Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Hidenori Okamura"'
Publikováno v:
Molecules, Vol 28, Iss 4, p 1766 (2023)
Synthetic unnatural base pairs have been proven to be attractive tools for the development of DNA-based biotechnology. Our group has very recently reported on alkynylated purine–pyridazine pairs, which exhibit selective and stable base-pairing via
Externí odkaz:
https://doaj.org/article/e8138495f98d4e649aa9a5fb46e38520
Autor:
Sidney Becker, Christina Schneider, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Milan Dejmek, Thomas Carell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
How RNA building blocks have formed on an early Earth by a continuous process is still a mystery awaiting its solution. Here, the authors report that fluctuations of physical parameters like temperature and pH could have been enough to facilitate nuc
Externí odkaz:
https://doaj.org/article/f30b47cab3884e568cef79fb2ecc6324
Publikováno v:
Applied Sciences, Vol 10, Iss 21, p 7709 (2020)
Selective chemical reactions of biomolecules are some of the important tools for investigations by biological studies. We have developed the selective crosslinking reactions to form covalent bonds to DNA or RNA using crosslinking oligonucleotides (CF
Externí odkaz:
https://doaj.org/article/2d6dd9ef7e3c4475bcb8b363b61b32ce
Publikováno v:
Organic Letters. 25:466-470
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::155c783f813a12ca29fe603654d5cab4
https://doi.org/10.1021/acs.orglett.2c04015
https://doi.org/10.1021/acs.orglett.2c04015
In this paper, we describe a novel N–O photolysis of o-nitrobenzyl oxime ethers that enables the synthesis of phenanthridines via intramolecular cyclization reactions. Without the use of additional photocatalysts or photosensitizers, the process pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d99cc6cc215e9e7ad007acbb954be2bb
https://doi.org/10.26434/chemrxiv-2022-gjn1v
https://doi.org/10.26434/chemrxiv-2022-gjn1v
Autor:
Ahmed Mostafa, Abdelhady, Yu, Hirano, Kazumitsu, Onizuka, Hidenori, Okamura, Yasuo, Komatsu, Fumi, Nagatsugi
Publikováno v:
Current Protocols. 2
Crosslinking reactions to nucleic acids are an effective way to prepare stable complexes formed by covalent bonding. We demonstrated that fully 2'-O-methylated (2'-OMe) RNAs having a 2-amino-6-vinylpurine (AVP) exhibited an efficient crosslinking to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a58e6a9f259adb675098c9a70a53d2
https://doi.org/10.1002/cpz1.386
https://doi.org/10.1002/cpz1.386
Publikováno v:
Chemical Communications. 56:9731-9734
We recently found the translocation of double-stranded DNA into the nucleus. We herein describe the concept of novel booster oligodeoxynucleotides including 2'-deoxy uridine, which release antigene oligonucleotides in the nucleus by enzymatic digesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83efae1aab18df30705657f5c53ba70c
https://doi.org/10.1039/d0cc04240d
https://doi.org/10.1039/d0cc04240d
Autor:
Yosuke Taniguchi, Shigeki Sasaki, Ryotaro Notomi, Takayuki Osuki, Yuya Magata, Lei Wang, Hidenori Okamura
Publikováno v:
Organic & Biomolecular Chemistry. 18:2845-2851
Expansion of the triplex DNA forming sequence is required in the genomic targeting fields. Basically, triplex DNA is formed by the interaction between the triplex-forming oligonucleotides and homo-purine region with the target duplex DNA. The presenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105c47c12e6f1f89c38bdefa6a8c649c
https://doi.org/10.1039/d0ob00420k
https://doi.org/10.1039/d0ob00420k
Autor:
Hidenori Okamura, Giang Hoang Trinh, Zhuoxin Dong, Yoshiaki Masaki, Kohji Seio, Fumi Nagatsugi
Publikováno v:
Nucleic acids research. 50(6)
Unnatural base pairs (UBPs) which exhibit a selectivity against pairing with canonical nucleobases provide a powerful tool for the development of nucleic acid-based technologies. As an alternative strategy to the conventional UBP designs, which invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f61cf6f50efc84d35b28db4c6a5491
https://pubmed.ncbi.nlm.nih.gov/35234916
https://pubmed.ncbi.nlm.nih.gov/35234916
Autor:
David Jan Drexler, Samuele Stazzoni, Gregor Witte, Hidenori Okamura, Felix Müller, Alexander Pichler, Thomas Carell, Karl-Peter Hopfner, Clemens Reto Dialer, Simon Veth
Publikováno v:
Chemistry – A European Journal
2'3'-cGAMP is an uncanonical cyclic dinucleotide where one A and one G base are connected via a 3'-5' and a unique 2'-5' linkage. The molecule is produced by the cyclase cGAS in response to cytosolic DNA binding. cGAMP activates STING and hence one o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d460222f310744fa407e7cc3e5d3070
https://doi.org/10.1002/chem.201805409
https://doi.org/10.1002/chem.201805409