Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hideo Kiyonaga"'
Autor:
Hiroki Sato, Hideo Kiyonaga, Minoru Moriya, Yuichi Sugimoto, Shinnosuke Abe, Chinatsu Ikeura, Aya Shimizu, Terutaka Hashizume, Hideki Jona, Rie Nagano, Hideaki Imamura, Hajime Morishima, Norikazu Ohtake, Koji Yamada, Masato Nakano
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:1571-1578
A new class of 1 beta-methylcarbapenems bearing a doubly quaternarized 1,4-diazabicyclooctane (DABCO) substituted dithiocarbamate moiety at the C-2 side chain was prepared, and the biological profiles of the compounds, including in vitro and in vivo
Autor:
Aya Shimizu, Hideki Jona, Minoru Moriya, Hiroki Sato, Hideaki Imamura, Hideo Kiyonaga, Norikazu Ohtake, Masato Nakano, Ryosuke Ushijima, Nakagawa Susumu
Publikováno v:
Bioorganic & Medicinal Chemistry. 6:1089-1101
A new series of 1β-methyl carbapenems, in which a disubstituted-aminothiocarbonylthio moiety was attached to the C-2 position of the carbapenem nucleus, were prepared and evaluated for anti-MRSA activity. These derivatives showed good in vitro antib
Autor:
Aya Shimizu, Hiroki Sato, Masayuki Ogawa, Hideaki Imamura, Masato Nakano, Ryosuke Ushijima, Minoru Moriya, Hideki Jona, Yushin Tominaga, Hideo Kiyonaga, Koji Yamada, Susumu Nakagawa, Norikazu Ohtake, Shigemitsu Okada
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:1617-1622
A new series of carbapenems, in which disubstituted-aminothiocarbonylthio moiety, directly attached to the C-2 position, were prepared and evaluated for their antibacterial potency. These analogs showed potent activity against high-level MRSA. Among
Publikováno v:
Organic Preparations and Procedures International. 24:200-204
Publikováno v:
Chemical and Pharmaceutical Bulletin. 40:2654-2662
S-Alkyl dithiocarbonates (xanthates) of alkanols containing strained σ bonds underwent rearrangement to S, S-dialkyl dithiocarbonates, catalyzed by phenolic compounds. The reaction followed first-order kinetics and the rates were affected by the aci
Publikováno v:
Tetrahedron Letters. 32:7557-7558
The inclusion complex of O -cinnamyl S -methyl dithiocarbonate (xanthate) wtih β-cyclodextrin (β-CD) undergoes remarkably accelerated [3,3]-sigmatropic rearrangement to give the optically active dithiol ester in good yield with an enantiomeric exce
Publikováno v:
Chemical and Pharmaceutical Bulletin. 35:1388-1396
Ο- (1-Cyclopropylethyl) S-methyl dithiocarbonate (Ib) was solvolyzed in various solvents to give S- (1-cyclopropylethyl) S-methyl dithiocarbonate (IIb) quantitatively. The reaction obeyed the first-order rate law and the rates were considerably affe