Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Hidenori Nonaka"'
Autor:
Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Masashi Toyoda, Tohru Kimura, Masahiko Kuroda, Atsuko Nakazawa, Mureo Kasahara, Hidenori Nonaka, Akihide Kamiya, Tohru Kiyono, Tohru Kobayshi, Yasufumi Murakami, Akihiro Umezawa
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-20 (2022)
Abstract Background The liver plays an important role in various metabolic processes, including protein synthesis, lipid and drug metabolisms and detoxifications. Primary culture of hepatocytes is used for the understanding of liver physiology as wel
Externí odkaz:
https://doaj.org/article/3b7afa866c0c4031afff482241b80dda
Autor:
Shoko Miyata, Noriaki Saku, Saeko Akiyama, Palaksha Kanive Javaregowda, Kenta Ite, Nagisa Takashima, Masashi Toyoda, Kei Yura, Tohru Kimura, Hiroshi Nishina, Atsuko Nakazawa, Mureo Kasahara, Hidenori Nonaka, Tohru Kiyono, Akihiro Umezawa
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2022)
Abstract Background Many drugs have the potential to induce the expression of drug-metabolizing enzymes, particularly cytochrome P450 3A4 (CYP3A4), in hepatocytes. Hepatocytes can be accurately evaluated for drug-mediated CYP3A4 induction; this is th
Externí odkaz:
https://doaj.org/article/53e970eb9c7b483b8c5026ed976e2f1c
Autor:
Ruri Tsuneishi, Noriaki Saku, Shoko Miyata, Saeko Akiyama, Palaksha Kanive Javaregowda, Kenta Ite, Nagisa Takashima, Masashi Toyoda, Tohru Kimura, Masahiko Kuroda, Atsuko Nakazawa, Mureo Kasahara, Hidenori Nonaka, Akihide Kamiya, Tohru Kiyono, Junji Yamauchi, Akihiro Umezawa
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Ammonia has a cytotoxic effect and can therefore be used as a selection agent for enrichment of zone I hepatocytes. However, it has not yet been determined whether ammonia-treated hepatocyte-like cells are able to proliferate in vitro. In th
Externí odkaz:
https://doaj.org/article/4f38116df54040ec862438c4cefb639a
Autor:
André Scholich, Simon Syga, Hernán Morales-Navarrete, Fabián Segovia-Miranda, Hidenori Nonaka, Kirstin Meyer, Walter de Back, Lutz Brusch, Yannis Kalaidzidis, Marino Zerial, Frank Jülicher, Benjamin M Friedrich
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009349 (2021)
[This corrects the article DOI: 10.1371/journal.pcbi.1008412.].
Externí odkaz:
https://doaj.org/article/562e92c4e98747b8bd823ffd68969ef9
Autor:
André Scholich, Simon Syga, Hernán Morales-Navarrete, Fabián Segovia-Miranda, Hidenori Nonaka, Kirstin Meyer, Walter de Back, Lutz Brusch, Yannis Kalaidzidis, Marino Zerial, Frank Jülicher, Benjamin M Friedrich
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008412 (2020)
How epithelial cells coordinate their polarity to form functional tissues is an open question in cell biology. Here, we characterize a unique type of polarity found in liver tissue, nematic cell polarity, which is different from vectorial cell polari
Externí odkaz:
https://doaj.org/article/a411acdfd1eb43caad3cd203f6095013
Autor:
Hernán Morales-Navarrete, Hidenori Nonaka, André Scholich, Fabián Segovia-Miranda, Walter de Back, Kirstin Meyer, Roman L Bogorad, Victor Koteliansky, Lutz Brusch, Yannis Kalaidzidis, Frank Jülicher, Benjamin M Friedrich, Marino Zerial
Publikováno v:
eLife, Vol 8 (2019)
Functional tissue architecture originates by self-assembly of distinct cell types, following tissue-specific rules of cell-cell interactions. In the liver, a structural model of the lobule was pioneered by Elias in 1949. This model, however, is in co
Externí odkaz:
https://doaj.org/article/33e29e9f287b4b73becdf7cfdc1d6f67
Autor:
Hernán Morales-Navarrete, Fabián Segovia-Miranda, Piotr Klukowski, Kirstin Meyer, Hidenori Nonaka, Giovanni Marsico, Mikhail Chernykh, Alexander Kalaidzidis, Marino Zerial, Yannis Kalaidzidis
Publikováno v:
eLife, Vol 4 (2015)
A prerequisite for the systems biology analysis of tissues is an accurate digital three-dimensional reconstruction of tissue structure based on images of markers covering multiple scales. Here, we designed a flexible pipeline for the multi-scale reco
Externí odkaz:
https://doaj.org/article/e44f77d36a6143a99d278551a9d47ccd
Autor:
Roberto Villaseñor, Hidenori Nonaka, Perla Del Conte-Zerial, Yannis Kalaidzidis, Marino Zerial
Publikováno v:
eLife, Vol 4 (2015)
An outstanding question is how receptor tyrosine kinases (RTKs) determine different cell-fate decisions despite sharing the same signalling cascades. Here, we uncovered an unexpected mechanism of RTK trafficking in this process. By quantitative high-
Externí odkaz:
https://doaj.org/article/3b2f53c4f64b46b781d3bebd42a746f4
Autor:
Saeko Akiyama, Noriaki Saku, Shoko Miyata, Kenta Ite, Hidenori Nonaka, Masashi Toyoda, Akihide Kamiya, Tohru Kiyono, Tohru Kimura, Mureo Kasahara, Akihiro Umezawa
As a metabolic organ, the liver plays a variety of roles, including detoxification. It has been difficult to obtain stable supplies of hepatocytes for transplantation and for accurate hepatotoxicity determination in drug discovery research. Human plu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31ef24a6e9a8d990b5b7a95ab38f3c76
https://doi.org/10.1101/2023.02.21.529337
https://doi.org/10.1101/2023.02.21.529337
Autor:
Fabián Segovia-Miranda, Hernán Morales-Navarrete, Frank Jülicher, Marino Zerial, Yannis Kalaidzidis, Benjamin M. Friedrich, Walter de Back, Kirstin Meyer, André Scholich, Simon Syga, Lutz Brusch, Hidenori Nonaka
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 8, p e1009349 (2021)
[This corrects the article DOI: 10.1371/journal.pcbi.1008412.].
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d229e7bc8851116b05f7ebf8babbe7d8
https://doaj.org/article/562e92c4e98747b8bd823ffd68969ef9
https://doaj.org/article/562e92c4e98747b8bd823ffd68969ef9