospitalizations and often involves cardiac mitochondrial dysfunction. However, the underlying mechanisms largely remain elusive. Here, using a mouse model in which myocardial infarction (MI
Autor:
Naoya Kakutani, Soichiro Hata, Satoshi Maekawa, Shingo Takada, Hideo Nambu, Yoshikuni Obata, Shintaro Kinugawa, Hikaru Hagiwara, Yoshizuki Fumoto, Takaaki Furihata, Arata Fukushima, Takashi Yokota, Ippei Nakano, Katsuma Yamanashi
Publikováno v:
Experimental Physiology. 106:1785-1793
NEW FINDINGS What is the central question of this study? We questioned whether an angiotensin-converting enzyme (ACE) inhibitor prevents skeletal muscle fibrosis in diabetic mice. What is the main finding and its importance? Administration of ACE inh
Autor:
Shingo Takada, Satoshi Maekawa, Takaaki Furihata, Naoya Kakutani, Daiki Setoyama, Koji Ueda, Hideo Nambu, Hikaru Hagiwara, Haruka Handa, Yoshizuki Fumoto, Soichiro Hata, Arata Fukushima, Takashi Yokota, Dongchon Kang, Shintaro Kinugawa, Hisataka Sabe
Heart failure (HF) is a leading cause of death and repeated hospitalizations1. HF progression generally involves mitochondrial dysfunction2-4. However, how mitochondria react to chronic HF remains unclear. Here, we show the molecular basis of mitocho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7c0770b8b535619de328ad949f75c38
https://doi.org/10.21203/rs.3.rs-838227/v1
https://doi.org/10.21203/rs.3.rs-838227/v1
Autor:
Masaya Tsuda, Junichi Matsumoto, Hisataka Sabe, Ryosuke Shirakawa, Toshihisa Anzai, Satoshi Maekawa, Takaaki Furihata, Kei Higashikawa, Hironobu Yasui, Ippei Nakano, Hideo Nambu, Takashi Yokota, Katsuma Yamanashi, Yoshikuni Obata, Shintaro Kinugawa, Akimichi Saito, Junko Nio-Kobayashi, Arata Fukushima, Takashi Katayama, Naoya Kakutani, Shingo Takada, Takayuki Nakajima, Yuji Kuge
Publikováno v:
Cardiovascular Research. 117:805-819
Aims Exercise intolerance in patients with heart failure (HF) is partly attributed to skeletal muscle abnormalities. We have shown that reactive oxygen species (ROS) play a crucial role in skeletal muscle abnormalities, but the pathogenic mechanism r
Autor:
Ryosuke Shirakawa, Shintaro Kinugawa, Takashi Yokota, Shingo Takada, Naoya Kakutani, Takaaki Furihata, Hideo Nambu, Satoshi Maekawa
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-10 (2021)
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-10 (2021)
Background Doxorubicin (DOX) is widely used as an effective chemotherapeutic agent for cancers; however, DOX induces cardiac toxicity, called DOX-induced cardiomyopathy. Although DOX-induced cardiomyopathy is known to be associated with a high cumula
Autor:
Takashi Yokota, Kota Ono, Hideo Nambu, Ryosuke Shirakawa, Koichi Okita, Toshihisa Anzai, Satoshi Maekawa, Takahiro Abe, Arata Fukushima, Takaaki Furihata, Shintaro Kinugawa, Takashi Katayama, Naoya Kakutani, Shingo Takada
Publikováno v:
Circulation Journal. 82:2753-2760
Background: Oxygen uptake (V̇O2) at peak workload and anaerobic threshold (AT) workload are often used for grading heart failure (HF) severity and predicting all-cause mortality. The clinical relevance of respiratory exchange ratio (RER) during exer