Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Hideo HAKUSUI"'
Autor:
Tetsuo Satoh, Yoshinobu Yoshimura, Minezo Otsuka, Tsutomu Yoshimura, Hiroyuki Kobayashi, Akira Kagayama, Tomoyoshi Taniguchi, Eiji Aoyama, Toshiro Niwa, Satoshi Kobayashi, Masayoshi Yoshikawa, Shoji Kudo, Osamu Okazaki, Takehisa Hata, Satoshi Suzuki, Toshihiko Ikeda, Yasuhiro Yamada, Hideo Hakusui, Eiji Kashiyama, Kenji Nishimura, Gohachiro Miyamoto
Publikováno v:
Drug Metabolism and Pharmacokinetics. 16:115-126
Protocols for evaluating drug interaction caused by enzyme inhibition were established by the Drug Interaction Database Working Group of the Human and Animal Bridge Discussion Group (HAB). Basically, procedures for measurements of the inhibition cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48cf344263c84a5664b690a7501c7793
https://doi.org/10.2133/dmpk.16.115
https://doi.org/10.2133/dmpk.16.115
Autor:
Yoichi Murakami, Kenichi Sato, Hideo Hakusui, Kinuyo Kato, Makoto Tanaka, Yasushi Ito, Keiji Kawamoto
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:578-582
DZ-2640 is the ester-type oral carbapenem prodrug of an active parent compound, DU-6681. The pharmacokinetics and safety of DU-6681 were investigated in six studies after oral administration of a single dose of DZ-2640 to healthy male Japanese volunt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce560bb1856cc618072eeded515c012
https://doi.org/10.1128/aac.44.3.578-582.2000
https://doi.org/10.1128/aac.44.3.578-582.2000
Autor:
Hideo Hakusui
Publikováno v:
Drug Metabolism and Pharmacokinetics. 15:478-483
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4540915ace156f973b0b465745d5041f
https://doi.org/10.2133/dmpk.15.478
https://doi.org/10.2133/dmpk.15.478
Publikováno v:
Biochemical Pharmacology. 54:1225-1231
The effects of proton pump inhibitors on thyroid hormone metabolism in rats were examined. Pantoprazole, omeprazole, and lansoprazole were administered repeatedly to female SD rats at doses of 5, 50, and 300 mg/kg/day for 1 week, and changes in UDP-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abeb7fa19ae1cc1e77293686153b9efc
https://doi.org/10.1016/s0006-2952(97)00327-4
https://doi.org/10.1016/s0006-2952(97)00327-4
Publikováno v:
Drug Metabolism and Pharmacokinetics. 12:610-618
The absorption, distribution and excretion of ebselen were investigated after repeated oral administration of 14C-ebselen to male rats at a daily dose of 50 mg/kg for a maximum of 21 days. 1. The blood levels of radioactivity at 24 hr after dosing re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c55f9ffee0bac07ec16a0d1ec507fa6c
https://doi.org/10.2133/dmpk.12.610
https://doi.org/10.2133/dmpk.12.610
Autor:
Kouichi Hashimoto, Takako Honda, Matsuo Takaichi, Yoshio Esumi, Takashi Yokota, Hideo Hakusui, Hiroshi Masumoto
Publikováno v:
Drug Metabolism and Pharmacokinetics. 12:596-609
The absorption, distribution, metabolism and excretion of ebselen were investigated by single oral administration of radio-labelled 14C-ebselen to fasted male rats at a dose of 50 mg/kg. 1. The radioactivity in plasma reached the Cmax of 14.78 μg eq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d8434e1ea5f796acb091eaf37c7609e0
https://doi.org/10.2133/dmpk.12.596
https://doi.org/10.2133/dmpk.12.596
Autor:
Hideo Hakusui
Publikováno v:
Drug Metabolism and Pharmacokinetics. 12:225-228
Before the start of revise of the present PK guideline in Japan, PK study group of JPMA made inquiries about the present and the newly revised PK guideline (new PK guideline) of Japan to 96 numbers of companies in JPMA. Almost all companies (98.6%) h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd5566d450881de91be7a56a63a04db9
https://doi.org/10.2133/dmpk.12.225
https://doi.org/10.2133/dmpk.12.225
Publikováno v:
Chemical and Pharmaceutical Bulletin. 44:1425-1430
Quinolones are a group of potent antibacterial agents. Many reports show that oral absorption of quinolones is reduced by coadministration of metallic preparations. For better understanding of this phenomenon, we investigated the complex formations o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e9add37fb75b48ed477ee0f8ac0b251
https://doi.org/10.1248/cpb.44.1425
https://doi.org/10.1248/cpb.44.1425
Autor:
Hisashi Nomura, Matsuo Takaichi, Shinya Hanawa, Rikio Yanagida, Osamu Okazaki, Noriko Masubuchi, Hideo Hakusui
Publikováno v:
Drug Metabolism and Pharmacokinetics. 10:819-829
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::296b4ff33b09f82af6b450d4c07ebda4
https://doi.org/10.2133/dmpk.10.819
https://doi.org/10.2133/dmpk.10.819
Publikováno v:
Chemical and Pharmaceutical Bulletin. 43:649-653
Differential scanning calorimetry (DSC) curves of levofloxacin hemihydrate measured under various conditions showed different thermograms. These phenomena were attributed to be the dehydration. Dehydration caused a multiple-phase transition. Dehydrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a536bf6cbf90b8ff1a078ef8aaa3a077
https://doi.org/10.1248/cpb.43.649
https://doi.org/10.1248/cpb.43.649