Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Hideo Ema"'
Autor:
Zixian Liu, Jinhong Wang, Yao Ma, Miner Xie, Peng Wu, Sen Zhang, Xiaofang Wang, Fang Dong, Hui Cheng, Ping Zhu, Mingzhe Han, Hideo Ema
Publikováno v:
Blood Science, Vol 6, Iss 2, p e00187 (2024)
Hematopoietic stem cells (HSCs) have been considered to progressively lose their self-renewal and differentiation potentials prior to the commitment to each blood lineage. However, recent studies have suggested that megakaryocyte progenitors (MkPs) a
Externí odkaz:
https://doaj.org/article/9db7a7cadbb64a7f9126db0196e1ec01
Autor:
Bingqing Luo, Fang Dong, Tiejun Qin, Qingyun Zhang, Haitao Bai, Jinhong Wang, Yujiao Jia, Shihui Ma, Erlie Jiang, Tao Cheng, Zhijian Xiao, Hideo Ema
Publikováno v:
Experimental Hematology & Oncology, Vol 11, Iss 1, Pp 1-6 (2022)
Abstract Myelodysplastic syndromes (MDS) are generally considered as a group of clonal diseases derived from hematopoietic stem cells, but a number of studies have suggested that they are derived from myeloid progenitor cells. We aimed to identify th
Externí odkaz:
https://doaj.org/article/f3d4bf1ff80c48068dec9de28efd383f
Autor:
Shanshan Zhang, Aled O’Neill, Miner Xie, Peng Wu, Xiaofang Wang, Haitao Bai, Fang Dong, Jinhong Wang, Qingyun Zhang, Toshio Suda, Hideo Ema
Publikováno v:
Blood Science, Vol 3, Iss 4, Pp 113-121 (2021)
Abstract. Radioprotection was previously considered as a function of hematopoietic stem cells (HSCs). However, recent studies have reported its activity in hematopoietic progenitor cells (HPCs). To address this issue, we compared the radioprotection
Externí odkaz:
https://doaj.org/article/7be3dc66f3c54808acac3c617791f7f7
Autor:
Shanshan Zhang, Maiko Morita, Zhao Wang, Jun Ooehara, Sen Zhang, Miner Xie, Haitao Bai, Wenying Yu, Xiaofang Wang, Fang Dong, Jinhong Wang, Shihui Ma, Satoshi Yamazaki, Hideo Ema
Publikováno v:
Blood Science, Vol 1, Iss 1, Pp 92-101 (2019)
Abstract. Hematopoietic stem cells (HSCs) self-renew or differentiate through division. Cytokines are essential for inducing HSC division, but the optimal cytokine combination to control self-renewal of HSC in vitro remains unclear. In this study, we
Externí odkaz:
https://doaj.org/article/381d3d7b52e94d89b35bbae3995df44a
Autor:
Miner Xie, Shanshan Zhang, Fang Dong, Qingyun Zhang, Jinhong Wang, Chenchen Wang, Caiying Zhu, Sen Zhang, Bingqing Luo, Peng Wu, Hideo Ema
Publikováno v:
Haematologica, Vol 106, Iss 6 (2020)
Granulocyte colony-stimulating factor (G-CSF) is widely used in clinical settings to mobilize hematopoietic stem cells (HSCs) into the circulation for HSC harvesting and transplantation. However, whether G-CSF directly stimulates HSCs to change their
Externí odkaz:
https://doaj.org/article/c6d7667fab694109b76084c41eb01dd5
Autor:
Xiaofang Wang, Fang Dong, Sen Zhang, Wanzhu Yang, Wenying Yu, Zhao Wang, Shanshan Zhang, Jinhong Wang, Shihui Ma, Peng Wu, Yun Gao, Ji Dong, Fuchou Tang, Tao Cheng, Hideo Ema
Publikováno v:
Stem Cell Reports, Vol 11, Iss 1, Pp 274-287 (2018)
Summary: Transforming growth factor β1 (TGF-β1) plays a role in the maintenance of quiescent hematopoietic stem cells (HSCs) in vivo. We asked whether TGF-β1 controls the cell cycle status of HSCs in vitro to enhance the reconstitution activity. T
Externí odkaz:
https://doaj.org/article/3cc5174f123e4d9690c14ff53c7f25ac
Autor:
Hideo Ema
Publikováno v:
Blood Science, Vol 1, Iss 1, Pp 116-118 (2019)
Abstract. Ex vivo expansion of hematopoietic stem cells (HSCs) is considered the holy grail in stem cell biology and therapy, as it has long been difficult to make this procedure possible. Yamazaki's research team has established new, polyvinyl alcoh
Externí odkaz:
https://doaj.org/article/f025547262e545d89d165bb3377c5a2d
Autor:
Tianyuan Hu, Cong Li, Le Wang, Yingchi Zhang, Luyun Peng, Hui Cheng, Yajing Chu, Weili Wang, Hideo Ema, Yingdai Gao, Zhenyu Ju, Zhongzhou Yang, Xiaomin Wang, Tao Cheng, Weiping Yuan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a pivotal regulator in the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway that have been shown to play key roles in the functional development of B and T cells via activation of
Externí odkaz:
https://doaj.org/article/0c1327a89dcc4eef9b1ed592b725aa6d
Autor:
Aki Ieyasu, Reiko Ishida, Takaharu Kimura, Maiko Morita, Adam C. Wilkinson, Kazuhiro Sudo, Toshinobu Nishimura, Jun Ohehara, Yoko Tajima, Chen-Yi Lai, Makoto Otsu, Yukio Nakamura, Hideo Ema, Hiromitsu Nakauchi, Satoshi Yamazaki
Publikováno v:
Stem Cell Reports, Vol 8, Iss 3, Pp 500-508 (2017)
Hematopoietic stem cells (HSCs) are considered one of the most promising therapeutic targets for the treatment of various blood disorders. However, due to difficulties in establishing stable maintenance and expansion of HSCs in vitro, their insuffici
Externí odkaz:
https://doaj.org/article/47fe572a6dc64eb6ae4582546be94214
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-4 (2016)
Abstract Background Adult hematopoietic stem cells (HSCs), the ideal system for regenerative research, were isolated at single cell levels decades ago, whereas studies on embryonic HSCs are much more difficult. Methods Zhou et al identified a new pre
Externí odkaz:
https://doaj.org/article/6a2b6fe8ae624dceaf8c6c7f31ae942e